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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
November 2005 Volume 16 Issue 5

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Article

Blockage of the ERK signaling pathway abrogates the SCAP ligand-induced transcriptional activation of the LDL receptor gene in HepG2 cells

Parveen Abidi, Fang Zhang, Cong Li, Jingwen Liu
Pages: 779-785
Published online on: 01 November 2005

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Article

G protein-coupled APJ receptor signaling induces focal adhesion formation and cell motility

Yasumi Hashimoto, Junji Ishida, Rie Yamamoto, Kae Fujiwara, Sachie Asada, Yoshitoshi Kasuya, Naoki Mochizuki, Akiyoshi Fukamizu
Pages: 787-792
Published online on: 01 November 2005

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Article

The exploration of joint-specific immunoreactions on immunoglobulins G of anti-glucose-6-phosphate isomerase antibody-positive patients with rheumatoid arthritis

Isao Matsumoto, Yoshifumi Muraki, Takanori Yasukochi, Zhang Hua, Yuko Kori, Taichi Hayashi, Daisuke Goto, Satoshi Ito, Akito Tsutsumi, Kotaro Ikeda, Hiroshi Sumichika, Takayuki Sumida
Pages: 793-800
Published online on: 01 November 2005

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Article

Soluble amyloid β-peptide and myelin basic protein strongly stimulate, alone and in synergism with combined proinflammatory cytokines, the expression of functional nitric oxide synthase-2 in normal adult human astrocytes

Anna Chiarini, Ilaria Dal Pra, Lia Menapace, Raffaella Pacchiana, James F. Whitfield, Ubaldo Armato
Pages: 801-807
Published online on: 01 November 2005

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Article

Nuclear localization of a novel protein, RGPR-p117, in cloned normal rat kidney proximal tubular epithelial cells

Natsumi Sawada, Taeko Nakagawa, Tomiyasu Murata, Masayoshi Yamaguchi
Pages: 809-814
Published online on: 01 November 2005

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Article

Detection of HPV 52, 58 and 87 in cervicovaginal intraepithelial lesions of HIV infected women

Susanne Haas, Tjoung-Won Park, Esther Voigt, Reinhard Büttner, Sabine Merkelbach-Bruse
Pages: 815-819
Published online on: 01 November 2005

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Article

Transfecting the multidrug resistance protein 2 gene improves transcellular organic anion transport

Toshio Itani, Yoshinao Kobayashi, Makoto Kuroda, Ning Ma, Rumi Mifuji, Naohito Urawa, Yuji Tanaka, Masahiko Kaito, Yukihiko Adachi
Pages: 821-825
Published online on: 01 November 2005

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Article

A novel single-nucleotide substitution, Glu 4 Lys, in the leukotriene C4 synthase gene associated with allergic diseases

Kaori Yoshikawa, Eiko Matsui, Hideo Kaneko, Toshiyuki Fukao, Ryosuke Inoue, Takahide Teramoto, Shinji Shinoda, Osamu Fukutomi, Minako Aoki, Kimiko Kasahara, Naomi Kondo
Pages: 827-831
Published online on: 01 November 2005

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Article

Induction of heat shock protein 72 in C6 glioma cells by methyl jasmonate through ROS-dependent heat shock factor 1 activation

Su Young Oh, Ji Hye Kim, Min Jung Park, Sun Mi Kim, Chang Shin Yoon, Young Mi Joo, Jang Su Park, Song Iy Han, Hye Gyeong Park, Ho Sung Kang
Pages: 833-839
Published online on: 01 November 2005

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Implication of reactive oxygen species, ERK1/2, and p38MAPK in sodium salicylate-induced heat shock protein 72 expression in C6 glioma cells

Myoung Suk Seo, Su Young Oh, Min Jung Park, Sun Mi Kim, Min Young Kim, Song Iy Han, Hye Gyeong Park, Ho Sung Kang
Pages: 841-849
Published online on: 01 November 2005

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Article

Identification of novel mutations of IRF6 gene in Chinese families with Van der Woude syndrome

