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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
August 2005 Volume 16 Issue 2

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Article

Anti-viral activity of human antithrombin III

David R. Elmaleh, Nancy V. Brown, Ralf Geiben-Lynn
Pages: 191-200
Published online on: 01 August 2005

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Review

Rational role of amino acids in intestinal epithelial cells (Review)

Yoshio Naomoto, Tomoki Yamatsuji, Kaori Shigemitsu, Hidetoshi Ban, Tohru Nakajo, Yasuhiro Shirakawa, Takayuki Motok, Masahiko Kobayashi, Mehmet Gunduz, Noriaki Tanaka
Pages: 201-204
Published online on: 01 August 2005

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Article

Cloning of the nucleostemin gene and its function in transforming human embryonic bone marrow mesenchymal stem cells into F6 tumor cells

Chongxu Han, Xiran Zhang, Wenrong Xu, Wenbing Wang, Hui Qian, Yongchang Chen
Pages: 205-213
Published online on: 01 August 2005

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Article

P-glycoprotein expression influences the result of 99mTc-MIBI scintigraphy in tertiary hyperparathyroidism

Witold Chudzinski, Justyna Niderla, Zofia Lasiecka, Grzegorz Wilczynski, Barbara Gornicka, Aleksander Wasiutynski, Joanna Maczewska, Malgorzata Kobylecka, Leszek Krolicki, Magdalena Durlik, Ewa Nowacka, Maciej Lazarczyk, Piotr Dziunycz, Lukasz Milewski, Ireneusz Nawrot, Tomasz Grzela
Pages: 215-219
Published online on: 01 August 2005

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Article

Gene expression profiling predicts liver responses to a herbal remedy after partial hepatectomy in mice

Jir-You Wang, Jen-Hwey Chiu, Tung-Hu Tsai, Ann-Ping Tsou, Cheng-Po Hu, Chin-Wen Chi, Shou-Fan Yeh, Wing-Yiu Lui, Chew-Wun Wu, Chen-Kung Chou
Pages: 221-231
Published online on: 01 August 2005

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Article

Glycyrrhizin induces apoptosis in human stomach cancer KATO III and human promyelotic leukemia HL-60 cells

Hiroshige Hibasami, Hiroshi Iwase, Kazumi Yoshioka, Hidehisa Takahashi
Pages: 233-236
Published online on: 01 August 2005

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Article

SIRT1 is critical regulator of FOXO-mediated transcription in response to oxidative stress

Yosuke Kobayashi, Yoko Furukawa-Hibi, Chen Chen, Yoshiyuki Horio, Kenichi Isobe, Kyoji Ikeda, Noboru Motoyama
Pages: 237-243
Published online on: 01 August 2005

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Article

Preparation of anti-orotate phosphoribosyltransferase antibody and its application to immunochemical detection in human tumor cells

Kazuki Sakamoto, Yoshikazu Sugimoto, Kazutaka Miyadera, Toshinori Oka, Masakazu Fukushima
Pages: 245-249
Published online on: 01 August 2005

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Article

Novel interaction between nuclear co-activator CBP and the CDK5 activator binding protein - C53

Xiaolong Yin, Dennis R. Warner, Emily A. Roberts, M. Michele Pisano, Robert M. Greene
Pages: 251-256
Published online on: 01 August 2005

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Article

Phosphorylation of p27(KIP1) in the developing retina and retinoblastoma

Satoru Kase, Kazuhiko Yoshida, Keiichi I. Nakayama, Keiko Nakayama, Hiromi Ikeda, Takayuki Harada, Chikako Harada, Kazuhiro Ohgami, Kenji Shiratori, Shigeaki Ohno
Pages: 257-262
Published online on: 01 August 2005

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Article

Expression of SPARC in tongue carcinoma of stage II is associated with poor prognosis: An immunohistochemical study of 86 cases

Yasumasa Kato, Yoji Nagashima, Yuh Baba, Toshiro Kawano, Madoka Furukawa, Akira Kubota, Shunsuke Yanoma, Yukari Imagawa-Ishiguro, Kenichi Satake, Takahide Taguchi, Ryu-Ichiro Hata, Izumi Mochimatsu, Ichiro Aoki, Yoichi Kameda, Yoshiaki Inayama, Mamoru Tsukuda
Pages: 263-268
Published online on: 01 August 2005

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Article

Galectin-9 as a regulator of cellular adhesion in human oral squamous cell carcinoma cell lines

