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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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December 2005 Volume 16 Issue 6

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

An International Open Access Journal Devoted to General Medicine.

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December 2005 Volume 16 Issue 6

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Article

Diosgenin, a plant steroid, induces apoptosis in COX-2 deficient K562 cells with activation of the p38 MAP kinase signalling and inhibition of NF-κB binding

  • Authors:
    • Bertrand Liagre
    • Julian Bertrand
    • David Y. Leger
    • Jean-Louis Beneytout

  • View Affiliations / Copyright

    Affiliations: Laboratoire de Biochimie, UPRES EA 1085, Faculté de Pharmacie, 87025 Limoges Cedex, France. bertrand.liagre@unilim.fr
  • Pages: 1095-1101
    |
    Published online on: December 1, 2005
       https://doi.org/10.3892/ijmm.16.6.1095
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Abstract

Diosgenin is a steroidal sapogenin with antitumor properties. We previously showed that diosgenin induced apoptosis in human erythroleukemia (HEL) cells. In order to elucidate the mechanism of its apoptotic activity, we investigated the effect of diosgenin on nuclear factor-κB (NF-κB) binding and on three groups of human mitogen-activated protein kinases (MAPKs) in relation to diosgenin-induced apoptosis in different erythroleukemia cell lines (K562 and HEL). Our results showed that diosgenin decreased DNA binding of NF-κB in K562 and HEL cells after 48-h diosgenin treatment. This inhibition of NF-κB binding was correlated with strong apoptosis in both erythroleukemia cell lines. Diosgenin-induced apoptosis was associated with cyclo-oxygenase-2 (COX-2) up-regulation in HEL cells but not in K562 cells which are COX-2 deficient. Furthermore, diosgenin inhibited extracellular signal-regulated kinase (ERK) activation only in HEL cells. However, diosgenin activated p38 MAPK in both cell lines and activated c-jun NH2-terminal kinases (JNKs) only in HEL cells. Pre-treatment with a selective p38 inhibitor inhibited diosgenin-induced DNA fragmentation in K562 cells. For the first time, our results suggest that inhibition of NF-κB nuclear binding and p38 MAPK activation are involved in the diosgenin-mediated signal cascades in K562 cells for inducing/regulating DNA fragmentation.

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Copy and paste a formatted citation
Spandidos Publications style
Liagre B, Bertrand J, Leger DY and Beneytout J: Diosgenin, a plant steroid, induces apoptosis in COX-2 deficient K562 cells with activation of the p38 MAP kinase signalling and inhibition of NF-κB binding. Int J Mol Med 16: 1095-1101, 2005.
APA
Liagre, B., Bertrand, J., Leger, D.Y., & Beneytout, J. (2005). Diosgenin, a plant steroid, induces apoptosis in COX-2 deficient K562 cells with activation of the p38 MAP kinase signalling and inhibition of NF-κB binding. International Journal of Molecular Medicine, 16, 1095-1101. https://doi.org/10.3892/ijmm.16.6.1095
MLA
Liagre, B., Bertrand, J., Leger, D. Y., Beneytout, J."Diosgenin, a plant steroid, induces apoptosis in COX-2 deficient K562 cells with activation of the p38 MAP kinase signalling and inhibition of NF-κB binding". International Journal of Molecular Medicine 16.6 (2005): 1095-1101.
Chicago
Liagre, B., Bertrand, J., Leger, D. Y., Beneytout, J."Diosgenin, a plant steroid, induces apoptosis in COX-2 deficient K562 cells with activation of the p38 MAP kinase signalling and inhibition of NF-κB binding". International Journal of Molecular Medicine 16, no. 6 (2005): 1095-1101. https://doi.org/10.3892/ijmm.16.6.1095
Copy and paste a formatted citation
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Spandidos Publications style
Liagre B, Bertrand J, Leger DY and Beneytout J: Diosgenin, a plant steroid, induces apoptosis in COX-2 deficient K562 cells with activation of the p38 MAP kinase signalling and inhibition of NF-κB binding. Int J Mol Med 16: 1095-1101, 2005.
APA
Liagre, B., Bertrand, J., Leger, D.Y., & Beneytout, J. (2005). Diosgenin, a plant steroid, induces apoptosis in COX-2 deficient K562 cells with activation of the p38 MAP kinase signalling and inhibition of NF-κB binding. International Journal of Molecular Medicine, 16, 1095-1101. https://doi.org/10.3892/ijmm.16.6.1095
MLA
Liagre, B., Bertrand, J., Leger, D. Y., Beneytout, J."Diosgenin, a plant steroid, induces apoptosis in COX-2 deficient K562 cells with activation of the p38 MAP kinase signalling and inhibition of NF-κB binding". International Journal of Molecular Medicine 16.6 (2005): 1095-1101.
Chicago
Liagre, B., Bertrand, J., Leger, D. Y., Beneytout, J."Diosgenin, a plant steroid, induces apoptosis in COX-2 deficient K562 cells with activation of the p38 MAP kinase signalling and inhibition of NF-κB binding". International Journal of Molecular Medicine 16, no. 6 (2005): 1095-1101. https://doi.org/10.3892/ijmm.16.6.1095
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