Xiao-Qian Ye, Hui-Xi Jin, Li-Song Shi, Ming-Wen Fan, Guang-Tai Song, Hua-Li Fan, Zhuan Bian
Pages: 851-856
Published online on: 01 November 2005

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Article

Quantitative detection of telomerase activity by real-time TRAP assay in the body fluids of cancer patients

Woo Young Shim, Kyu Hyun Park, Hei-Chul Jeung, Yong Tae Kim, Tae Soo Kim, Woo Jin Hyung, Sung Hwan An, Sang Hwa Yang, Sung Hoon Noh, Hyun Cheol Chung, Sun Young Rha
Pages: 857-863
Published online on: 01 November 2005

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Article

Expression of Y-Box binding protein-1 following hypericin-mediated photodynamic therapy in well-differentiated nasopharyngeal cancer in vivo

Hong-Yan Du, Malini Olivo, Ying-Jie Chen, George Yip, Puay-Hoon Tan, Ken Matsumoto, Masafumi Tsujimoto, Boon-Huat Bay
Pages: 865-868
Published online on: 01 November 2005

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Article

Tumor necrosis factor alpha promotes an osteoblast-like phenotype in human aortic valve myofibroblasts: A potential regulatory mechanism of valvular calcification

Jens J. Kaden, Refika Kiliç, Aslihan Sarikoç, Siegfried Hagl, Siegfried Lang, Ursula Hoffmann, Martina Brueckmann, Martin Borggrefe
Pages: 869-872
Published online on: 01 November 2005

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Article

Role of protein kinase C in expression of granulocyte-colony stimulating factor and granulocyte macrophage-colony stimulating factor in lung cancer cells

Yoshiki Uemura, Makoto Kobayashi, Hideshi Nakata, Tetsuya Kubota, Tsuyako Saito, Kentaro Bandobashi, Hirokuni Taguchi
Pages: 873-881
Published online on: 01 November 2005

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Article

Marked telomere fluctuation of leukocytes during graft-versus-host disease in allogeneic stem cell transplantation

Goro Sashida, Junko H. Ohyashiki, Naoshi Kubota, Nahoko Shoji, Yuko Ishii, Tetsuzo Tauchi, Yukihiko Kimura, Jerry W. Shay, Kazuma Ohyashiki
Pages: 883-888
Published online on: 01 November 2005

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Article

Differential-expression and tyrosine-phosphorylation profiles of caveolin isoforms in human T cell leukemia cell lines

Yuichiro Tsuji, Michiyo Hatanaka, Tamaki Maeda, Tsukasa Seya, Hiroshi Takenaka, Akira Shimizu
Pages: 889-893
Published online on: 01 November 2005

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Article

Synthesis and evaluation of trimethoxyphenyl isoxazolidines as inhibitors of secretory phospholipase A2 with anti-inflammatory activity

M. P. Sadashiva, A. Nataraju, H. Mallesha, R. Rajesh, B. S. Vishwanath, K. S. Rangappa
Pages: 895-904
Published online on: 01 November 2005

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Article

LASS6, an additional member of the longevity assurance gene family

Arndt Weinmann, Peter R. Galle, Andreas Teufel
Pages: 905-910
Published online on: 01 November 2005

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Maintenance of open DNA base pairs through histone acetylated lysine-purine interaction leading to transcriptional activation: A proposed mechanism

Solon Georghiou, Anas M. Ababneh
Pages: 911-917
Published online on: 01 November 2005

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Phylogeny of the TMEM16 protein family: Some members are overexpressed in cancer

Blanca E. Galindo, Victor D. Vacquier
Pages: 919-924
Published online on: 01 November 2005

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Article

Inhibition of proteasome activity in Gleditsia sinensis fruit extract-mediated apoptosis on human carcinoma cells

Filly Cheung, Chung Hin Chui, Albert Sun Chi Chan, Fung Yi Lau, Gregory Yin Ming Cheng, Raymond Siu Ming Wong, Stanton Hon Lung Kok, Ivy Tuang Ngo Teo, Chor Hing Cheng, Johnny Cheuk On Tang
Pages: 925-929
Published online on: 01 November 2005

