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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
December 2005 Volume 16 Issue 6

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Article

Thimerosal induces neuronal cell apoptosis by causing cytochrome c and apoptosis-inducing factor release from mitochondria

Leman Yel, Lorrel E. Brown, Kevin Su, Sastry Gollapudi, Sudhir Gupta
Pages: 971-977
Published online on: 01 December 2005

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Time-dependent RNA degradation affecting cDNA array quality in spontaneous canine tumours sampled using standard surgical procedures

Henrik Von Euler, Reza Khoshnoud, Qimin He, Aida Khoshnoud, Tommy Fornander, Lars-Erik Rutqvist, Sven Skog
Pages: 979-985
Published online on: 01 December 2005

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Article

Activation of ectopic Oct-4 and Rex-1 promoters in human amniotic fluid cells

Karlin R. Karlmark, Angelika Freilinger, Erika Marton, Margit Rosner, Gert Lubec, Markus Hengstschläger
Pages: 987-992
Published online on: 01 December 2005

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Article

Anti-angiogenic effects of Hypericin-photodynamic therapy in combination with Celebrex® in the treatment of human nasopharyngeal carcinoma

Karen Kar Lye Yee, Khee Chee Soo, Malini Olivo
Pages: 993-1002
Published online on: 01 December 2005

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Article

Identification of regions of α-catenin required for desmosome organization in epithelial cells

Tamotsu Taniguchi, Mutsumi Miyazaki, Yayoi Miyashita, Terukatsu Arima, Masayuki Ozawa
Pages: 1003-1008
Published online on: 01 December 2005

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Article

Neurite extension of DRG neurons by gicerin expression is enhanced by nerve growth factor

Satoshi Hiroi, Eiichi Taira, Kazushige Ogawa, Yasuhiro Tsukamoto
Pages: 1009-1014
Published online on: 01 December 2005

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Article

Mutated-leptin gene transfer induces increases in body weight by electroporation and hydrodynamics-based gene delivery in mice

Lan Xiang, Atsushi Murai, Tatsuo Muramatsu
Pages: 1015-1020
Published online on: 01 December 2005

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Article

Neuropeptides B and W enhance the growth of human adrenocortical carcinoma-derived NCI-H295 cells by exerting MAPK p42/p44-mediated proliferogenic and antiapoptotic effects

Paola G. Andreis, Marcin Rucinski, Giuliano Neri, Maria Teresa Conconi, Lucia Petrelli, Pier Paolo Parnigotto, Ludwik K. Malendowicz, Gastone G. Nussdorfer
Pages: 1021-1028
Published online on: 01 December 2005

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Article

Antioxidative role of urinary trypsin inhibitor in acute lung injury induced by lipopolysaccharide

Ken-Ichiro Inoue, Hirohisa Takano, Rie Yanagisawa, Miho Sakurai, Akinori Shimada, Hiroyuki Sato, Yoji Kato, Toshikazu Yoshikawa
Pages: 1029-1033
Published online on: 01 December 2005

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Article

A novel water-soluble vitamin E derivative protects against aspirin-induced gastric mucosal injury in rats

Yutaka Isozaki, Norimasa Yoshida, Hiroshi Ichikawa, Masaaki Kuroda, Satoshi Kokura, Yuji Naito, Takeshi Okanoue, Toshikazu Yoshikawa
Pages: 1035-1040
Published online on: 01 December 2005

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Article

Application of flow cytometry to molecular medicine: Detection of tumor necrosis factor-related apoptosis-inducing ligand receptors in acute myeloid leukaemia blasts

Alessandra Cappellini, Irina Mantovani, Pier Luigi Tazzari, Tiziana Grafone, Giovanni Martinelli, Lucio Cocco, Alberto M. Martelli
Pages: 1041-1048
Published online on: 01 December 2005

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Article

Overexpression of RGPR-p117 enhances regucalcin gene expression in cloned normal rat kidney proximal tubular epithelial cells

Natsumi Sawada, Masayoshi Yamaguchi
Pages: 1049-1055
Published online on: 01 December 2005

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Article

Carotid arteriotomy induces different temporal gene expression profiles in normotensive and hypertensive rat strains

Amalia Forte, Umberto Galderisi, Marisa De Feo, Cesare Quarto, Attilio Renzulli, Liberato Berrino, Francesco Rossi, Antonino Cascino, Marilena Cipollaro
Pages: 1057-1064
Published online on: 01 December 2005

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Article

Endogenous p63 acts as a survival factor for tumour cells of SCCHN origin

Niklas Thurfjell, Philip J. Coates, Borek Vojtesek, Parvis Benham-Motlagh, Michael Eisold, Karin Nylander
Pages: 1065-1070
Published online on: 01 December 2005

