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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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September 2005 Volume 16 Issue 3

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

An International Open Access Journal Devoted to General Medicine.

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September 2005 Volume 16 Issue 3

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Article

Comparison of cytotoxicity induced by hypolipidemic drugs via reactive oxygen species in human and rodent liver cells

  • Authors:
    • Philippe Becuwe
    • Michel Dauça

  • View Affiliations / Copyright

    Affiliations: Laboratoire de Biologie Cellulaire du Développement, EA 3446 ‘Proliférateurs de Peroxysomes,’ Université Henri Poincaré-Nancy I, Faculté des Sciences, B.P. 239, 54506 Vandoeuvre-lés-Nancy, France. becuwe@scbiol.u-nancy.fr
  • Pages: 483-492
    |
    Published online on: September 1, 2005
       https://doi.org/10.3892/ijmm.16.3.483
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Abstract

Hypolipidemic drugs (HP drugs) are xenobiotics belonging to the peroxisome proliferator family which are used as pharmaceuticals in the treatment of human hyperlipidemia and hypercholesterolemia. They cause hepatocarcinogenesis in rodents by increasing cell proliferation. One hypothesis is that this hepatocarcinogenic effect is caused by induced oxidative stress resulting from the overproduction of reactive oxygen species (ROS) and from a decreasing antioxidant defense. In addition, ROS play a role in hepatocellular proliferation by activation of NF-κB and AP-1, leading to an increase in mitogenic cytokines such as tumor necrosis factor-alpha. No liver cancer incidence has been noted in individuals treated with HP drugs for brief periods of time. However, the observation that old rats and mice are more susceptible than young individuals to the hepatocarcinogenic effect caused by long term exposure to HP drugs raises the question of a potential health risk for the human population. In vitro, HP drugs cause an apoptogenic effect in human hepatocytes. This effect is related to a moderate antioxidant response, dysfunction of mitochondria caused by an overproduction of ROS and release of apoptogenic factors. Finally, the apoptogenic effect of HP drugs is observed in human hepatomas, suggesting a clinical interest of these agents in antitumoral activity.

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Copy and paste a formatted citation
Spandidos Publications style
Becuwe P and Dauça M: Comparison of cytotoxicity induced by hypolipidemic drugs via reactive oxygen species in human and rodent liver cells. Int J Mol Med 16: 483-492, 2005.
APA
Becuwe, P., & Dauça, M. (2005). Comparison of cytotoxicity induced by hypolipidemic drugs via reactive oxygen species in human and rodent liver cells. International Journal of Molecular Medicine, 16, 483-492. https://doi.org/10.3892/ijmm.16.3.483
MLA
Becuwe, P., Dauça, M."Comparison of cytotoxicity induced by hypolipidemic drugs via reactive oxygen species in human and rodent liver cells". International Journal of Molecular Medicine 16.3 (2005): 483-492.
Chicago
Becuwe, P., Dauça, M."Comparison of cytotoxicity induced by hypolipidemic drugs via reactive oxygen species in human and rodent liver cells". International Journal of Molecular Medicine 16, no. 3 (2005): 483-492. https://doi.org/10.3892/ijmm.16.3.483
Copy and paste a formatted citation
x
Spandidos Publications style
Becuwe P and Dauça M: Comparison of cytotoxicity induced by hypolipidemic drugs via reactive oxygen species in human and rodent liver cells. Int J Mol Med 16: 483-492, 2005.
APA
Becuwe, P., & Dauça, M. (2005). Comparison of cytotoxicity induced by hypolipidemic drugs via reactive oxygen species in human and rodent liver cells. International Journal of Molecular Medicine, 16, 483-492. https://doi.org/10.3892/ijmm.16.3.483
MLA
Becuwe, P., Dauça, M."Comparison of cytotoxicity induced by hypolipidemic drugs via reactive oxygen species in human and rodent liver cells". International Journal of Molecular Medicine 16.3 (2005): 483-492.
Chicago
Becuwe, P., Dauça, M."Comparison of cytotoxicity induced by hypolipidemic drugs via reactive oxygen species in human and rodent liver cells". International Journal of Molecular Medicine 16, no. 3 (2005): 483-492. https://doi.org/10.3892/ijmm.16.3.483
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