Atsushi Kasamatsu, Katsuhiro Uzawa, Dai Nakashima, Hirofumi Koike, Masashi Shiiba, Hiroki Bukawa, Hidetaka Yokoe, Hideki Tanzawa
Pages: 269-273
Published online on: 01 August 2005

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Review

Safety of quercetin for clinical application (Review)

Toshihiro Okamoto
Pages: 275-278
Published online on: 01 August 2005

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Article

Long-term follow-up of Japanese patients with chronic hepatitis B treated with interferon-α

Bui Xuan Truong, Yasushi Seo, Miyuki Kato, Kenichi Hamano, Toshiaki Ninomiya, Megumi Katayama, Hirotaka Kato, Yoshihiko Yano, Yoshitake Hayashi, Masato Kasuga
Pages: 279-284
Published online on: 01 August 2005

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Article

Effect of high hydrostatic pressure on biological properties of extracellular bone matrix proteins

Peter Diehl, Manfred Schmitt, Johannes Schauwecker, Kay Eichelberg, Hans Gollwitzer, Reiner Gradinger, Michael Goebel, Klaus T. Preissner, Wolfram Mittelmeier, Ursula Magdolen
Pages: 285-289
Published online on: 01 August 2005

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Article

Extrahepatic manifestations and insulin resistance in an HCV hyperendemic area

Yumiko Nagao, Takumi Kawaguchi, Kazuo Tanaka, Ryukichi Kumashiro, Michio Sata
Pages: 291-296
Published online on: 01 August 2005

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Article

Effects of beacon on the rat pituitary-adrenocortical axis response to stress

Marcin Rucinski, Raffaella Spinazzi, Agnieszka Ziolkowska, Gastone G. Nussdorfer, Ludwik K. Malendowicz
Pages: 297-299
Published online on: 01 August 2005

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Article

A comparison between in vivo and ex vivo HR-MAS 1H MR spectra of a pediatric posterior fossa lesion

V. Tugnoli, L. Schenetti, A. Mucci, L. Nocetti, C. Toraci, L. Mavilla, G. Basso, R. Rovati, F. Tavani, E. Zunarelli, V. Righi, M.R. Tosi
Pages: 301-307
Published online on: 01 August 2005

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Article

Prognostic predictors in breast cancer patients with postoperative 5-fluorouracil-based chemotherapy

Yasuhiko Hakamada, Akihiko Tsuchida, Masaaki Arima, Takeo Kubouchi, Hiromi Tokita, Daisuke Ota, Hiroshi Kaise, Toshiaki Aoki, Mikihiro Kusama, Tatsuya Aoki
Pages: 309-314
Published online on: 01 August 2005

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Article

Effects of volatile constituents of a rosemary extract on allergic airway inflammation related to house dust mite allergen in mice

Ken-Ichiro Inoue, Hirohisa Takano, Akira Shiga, Yoji Fujita, Hiroaki Makino, Rie Yanagisawa, Takamichi Ichinose, Yoji Kato, Tomozo Yamada, Toshikazu Yoshikawa
Pages: 315-319
Published online on: 01 August 2005

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Article

The influence of ATP on poly(ADP-ribose) metabolism

Pal I. Bauer, Erzsebet Kenesi, Jerome Mendeleyev, Ernest Kun
Pages: 321-324
Published online on: 01 August 2005

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Article

A very short segment of the murine Ret promoter contains elements sensitive to in vitro neural cell differentiation

Paola Zordan, Roberto Ravazzolo, Renata Bocciardi
Pages: 325-331
Published online on: 01 August 2005

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Article

In vitro inhibition of R5 HIV-1 infectivity by X4 V3-derived synthetic peptides

Stavroula Baritaki, Matthias T. Dittmar, Demetrios A. Spandidos, Elias Krambovitis
Pages: 333-336
Published online on: 01 August 2005

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Article

Activities of fresh juice of Scutellaria barbata and warmed water extract of Radix Sophorae Tonkinensis on anti-proliferation and apoptosis of human cancer cell lines

Chung Hin Chui, Fung Yi Lau, Johnny Cheuk On Tang, Kin Luen Kan, Gregory Yin Ming Cheng, Raymond Siu Ming Wong, Stanton Hon Lung Kok, Paul Bo San Lai, Rocky Ho, Roberto Gambari, Albert Sun Chi Chan
Pages: 337-341
Published online on: 01 August 2005