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Article

Vitamin B6 suppresses NF-κB activation in LPS-stimulated mouse macrophages

Noriyuki Yanaka, Taka-Aki Koyama, Shun-Ichiro Komatsu, Eri Nakamura, Mayumi Kanda, Norihisa Kato
Pages: 1071-1075
Published online on: 01 December 2005

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Article

Laughter therapy modulates the parameters of renin-angiotensin system in patients with type 2 diabetes

Uddin Mohammad Nasir, Shizuko Iwanaga, A. H.M. Nurun Nabi, Osamu Urayama, Keiko Hayashi, Takashi Hayashi, Koichi Kawai, Afroza Sultana, Kazuo Murakami, Fumiaki Suzuki
Pages: 1077-1081
Published online on: 01 December 2005

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Article

The influence of Celecoxib on matrix synthesis by chondrocytes under mechanical stress in vitro

Seiji Iimoto, Shohei Watanabe, Toshiaki Takahashi, Akira Shimizu, Haruyasu Yamamoto
Pages: 1083-1088
Published online on: 01 December 2005

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Article

Effects of a medium-chain triglyceride:fish oil emulsion administered intravenously to ω3 fatty acid-depleted rats on cationic fluxes in aortic rings

Philippe Courtois, Karim Louchami, Laurence Portois, Jean-Michel Chardigny, Abdullah Sener, Yvon S. Carpentier, Willy J. Malaisse
Pages: 1089-1093
Published online on: 01 December 2005

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Article

Diosgenin, a plant steroid, induces apoptosis in COX-2 deficient K562 cells with activation of the p38 MAP kinase signalling and inhibition of NF-κB binding

Bertrand Liagre, Julian Bertrand, David Y. Leger, Jean-Louis Beneytout
Pages: 1095-1101
Published online on: 01 December 2005

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Review

WNT2B: Comparative integromics and clinical applications (Review)

Masaru Katoh
Pages: 1103-1108
Published online on: 01 December 2005

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Article

Immune modulatory effects of Prunella vulgaris L. on monocytes/macrophages

Xuya Fang, Mabel Man-Shan Yu, Wai-Hung Yuen, Sze Yong Zee, Raymond Chuen-Chung Chang
Pages: 1109-1116
Published online on: 01 December 2005

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Article

IL-1 receptor antagonist attenuates MAP kinase/AP-1 activation and MMP1 expression in UVA-irradiated human fibroblasts induced by culture medium from UVB-irradiated human skin keratinocytes

Xiaoyong Wang, Zhigang Bi, Wenming Chu, Yinsheng Wan
Pages: 1117-1124
Published online on: 01 December 2005

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Article

Interactive effects of histone deacetylase inhibitors and TRAIL on apoptosis in human leukemia cells: Involvement of both death receptor and mitochondrial pathways

Sharmila Shankar, Thiyam R. Singh, Tamer E. Fandy, Thitidaj Luetrakul, Douglas D. Ross, Rakesh K. Srivastava
Pages: 1125-1138
Published online on: 01 December 2005

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Article

Lovastatin stimulates p75 TNF receptor (TNFR2) expression in primary human endothelial cells

Tobias Nübel, Steffen Schmitt, Bernd Kaina, Gerhard Fritz
Pages: 1139-1145
Published online on: 01 December 2005

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Article

Diagnostic value of 14-3-3β immunoblot and T-tau/P-tau ratio in clinically suspected Creutzfeldt-Jakob disease

Kaj Blennow, Annica Johansson, Henrik Zetterberg
Pages: 1147-1149
Published online on: 01 December 2005

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Article

HFE gene mutations in Polish patients with disturbances of iron metabolism: An initial assessment

Katarzyna Sikorska, Krzysztof Piotr Bielawski, Piotr Stalke, Elzbieta Anna Lakomy, Zofia Michalska, Krystyna Witczak-Malinowska, Tomasz Romanowski
Pages: 1151-1156
Published online on: 01 December 2005

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Article

Antiproliferative and apoptosis-inducing activity of Brucea javanica extract on human carcinoma cells

Fung Yi Lau, Chung Hin Chui, Roberto Gambari, Stanton Hon Lung Kok, Kin Luen Kan, Gregory Yin Ming Cheng, Raymond Siu Ming Wong, Ivy Tuang Ngo Teo, Chor Hing Cheng, Thomas Shek Kwong Wan, Albert Sun Chi Chan, Johnny Cheuk On Tang
Pages: 1157-1162
Published online on: 01 December 2005

