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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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November 2005 Volume 16 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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November 2005 Volume 16 Issue 5

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Article

Inhibition of proteasome activity in Gleditsia sinensis fruit extract-mediated apoptosis on human carcinoma cells

  • Authors:
    • Filly Cheung
    • Chung Hin Chui
    • Albert Sun Chi Chan
    • Fung Yi Lau
    • Gregory Yin Ming Cheng
    • Raymond Siu Ming Wong
    • Stanton Hon Lung Kok
    • Ivy Tuang Ngo Teo
    • Chor Hing Cheng
    • Johnny Cheuk On Tang

  • View Affiliations / Copyright

    Affiliations: State Key Laboratory of Chinese Medicine and Molecular Pharmacology, Shenzhen, P.R. China
  • Pages: 925-929
    |
    Published online on: November 1, 2005
       https://doi.org/10.3892/ijmm.16.5.925
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Abstract

The anomalous fruit extract of Gleditsia sinensis (GSE) was shown to possess anticancer potential on various solid tumour and leukaemia cell lines in vitro. We have recently demonstrated that the mitochondrial-dependent apoptotic pathway including mitochondrial membrane potential depolarization, changes in the level of reactive oxygen species and activation of caspase 3 were recruited in GSE-induced apoptosis. Whether receptor-dependent APO-1/Fas apoptotic pathway is also involved remains uncertain. Using two solid tumour cell lines, the HepG2 hepatoblastoma carcinoma cells and MDA-MB231 breast cancer cells, we demonstrated that the Fas ligand and Fas receptor protein levels did not have significant variation after GSE incubation. Caspase 8 activity increased only weakly when compared with that of caspase 3. The chrymotrypsin-like activity of proteasome was partially inhibited up to 30-40% when compared with the untreated control. Taken together, we believe that GSE- mediated apoptosis on HepG2 and MDA-MB231 carcinoma cells is mainly dictated by the mitochondrial-dependent pathway while inhibition of proteasome activity may also be involved in GSE-induced apoptosis.

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Copy and paste a formatted citation
Spandidos Publications style
Cheung F, Chui CH, Chan AS, Lau FY, Cheng GY, Wong RS, Kok SH, Teo IT, Cheng CH, Tang JC, Tang JC, et al: Inhibition of proteasome activity in Gleditsia sinensis fruit extract-mediated apoptosis on human carcinoma cells. Int J Mol Med 16: 925-929, 2005.
APA
Cheung, F., Chui, C.H., Chan, A.S., Lau, F.Y., Cheng, G.Y., Wong, R.S. ... Tang, J.C. (2005). Inhibition of proteasome activity in Gleditsia sinensis fruit extract-mediated apoptosis on human carcinoma cells. International Journal of Molecular Medicine, 16, 925-929. https://doi.org/10.3892/ijmm.16.5.925
MLA
Cheung, F., Chui, C. H., Chan, A. S., Lau, F. Y., Cheng, G. Y., Wong, R. S., Kok, S. H., Teo, I. T., Cheng, C. H., Tang, J. C."Inhibition of proteasome activity in Gleditsia sinensis fruit extract-mediated apoptosis on human carcinoma cells". International Journal of Molecular Medicine 16.5 (2005): 925-929.
Chicago
Cheung, F., Chui, C. H., Chan, A. S., Lau, F. Y., Cheng, G. Y., Wong, R. S., Kok, S. H., Teo, I. T., Cheng, C. H., Tang, J. C."Inhibition of proteasome activity in Gleditsia sinensis fruit extract-mediated apoptosis on human carcinoma cells". International Journal of Molecular Medicine 16, no. 5 (2005): 925-929. https://doi.org/10.3892/ijmm.16.5.925
Copy and paste a formatted citation
x
Spandidos Publications style
Cheung F, Chui CH, Chan AS, Lau FY, Cheng GY, Wong RS, Kok SH, Teo IT, Cheng CH, Tang JC, Tang JC, et al: Inhibition of proteasome activity in Gleditsia sinensis fruit extract-mediated apoptosis on human carcinoma cells. Int J Mol Med 16: 925-929, 2005.
APA
Cheung, F., Chui, C.H., Chan, A.S., Lau, F.Y., Cheng, G.Y., Wong, R.S. ... Tang, J.C. (2005). Inhibition of proteasome activity in Gleditsia sinensis fruit extract-mediated apoptosis on human carcinoma cells. International Journal of Molecular Medicine, 16, 925-929. https://doi.org/10.3892/ijmm.16.5.925
MLA
Cheung, F., Chui, C. H., Chan, A. S., Lau, F. Y., Cheng, G. Y., Wong, R. S., Kok, S. H., Teo, I. T., Cheng, C. H., Tang, J. C."Inhibition of proteasome activity in Gleditsia sinensis fruit extract-mediated apoptosis on human carcinoma cells". International Journal of Molecular Medicine 16.5 (2005): 925-929.
Chicago
Cheung, F., Chui, C. H., Chan, A. S., Lau, F. Y., Cheng, G. Y., Wong, R. S., Kok, S. H., Teo, I. T., Cheng, C. H., Tang, J. C."Inhibition of proteasome activity in Gleditsia sinensis fruit extract-mediated apoptosis on human carcinoma cells". International Journal of Molecular Medicine 16, no. 5 (2005): 925-929. https://doi.org/10.3892/ijmm.16.5.925
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