Mucin expression and proliferating cell index of esophageal Barrett's adenocarcinoma

  • Authors:
    • Soichiro Yamamoto
    • Hiroshi Kijima
    • Tadashi Hara
    • Osamu Chino
    • Hideo Shimada
    • Makiko Tanaka
    • Sadaki Inokuchi
    • Hiroyasu Makuuchi
  • View Affiliations

  • Published online on: September 1, 2005     https://doi.org/10.3892/ijmm.16.3.375
  • Pages: 375-380
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Abstract

Barrett's esophagus is a premalignant condition associated with gastroesophageal reflux disease, and consists of mucosa with a metaplastic columnar epithelium (specialized columnar epithelium). In this study, we examined the expression of mucin and the Ki-67 labeling index (LI) in 15 cases of esophageal Barrett's adenocarcinoma, and clarified the significance of incomplete intestinal metaplasia of Barrett's mucosa as a premalignant lesion. Gastric mucin (MUC5AC, HGM, and/or MUC6) was detected in 93.3% of the adenocarcinomas, while MUC2 and CD10 (markers of intestinal phenotypes) were detected in 73.3% and 46.2%, respectively. The Ki-67 LI was 34.1% in Barrett's adenocarcinoma. In all cases, gastric mucin was found in the non-neoplastic Barrett's mucosa around the adenocarcinoma. MUC2 was detected in 86.7% of proximal non-neoplastic mucosa and 100% of distal non-neoplastic mucosa, while CD10 was found in 20.0% of proximal non-neoplastic mucosa and 40.0% of distal non-neoplastic mucosa of Barrett's adenocarcinoma. In conclusion, Barrett's esophageal mucosa with intestinal metaplasia and a high Ki-67 LI is suggested to be more important as a premalignant lesion, and predominantly found in the proximal rather than distal region of Barrett's esophagus.

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September 2005
Volume 16 Issue 3

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Yamamoto S, Kijima H, Hara T, Chino O, Shimada H, Tanaka M, Inokuchi S and Makuuchi H: Mucin expression and proliferating cell index of esophageal Barrett's adenocarcinoma. Int J Mol Med 16: 375-380, 2005
APA
Yamamoto, S., Kijima, H., Hara, T., Chino, O., Shimada, H., Tanaka, M. ... Makuuchi, H. (2005). Mucin expression and proliferating cell index of esophageal Barrett's adenocarcinoma. International Journal of Molecular Medicine, 16, 375-380. https://doi.org/10.3892/ijmm.16.3.375
MLA
Yamamoto, S., Kijima, H., Hara, T., Chino, O., Shimada, H., Tanaka, M., Inokuchi, S., Makuuchi, H."Mucin expression and proliferating cell index of esophageal Barrett's adenocarcinoma". International Journal of Molecular Medicine 16.3 (2005): 375-380.
Chicago
Yamamoto, S., Kijima, H., Hara, T., Chino, O., Shimada, H., Tanaka, M., Inokuchi, S., Makuuchi, H."Mucin expression and proliferating cell index of esophageal Barrett's adenocarcinoma". International Journal of Molecular Medicine 16, no. 3 (2005): 375-380. https://doi.org/10.3892/ijmm.16.3.375