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Article

Mutation screening of three candidate genes, ELOVL5, SMAP1 and GLULD1 in autosomal recessive retinitis pigmentosa

Isabel Barragan, Irene Marcos, Salud Borrego, Guillermo Antiñolo
Pages: 1163-1167
Published online on: 01 December 2005

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Article

Aberrant expression of FGFRL1, a novel FGF receptor, in ovarian tumors

Christof Schild, Beat Trueb
Pages: 1169-1173
Published online on: 01 December 2005

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Article

Mutational risk in highly repetitive exon ORF15 of the RPGR multidisease gene is not associated with haplotype background

Felix K. Jacobi, Daniela Karra, Martina Broghammer, Nikolaus Blin, Carsten M. Pusch
Pages: 1175-1178
Published online on: 01 December 2005

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Article

Conditionally replicative adenovirus vector carrying TRAIL gene for enhanced oncolysis of human hepatocellular carcinoma

Xun Ye, Qin Lu, Yi Zhao, Zhen Ren, Xiao Wei Ren, Qi Hong Qiu, Yong Tong, Min Liang, Fang Hu, Hong Zhuan Chen
Pages: 1179-1184
Published online on: 01 December 2005

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Journal Cover
February-2026 Volume 57 Issue 2

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

miR‑205: A dual regulator of angiogenesis in health and disease (Review)

Maria Oltra, Miriam Martínez‑Santos, Maria Ybarra, Maria Pires, Chiara Ceresoni, Clara Gomis‑Coloma, Cristina Medina‑Trillo, Javier Sancho, Jorge Barcia
Article Number: 51
Published online on: 29 December 2025

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Astragaloside IV: A multipotent phytochemical for treating fibrotic diseases (Review)

Mingyu Wu, Ke Li, Jiabin Wu, Qiuyu Zhang, Xiaotong Ma, Wei Dai, Haoyang Gao, Xianyi Ding, Wenhong Wang, Weihua Xiao
Article Number: 50
Published online on: 24 December 2025

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Activating transcription factors: Orchestrators of macrophage biology in pathological settings (Review)

Yue-Chen Liu, Jia-Wei Zhao, Xiong-Tao Yue, Qi-Jie Chen, Shan-Jie Rong, Shi-Wei Liu, Fei Sun, Chun-Liang Yang, Cong-Yi Wang
Article Number: 49
Published online on: 24 December 2025

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Role of SIRT3 in digestive system diseases and therapeutic prospects (Review)

Jiajia Li, Qian Liu, Shun Yao, Xin Li, Li Zhang, Yongfeng Wang, Guorong Wen, Jiaxing An, Hai Jin, Biguang Tuo
Article Number: 48
Published online on: 22 December 2025

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Recombinant ADAMTS‑1 promotes muscle regeneration accompanied by downregulation of Notch signaling

Jin-Hwa Kim, Sang-Hyup Lee, Sang-Yoon Kim, Jeong-Won Kim, Ji-Soo Jeong, Eun-Hye Chung, Su-Ha Lee, Chang-Yeop Kim, Bong-Keun Choi, Je-Won Ko, Tae-Won Kim
Article Number: 47
Published online on: 22 December 2025

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A comprehensive review on pain: Model, target, therapy, and prospect (Review)

Chenyu Chang, Xutao Wu, Kejia Liu, Lei Wang, Mozili Adu, Qingyuan Lin, Huilian Huang, Qinge Ma, Rongrui Wei, Xiaoyun Wang, Wenmin Liu
Article Number: 46
Published online on: 17 December 2025

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Retraction Open Access

[Retracted] Curculigoside attenuates myocardial ischemia‑reperfusion injury by inhibiting the opening of the mitochondrial permeability transition pore

Yanbing Zhao, Yuxuan Guo, Yuqiong Chen, Shuang Liu, Nan Wu, Dalin Jia
Article Number: 45
Published online on: 15 December 2025

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Nanomaterials and exercise interventions: A synergistic approach for atherosclerosis therapy (Review)

Quanquan Zhou, Ge‑Lin Zhang, Weitong Sun, Jiayi Cai, Li-Hua Yu
Article Number: 44
Published online on: 10 December 2025

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Article Open Access

Selective autophagic degradation of glycolytic activator PFKFB3 contributes to maintaining intestinal epithelial barrier in inflammatory bowel disease

Yiyang Pan, Feng Yang, Liucan Wang, Tianshu Yang, Guangsheng Du, Cong Xu, Hua Yang, Min Yu, Weidong Xiao
Article Number: 43
Published online on: 10 December 2025

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Lactylation‑mediated ferroptosis: A novel mechanism and therapeutic prospects in human diseases (Review)