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Article

Antiproliferation and induction of cell death of Phaffia rhodozyma (Xanthophyllomyces dendrorhous) extract fermented by brewer malt waste on breast cancer cells

Ivy Tuang Ngo Teo, Chung Hin Chui, Johnny Cheuk On Tang, Fung Yi Lau, Gregory Yin Ming Cheng, Raymond Siu Ming Wong, Stanton Hon Lung Kok, Chor Hing Cheng, Albert Sun Chi Chan, Kwok Ping Ho
Pages: 931-936
Published online on: 01 November 2005

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Article

Regulation of tyrosine phosphorylation during the CD40-mediated rescue of Ramos-BL B cells from BCR-triggered apoptosis

Kroum K. Hristov, Kirstine A. Knox, Vanio I. Mitev
Pages: 937-941
Published online on: 01 November 2005

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Article

UV-induced NF-κB activation and expression of IL-6 is attenuated by (-)-epigallocatechin-3-gallate in cultured human keratinocytes in vitro

Jiping Xia, Xiuzu Song, Zhigang Bi, Wenming Chu, Yinsheng Wan
Pages: 943-950
Published online on: 01 November 2005

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Article

The order of PNA-FISH-detected chromosomal telomere lengths in human T-cells is rather stable, even under the influence of strong mutagens

U. Wick, E. Gebhart
Pages: 951-957
Published online on: 01 November 2005

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Article

Comparative genomics on FGF16 orthologs

Yuriko Katoh, Masaru Katoh
Pages: 959-963
Published online on: 01 November 2005

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Journal Cover
January-2026 Volume 57 Issue 1

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

FK506‑binding proteins as emerging bridges linking proteostasis to multi‑system pathogenesis and therapeutic strategies (Review)

Zhi Li, Xiaolei Liu, Hesong Zeng
Article Number: 30
Published online on: 24 November 2025

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Retraction Open Access

[Retracted] Suppression of SIK1 by miR‑141 in human ovarian cancer cell lines and tissues

Jin-Long Chen, Fang Chen, Ting-Ting Zhang, Nai-Fu Liu
Article Number: 29
Published online on: 24 November 2025

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Article Open Access

METTL3 inhibits LINC00312 to suppress osteoporosis progression in a YTHDF2‑dependent manner

Yang Wang, Yihao Tian, Gang Yao
Article Number: 28
Published online on: 20 November 2025

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Decoding structural birth defects through genomic landscapes: Innovative frameworks for diagnosis (Review)

Ruihao Xu, Haoming Ren, Zhengwei Yuan, Wanqi Huang, Hui Gu
Article Number: 27
Published online on: 20 November 2025

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MOTS‑c protects against placental injury via Nrf2 activation in hypoxia‑induced intrauterine growth restriction mice

Dan Chen, Hui-Min Zhao, Xiao-Lin Sun, Zhi-Xuan Xing, Sheng-Peng Li, Shuai-Chao Li, Ya-Xian Wu, Qing-Feng Pang, Jian-Feng Huang
Article Number: 26
Published online on: 18 November 2025

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Synergistic effects of Akebia saponin D and Semaglutide on diabetic nephropathy and osteoporosis via the Klotho‑p53 signaling axis

Qian Zhang, Dan Wang, Hongxia Jia, Zongji Zheng, Liyan Lin, Linna Li, Ling Wang, Yaoming Xue
Article Number: 25
Published online on: 18 November 2025

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Retraction Open Access

[Retracted] MicroRNA‑103 modulates tumor progression by targeting KLF7 in non‑small cell lung cancer

Ke Li, Conghu Yuan
Article Number: 24
Published online on: 17 November 2025

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Article

Comparative analysis of pan MHC‑I epitopes immunoreactivity on Hantaan virus nucleocapsid protein

Zhikui Li, Weijie Ding, Yubo Sun, Chenfeng Tian, Shuaishuai Fu, Fei Shi, Zhenchi Fang, Yuanzhe Li, Jianchang Li, Sirui Cai, Haobo Kang, Baozeng Sun, Junqi Zhang, Yuanjie Sun, Shuya Yang, Yusi Zhang, Chunmei Zhang, Yun Zhang, Xiyang Zhang, Kun Yang, Dongbo Jiang
Article Number: 23
Published online on: 14 November 2025