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Article

Identification and characterization of ankyrin repeat and SOCS box-containing gene ASB15 in silico

Kenichi Yoshida
Pages: 343-347
Published online on: 01 August 2005

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Article

Expression levels of the EZH2 polycomb transcriptional repressor correlate with aggressiveness and invasive potential of bladder carcinomas

Steffen Weikert, Frank Christoph, Jens Köllermann, Markus Müller, Mark Schrader, Kurt Miller, Hans Krause
Pages: 349-353
Published online on: 01 August 2005

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Article

Comparative genomics on mammalian Fgf6-Fgf23 locus

Yuriko Katoh, Masaru Katoh
Pages: 355-358
Published online on: 01 August 2005

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Journal Cover
June-2026 Volume 57 Issue 6

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Article

Gilteritinib overcomes second‑generation TKIs resistance in ALK‑rearranged non‑small‑cell lung cancer by inhibiting PD‑L1 and CD8 co‑expression

Hang Guo, Yaoji Li, Chengyan Jin, Xiao Qi, Jincheng Wang, Baofeng Li, Chunguang Wang
Article Number: 168
Published online on: 28 April 2026

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Retraction Open Access

[Retracted] Metformin‑induced activation of AMPK inhibits the proliferation and migration of human aortic smooth muscle cells through upregulation of p53 and IFI16

Biao Hao, Yan Xiao, Fang Song, Xiangshu Long, Jing Huang, Maobo Tian, Shiyan Deng, Qiang Wu
Article Number: 167
Published online on: 22 April 2026

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Review Open Access

Dysregulation of the DNA repair‑immune axis: Targeted therapeutic strategies for autoimmune diseases (Review)

Ke Wan, Miao Wang, Qingqing Xia, Hui Fang, Ying Chen, Tongsheng Zhou, Xue Yang, Lu Wang, Jianwen Ye, Han Shu, Xiao-Feng Li, Jun Li
Article Number: 166
Published online on: 22 April 2026

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Retraction Open Access

[Retracted] Puerarin attenuates glucocorticoid‑induced apoptosis of hFOB1.19 cells through the JNK‑ and Akt‑mediated mitochondrial apoptotic pathways

Dongdong Yu, Shuai Mu, Danyang Zhao, Guangbin Wang, Zhiguang Chen, Hongfei Ren, Qin Fu
Article Number: 165
Published online on: 20 April 2026

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Review Open Access

High‑altitude polycythemia: Unveiling the molecular landscape beyond erythropoietin (Review)

Haiyan Li, Hongjuan Zhang, Hujun Zhang, Yujie Li, Yigang He, Jia Luan
Article Number: 164
Published online on: 17 April 2026

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Review

Mechanistic roles of interleukin‑18 in colonic immunity across infection, inflammatory bowel disease, and colorectal cancer (Review)

Jingwen Zhang, Lili Bao, Xia Li, Jiaxi Li, Jiaxian Cui, Lu Qiao, Xiaoxia He, Mingyu Zhang, Jingkun Lu, Xuan Zhang, Jing Dong, Gesi Tao, Tuya Bai, Yun Peng Tian, Pengwei Zhao, Ya Tuo
Article Number: 163
Published online on: 17 April 2026

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Article Open Access

IDH2 lactylation regulates mitochondrial dysfunction injury induced by myocardial ischemia‑reperfusion via the AMPK signaling pathway

Changsen Wang, Siman Shen, Suyun Chen, Jinda Lin, Simeng Li, Jianning Chen, Shuyun Cai, Xiaodong Yuan, Ziqiang Yang, Kun Ding, Li Xu, Liangqing Zhang
Article Number: 162
Published online on: 17 April 2026

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Review Open Access

Context‑dependent duality of the apelin/elabela‑APJ system in diabetes and its complications (Review)

Zhenyuan Han, Jiale Zhang, Min Shi, Juan Chen, Anni Li, Yuxuan Ye, Hong Zhang
Article Number: 161
Published online on: 17 April 2026

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Review Open Access

Glycolytic lactylation modulates cell death decisions in diabetic kidney disease: Metabolic‑epigenetic interplay between ferroptosis and autophagy in fibrotic remodeling (Review)

Taimin Zhang, Xizhe Zhang, Yaru Xie, Yue Liu, Siyu Xia, Xiaodie Yin, Tian Li, Libin Liao
Article Number: 160
Published online on: 16 April 2026