Zhengjun Lin, Yugang Zou, Songzhu Zou, Kunming Wen
Article Number: 42
Published online on: 08 December 2025

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Dual role of lactate in ferroptosis: Mechanisms, pathophysiology and therapeutic opportunities (Review)

Qian Yu, Yu Kuang, Jie He, Li Yang, Xinjie Li, Hao Yu
Article Number: 41
Published online on: 08 December 2025

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Retraction Open Access

[Retracted] MicroRNA‑493‑5p promotes apoptosis and suppresses proliferation and invasion in liver cancer cells by targeting VAMP2

Guannan Wang, Xiaosan Fang, Meng Han, Xiaoming Wang, Qiang Huang
Article Number: 40
Published online on: 08 December 2025

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Article Open Access

FGF4 alleviates the lung cell damage caused by high glucose via AMPK‑PGC‑1 signaling axis in vitro and in vivo

Qiujuan Fu, Yongfang Ou, Qin Wu, Jue Gong, Feixia Li, Tuxing Wang, Zhitai Lin, Kejie Huang, Jianlong Xie
Article Number: 39
Published online on: 05 December 2025

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STOML2 interacts with PHB to activate the MEK/ERK signaling pathway and mediates autophagy‑related proteins in the progression of hepatocellular carcinoma

Haoyang Hu, Haozhe Zhang, Shuai Han, Jianli Chen, Ying Xie
Article Number: 38
Published online on: 04 December 2025

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HMGB1 mediates low-dose ionizing radiation-induced Wnt/β-catenin activation in SRA01/04 cells: Mechanistic clues to early cataractogenesis

Ping Wang, Chunnan Piao, Dong Yan, Yingxue He, Yaru Li, Li Fan, Mei Tian
Article Number: 37
Published online on: 04 December 2025

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FBXO22 promotes hepatocellular carcinoma progression via paracrine myo‑inositol‑induced M2‑type polarization of macrophages

Liangliang Bai, Jing Xiong, Sihai Chen, Jiahao Hu, Meixia Zhang, Bimin Li, Jing Hu, Mingyan He
Article Number: 36
Published online on: 02 December 2025

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Branched‑chain amino acid metabolism and bone metabolism: Implications for osteoporosis pathogenesis and therapeutic strategies (Review)

Qi Xiao, Haimin Zeng, Ruhui Yang, Yuxin Zhan, Fangzhen Lin, Bofan Chen, Xiang Chen
Article Number: 35
Published online on: 02 December 2025

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Mitochondria-associated endoplasmic reticulum membranes: Emerging regulators of cardiac microvascular ischemia/reperfusion injury (Review)

Yan Wang, Baowei Feng, Yanting Wu, Zongle Sun, Hao Yuan, Wei Chen, Chang Zhao, Zhi Liu
Article Number: 34
Published online on: 02 December 2025

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Role of matrix metalloproteinases in the invasion of glioblastoma and drug interventions (Review)

Bohao Zheng, Ying Han, Haiying Zhang
Article Number: 33
Published online on: 01 December 2025

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Review

Bridging bench to bedside: Exosome‑based strategies for endometriosis diagnosis and treatment (Review)

Wanmeng Chen, Yujiu Ma, Xudong Zhang, Siwen Zhang, Shanshan Wu, Yimeng Lu, Jichun Tan
Article Number: 32
Published online on: 01 December 2025

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Retraction Open Access

[Retracted] miR‑381 functions as a tumor suppressor by targeting ETS1 in pancreatic cancer

Guanen Qiao, Jing Li, Jun Wang, Zhaoyang Wang, Wei Bian
Article Number: 31
Published online on: 01 December 2025

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Journal Cover
March-2026 Volume 57 Issue 3

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

Role and mechanisms of ferroptosis in cognitive impairment: From molecular pathways to therapeutic targets (Review)

Shenghui Ge, Deyue Kong, Shuyue Fan, Yi Luo, Xiao Yin, Zehua Jin, Wenqing Xia, Jianhua Ma
Article Number: 54
Published online on: 30 December 2025

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The GPR124‑Wnt‑PPARγ regulatory axis: Molecular mechanisms and therapeutic implications in chronic inflammatory diseases (Review)

Ming-Wang Cui, Si-Yu Tao, Tao Wen, Zhu-Ling Guo
Article Number: 53
Published online on: 30 December 2025

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Advances in RPGR gene therapy for X‑linked retinitis pigmentosa: From preclinical insights to clinical application (Review)

Yushan Long, Jia Qi, Wenliang Zhang, Huan Qin, Kai Yao
Article Number: 52
Published online on: 30 December 2025

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