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Article Open Access

Human papillomavirus E7 inhibits immune responses in keratinocytes by activating HTRA1‑mediated mitophagy

Boya Zhang, Defeng Kong, Siji Chen, Xuewu Sun, Hao Cheng
Article Number: 22
Published online on: 14 November 2025

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Article Open Access

Targeting p38 MAPK signaling pathway: 
Quercetin as a novel therapy for TMJ synovitis

Mosha Cheng, Yuhe Guan, Xiaotao Xin, Xin Yi, Yi Liu
Article Number: 21
Published online on: 13 November 2025

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Lipid droplets in astrocytes: Key organelles for CNS homeostasis and disease (Review)

Yuchen Wang, Boxuan Wang, Jinchao Hou, Xiaodong Huo, Chenlin Liu, Ruili Guan, Honggang Chen, Yang Zhou, Jianbin Zhang, Congcong Zhuang, Yuankang Zou
Article Number: 20
Published online on: 13 November 2025

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Copper dyshomeostasis and cardiovascular disease: Molecular mechanisms and new strategies for targeted intervention with cuproptosis (Review)

Peiyu Li, Yinghui Li, Qian Meng, Jie Wang, Kun Wang, Sumin Yang
Article Number: 19
Published online on: 13 November 2025

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Elevated FTO alleviates sepsis‑induced acute kidney injury by regulating macrophage inflammatory phenotypes

Xiaona Chen, Ziqi Sun, Jiabo Chen, Jinquan Zhang, Zeyu Liu, Zhengzheng Yan, Quan Li, Zhixia Chen
Article Number: 18
Published online on: 12 November 2025

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Correction Open Access

[Corrigendum]  Suppression of PAX6 promotes cell proliferation and inhibits apoptosis in human retinoblastoma cells

Bo Meng, Yisong Wang, Bin Li
Article Number: 17
Published online on: 10 November 2025

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Microbial short chain fatty acids: Effective histone deacetylase inhibitors in immune regulation (Review)

Jing Wang, Qin Zhao, Shuwan Zhang, Jia Liu, Xingyue Fan, Bin Han, Yaqin Hou, Xiaopeng Ai
Article Number: 16
Published online on: 05 November 2025

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High‑fat diet and cognitive dysfunction: Mechanistic insights into diet‑induced neurodegeneration (Review)

Min You, Fan Wu, Feng Xiong, Xue-Fei Hu, Huan Wu, Li Zhou, Hong-Xing Zhang
Article Number: 15
Published online on: 05 November 2025

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ROCK inhibition promotes axon and myelin regeneration via PI3K/Akt/GSK3β in a mouse sciatic nerve injury model

Shuang Dou, Zhijun Li, Boyao Zheng, Zhenyu Ren, Hai Wang, Qing Zuo, Fang Fang, Yuehong Zhuang
Article Number: 14
Published online on: 05 November 2025

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Mechanisms of mTORC1 and GCN2 amino acid sensing pathways in tumorigenesis and metastatic progression (Review)

Chaowei Zhang, Yuxuan Han, Weiyi Yao, Qing Hong, Na Chen
Article Number: 13
Published online on: 04 November 2025

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β‑hydroxybutyric acid as a potential therapeutic metabolite for type 2 diabetes mellitus (Review)

Xianyi Ding, Jiabin Wu, Lian Wang, Ke Li, Haoyang Gao, Mingyu Wu, Qiuyu Zhang, Ruonan Han, Wenhong Wang, Weihua Xiao
Article Number: 12
Published online on: 03 November 2025

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Review

Histone lactylation: Unveiling a novel pathway for the impact of lactate on physiological and pathological processes (Review)

Xunjie Jian, Chang Cheng, Wenjie Lu, Hui Peng, Diqi Yang
Article Number: 11
Published online on: 03 November 2025

