Decreased expression of interleukin-21 receptor on peripheral B lymphocytes in systemic lupus erythematosus

  • Authors:
    • Hiroki Mitoma
    • Takahiko Horiuchi
    • Yasutaka Kimoto
    • Hiroshi Tsukamoto
    • Ayumi Uchino
    • Yasuhiro Tamimoto
    • Yugo Miyagi
    • Mine Harada
  • View Affiliations

  • Published online on: October 1, 2005     https://doi.org/10.3892/ijmm.16.4.609
  • Pages: 609-615
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Abstract

Interleukin-21 (IL-21) is the most recent member of the common γ-chain-dependent cytokine family. We studied the expression of the IL-21 receptor (IL-21R) on peripheral B lymphocytes in patients with systemic lupus erythematosus (SLE) or primary Sjögren's syndrome (pSjS), and healthy controls. Naive B lymphocytes expressed higher levels of IL-21R than memory B lymphocytes and plasmablasts, both in SLE patients and healthy controls. The proportion of IL-21R+ cells in the total peripheral B lymphocytes, as well as those in the respective B lymphocyte subsets, was significantly lower in SLE compared with those of pSjS or healthy controls (p=0.0002 and p<0.0001, respectively, in total B lymphocytes). The decreased expression of IL-21R in SLE was significantly associated with nephritis and high titer anti-double-strand DNA antibody. In some SLE patients, IL-21-induced proliferation of CD19+ B lymphocytes, in the presence of CD40 stimulation, was impaired. The abnormalities of IL-21R signaling might contribute to the pathological features of SLE, such as B lymphocytopenia.

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October 2005
Volume 16 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Mitoma H, Horiuchi T, Kimoto Y, Tsukamoto H, Uchino A, Tamimoto Y, Miyagi Y and Harada M: Decreased expression of interleukin-21 receptor on peripheral B lymphocytes in systemic lupus erythematosus. Int J Mol Med 16: 609-615, 2005.
APA
Mitoma, H., Horiuchi, T., Kimoto, Y., Tsukamoto, H., Uchino, A., Tamimoto, Y. ... Harada, M. (2005). Decreased expression of interleukin-21 receptor on peripheral B lymphocytes in systemic lupus erythematosus. International Journal of Molecular Medicine, 16, 609-615. https://doi.org/10.3892/ijmm.16.4.609
MLA
Mitoma, H., Horiuchi, T., Kimoto, Y., Tsukamoto, H., Uchino, A., Tamimoto, Y., Miyagi, Y., Harada, M."Decreased expression of interleukin-21 receptor on peripheral B lymphocytes in systemic lupus erythematosus". International Journal of Molecular Medicine 16.4 (2005): 609-615.
Chicago
Mitoma, H., Horiuchi, T., Kimoto, Y., Tsukamoto, H., Uchino, A., Tamimoto, Y., Miyagi, Y., Harada, M."Decreased expression of interleukin-21 receptor on peripheral B lymphocytes in systemic lupus erythematosus". International Journal of Molecular Medicine 16, no. 4 (2005): 609-615. https://doi.org/10.3892/ijmm.16.4.609