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Retraction Open Access

[Retracted] Quercetin promotes the apoptosis of fibroblast‑like synoviocytes in rheumatoid arthritis by upregulating lncRNA MALAT1

Fang Pan, Lihua Zhu, Haozhe Lv, Chunpeng Pei
Article Number: 159
Published online on: 15 April 2026

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Article Open Access

Triptolide exerts antiviral effects and alleviates influenza A‑induced pneumonia by inhibiting the overactivation of absent in melanoma 2 signaling in immune cells

Yeyang Chen, Hua Wu, Xiangjian Wu, Likun Che, Xiaoyan Fu, Ruihan Qi, Dan Jia, Minfang Li, Wei Xie, Wenxiang Zhu
Article Number: 158
Published online on: 15 April 2026

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Review Open Access

ETS‑1/ETS‑2 transcription factors in CVD (Review)

Shasha Yang, Jing Zhang, Ying Yang, Yunbo Lv, Jian Yang, Huibo Wang
Article Number: 157
Published online on: 15 April 2026

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Review Open Access

RNA‑binding proteins as epithelial transcriptome orchestrators in gastric cancer: Immune‑metabolic crosstalk and therapeutic vulnerability (Review)

Shuhui Liu, Zhiyuan Ma, Bei Ji, Jiaxing Zhu, Shun Yao, Shuji Terai, Biguang Tuo, Taolang Li, Xuemei Liu
Article Number: 156
Published online on: 14 April 2026

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Retraction Open Access

[Retracted] Role of miR‑146a in human chondrocyte apoptosis in response to mechanical pressure injury in vitro  

Lei Jin, Jian Zhao, Wensen Jing, Shiju Yan, Xin Wang, Chun Xiao, Baoan Ma
Article Number: 155
Published online on: 07 April 2026

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Review Open Access

A tale of dual role: HECT‑type E3 ubiquitin ligase mechanisms in liver diseases (Review)

Tongxi Li, Hao Chen, Peng Zhao, Chuanzheng Yin, Zifang Song
Article Number: 154
Published online on: 07 April 2026

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Correction Open Access

[Corrigendum] Macrophage‑derived foam cells impair endothelial barrier function by inducing endothelial‑mesenchymal transition via CCL‑4 

Ying Yang, Nian-Sang Luo, Ru Ying, Yong Xie, Jia-Yuan Chen, Xiao-Qiao Wang, Zhen-Jie Gu, Jing-Ting Mai, Wen-Hao Liu, Mao-Xiong Wu, Zhi-Teng Chen, Yong-Biao Fang, Hai-Feng Zhang, Zhi-Yi Zuo, Jing-Feng Wang, Yang-Xin Chen
Article Number: 153
Published online on: 03 April 2026

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Review Open Access

Macrophage metabolism reprogramming in sepsis: Pathogenesis and therapeutic implications (Review)

Tong Zhao, Wenzhe Zhang, Zixuan Ren, Xiujing Feng
Article Number: 152
Published online on: 03 April 2026

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Article Open Access

Astragaloside IV targets TUBB4B to inhibit proliferation and promote apoptosis of pituitary tumor cells via the STMN1/ERK pathway

Jiale Li, Yufei Qu, Wenge Zhang, Zexu Yang, Yangdong Zeng, Jisheng Xu, Kuncen Xie, Qi Liu
Article Number: 151
Published online on: 01 April 2026

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Expression of Concern Open Access

[Expression of Concern] Increased expression of heat shock protein 90 under chemical hypoxic conditions protects cardiomyocytes against injury induced by serum and glucose deprivation

Keng Wu, Wenming Xu, Qiong You, Runmin Guo, Jianqiang Feng, Changran Zhang, Wen Wu
Article Number: 150
Published online on: 01 April 2026

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Review Open Access

Animal models accurately representing acute liver failure (Review)

Sang Luo, Fang Wu, Yiran Jin, Xiaofen Huang, Dan Liu, Bingren Tian
Article Number: 149
Published online on: 01 April 2026

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Correction Open Access

[Corrigendum] Influence of aspirin on the CX3CL1/CX3CR1 signaling pathway in acute pulmonary embolism 

Zhirong Zhang, Weiji Yang, Rongbiao Ying, Ying Shi, Huifang Jiang, Danli Cai, Jing Kuang, Ruhui Yang, Lingcong Wang
Article Number: 148
Published online on: 31 March 2026