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Review Open Access

Interpretation of the molecular mechanism and therapeutic potential of microRNA‑155 in cardiovascular and cerebrovascular diseases (Review)

Xitong Zhao, Pengqin Wang
Article Number: 10
Published online on: 03 November 2025

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Expression of Concern Open Access

[Expression of Concern]  CDKN2A (p16INK4A) affects the anti‑tumor effect of CDK inhibitor in somatotroph adenomas

Yiyuan Chen, Zhenye Li, Qiuyue Fang, Hongyun Wang, Chuzhong Li, Hua Gao, Yazhuo Zhang
Article Number: 9
Published online on: 29 October 2025

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TWEAK modulates the characteristics of periodontal ligament stem cells via the Fn14/NF‑κB pathway

Linlin Xiao, Man Qu, Lulu Chen, Mingli Xiang, Qian Long, Jianguo Liu, Xiaoyan Guan, Chengcheng Liao
Article Number: 8
Published online on: 27 October 2025

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Review Open Access

Harnessing copper: Innovative approaches to combat neurodegenerative diseases and cancer (Review)

Tao Duan, Hanhai Mao, Xingyue Jiang, Ying Tian, Jidong Zhang, Jun Tan
Article Number: 7
Published online on: 27 October 2025

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Retraction Open Access

[Retracted] Effects of miR‑106b‑3p on cell proliferation and epithelial‑mesenchymal transition, and targeting of ZNRF3 in esophageal squamous cell carcinoma

Guanen Qiao, Chenguang Dai, Yang He, Junjie Shi, Chunfang Xu
Article Number: 6
Published online on: 27 October 2025

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Immune and metabolic remodeling following bariatric surgery: Implications for targeted immunotherapy (Review)

Yiming Shao, Ke Song, Ruixin Yu, He Xiao, Chengjun Li, Yuling Deng, Yuan Zhang, Yixing Ren
Article Number: 5
Published online on: 24 October 2025

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Exportin 1 inhibitor KPT‑330 reverses oxaliplatin resistance via p53 nuclear retention in colorectal cancer

Chuanxi Lai, Xiya Jia, Yiyi Chen, Kangke Chen, Fei Wang, Qiqi Zhang, Xiaonan Xiang, Zhe-Sheng Chen, Lingna Xu, Sheng Dai
Article Number: 4
Published online on: 23 October 2025

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Targeting of CIRP attenuates osteoarthritis progression via suppressing TLR4/NF‑κB/NLRP3 signaling axis

Weichao Sun, Yi Liao, Jianguo Feng, Jianhui Liang, Qifei He, Yinxing Cui, Dixi Huang, Houyin Shi, Wei You, Wei Sun, Qian Yi
Article Number: 3
Published online on: 23 October 2025

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Review

Importance of B cells (Review)

Zhiyuan Liu, Haoran Dai, Xiaoyu Cui, Yeping Liu, Zhaocheng Dong
Article Number: 2
Published online on: 22 October 2025

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Retraction Open Access

[Retracted] Hypoxic preconditioned bone mesenchymal stem cells ameliorate spinal cord injury in rats via improved survival and migration

Weiheng Wang, Xiaodong Huang, Wenbo Lin, Yuanyuan Qiu, Yunfei He, Jiangming Yu, Yanhai Xi, Xiaojian Ye
Article Number: 1
Published online on: 22 October 2025

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Journal Cover
February-2026 Volume 57 Issue 2

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Article Open Access

FGF4 alleviates the lung cell damage caused by high glucose via AMPK‑PGC‑1 signaling axis in vitro and in vivo

Qiujuan Fu, Yongfang Ou, Qin Wu, Jue Gong, Feixia Li, Tuxing Wang, Zhitai Lin, Kejie Huang, Jianlong Xie
Article Number: 39
Published online on: 05 December 2025

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FBXO22 promotes hepatocellular carcinoma progression via paracrine myo‑inositol‑induced M2‑type polarization of macrophages

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Article Number: 32
Published online on: 01 December 2025

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[Retracted] miR‑381 functions as a tumor suppressor by targeting ETS1 in pancreatic cancer

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Published online on: 01 December 2025

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