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Review Open Access

Targeting pyroptosis to treat aortic aneurysms: From mechanism to drug discovery (Review)

Jing Mao, Mandi Luo, Lei Ruan, Cuntai Zhang
Article Number: 147
Published online on: 31 March 2026

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Review Open Access

Role of aging‑related cytokines in neurodegenerative disease (Review)

Xinke Dai, Xinran Rao, Yuandi Wang, Weijiang Zhao
Article Number: 146
Published online on: 31 March 2026

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Expression of Concern Open Access

[Expression of Concern] DTX3L is upregulated in glioma and is associated with glioma progression

Peng Xu, Xuelei Tao, Chengjin Zhao, Qingfeng Huang, Hao Chang, Na Ban, Yuanqi Bei, Xiaojie Xia, Chaoyan Shen, Kun Wang, Li Xu, Peizhang Wu, Jianbing Ren, Donglin Wang
Article Number: 145
Published online on: 30 March 2026

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Review Open Access

Role of itaconate in intestinal disease (Review)

Xin Li, Qian Liu, Jiajia Li, Li Zhang, Shun Yao, Lulu Tang, Bingqi Yang, Yongfeng Wang, Guorong Wen, Jiaxing An, Hai Jin, Biguang Tuo
Article Number: 144
Published online on: 27 March 2026

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Review Open Access

Unveiling lactylation: A novel frontier in the pathogenesis of diabetic nephropathy (Review)

Yuanyuan Xiao, Niansong Wang, Dingkun Gui, Youhua Xu
Article Number: 143
Published online on: 27 March 2026

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Review Open Access

Crosstalk between autophagy and ferroptosis in liver diseases (Review)

Yanming Wei, Kun Zhou, Yuerui Su, Zhihua Luan, Pengcheng Li, Yinxia Chang, Bo Han, Huifang Li, Yuanbiao Qiao, Jinhong Ren
Article Number: 142
Published online on: 26 March 2026

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Article Open Access

circOMA1 delivered by exosomes regulates DRD2‑mediated prolactinoma resistance

Qing Rao, Dimin Zhu, Zongming Wang, Shaolin Zhang, Xueli Li, Shashikiran Tagilapalli, Nan Wang, Weiyu Hu, Wenli Chen, Yonghong Zhu
Article Number: 141
Published online on: 26 March 2026

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Expression of Concern Open Access

[Expression of Concern] Involvement of Cyr61 in the growth, invasiveness and adhesion of esophageal squamous cell carcinoma cells

Jian-Jun Xie, Li-Yan Xu, Yang-Min Xie, Ze-Peng Du, Cai-Hua Feng, Hui Dong, En-Min Li
Article Number: 140
Published online on: 24 March 2026

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Article Open Access

Novel Hsp90 inhibitor JD‑02 inhibits HSV‑1 infection via the Raf/MEK/ERK signaling pathway

Yexuan Zhu, Xiaohui Wang, Jiaying Lin, Xiao Wang, Kai Zheng, Zhe Ren, Ji Xiao, Yifei Wang
Article Number: 139
Published online on: 24 March 2026

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Journal Cover
July-2026 Volume 58 Issue 1

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Article Open Access

Dapagliflozin attenuates ferroptosis in diabetic nephropathy through activation of the Nrf2/HO‑1 signaling pathway

Hanshuang Liu, Xiaoxiao Zhang, Yubing Cui, Shengxi Xiong, Linjuan Huang, Min Li, Chen Shao, Xiaolei Hu
Article Number: 171
Published online on: 30 April 2026

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Article Open Access

Ligustroflavone protects against acute kidney injury by inhibiting ferroptosis via acting on GSK3β/NRF2 signaling

Jiayu Song, Long Wang, Yaru Wang, Jie Meng, Jingyi Sheng, Yongfeng Zhao, San Yan Xu, Juan Lei, Fangfang Cai, Yunwen Yang
Article Number: 170
Published online on: 30 April 2026

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Correction Open Access

[Corrigendum] Differential regulation of the biosynthesis of glucose transporters by the PI3‑K and MAPK pathways of insulin signaling by treatment with novel compounds from Liriope platyphylla

Yoen Kyung Lee, Ji Eun Kim, So Hee Nam, Jun Seo Goo, Sun Il Cho, Young Hwan Choi, Chang Jun Bae, Ong Min Woo, Jung Sik Cho, Dae Youn Hwang
Article Number: 169
Published online on: 28 April 2026

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