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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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International Journal of Molecular Medicine

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
December 2005 Volume 16 Issue 6

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Article

Thimerosal induces neuronal cell apoptosis by causing cytochrome c and apoptosis-inducing factor release from mitochondria

Leman Yel, Lorrel E. Brown, Kevin Su, Sastry Gollapudi, Sudhir Gupta
Pages: 971-977
Published online on: 01 December 2005

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Article

Time-dependent RNA degradation affecting cDNA array quality in spontaneous canine tumours sampled using standard surgical procedures

Henrik Von Euler, Reza Khoshnoud, Qimin He, Aida Khoshnoud, Tommy Fornander, Lars-Erik Rutqvist, Sven Skog
Pages: 979-985
Published online on: 01 December 2005

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Article

Activation of ectopic Oct-4 and Rex-1 promoters in human amniotic fluid cells

Karlin R. Karlmark, Angelika Freilinger, Erika Marton, Margit Rosner, Gert Lubec, Markus Hengstschläger
Pages: 987-992
Published online on: 01 December 2005

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Article

Anti-angiogenic effects of Hypericin-photodynamic therapy in combination with Celebrex® in the treatment of human nasopharyngeal carcinoma

Karen Kar Lye Yee, Khee Chee Soo, Malini Olivo
Pages: 993-1002
Published online on: 01 December 2005

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Article

Identification of regions of α-catenin required for desmosome organization in epithelial cells

Tamotsu Taniguchi, Mutsumi Miyazaki, Yayoi Miyashita, Terukatsu Arima, Masayuki Ozawa
Pages: 1003-1008
Published online on: 01 December 2005

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Article

Neurite extension of DRG neurons by gicerin expression is enhanced by nerve growth factor

Satoshi Hiroi, Eiichi Taira, Kazushige Ogawa, Yasuhiro Tsukamoto
Pages: 1009-1014
Published online on: 01 December 2005

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Article

Mutated-leptin gene transfer induces increases in body weight by electroporation and hydrodynamics-based gene delivery in mice

Lan Xiang, Atsushi Murai, Tatsuo Muramatsu
Pages: 1015-1020
Published online on: 01 December 2005

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Article

Neuropeptides B and W enhance the growth of human adrenocortical carcinoma-derived NCI-H295 cells by exerting MAPK p42/p44-mediated proliferogenic and antiapoptotic effects

Paola G. Andreis, Marcin Rucinski, Giuliano Neri, Maria Teresa Conconi, Lucia Petrelli, Pier Paolo Parnigotto, Ludwik K. Malendowicz, Gastone G. Nussdorfer
Pages: 1021-1028
Published online on: 01 December 2005

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Article

Antioxidative role of urinary trypsin inhibitor in acute lung injury induced by lipopolysaccharide

Ken-Ichiro Inoue, Hirohisa Takano, Rie Yanagisawa, Miho Sakurai, Akinori Shimada, Hiroyuki Sato, Yoji Kato, Toshikazu Yoshikawa
Pages: 1029-1033
Published online on: 01 December 2005

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Article

A novel water-soluble vitamin E derivative protects against aspirin-induced gastric mucosal injury in rats

Yutaka Isozaki, Norimasa Yoshida, Hiroshi Ichikawa, Masaaki Kuroda, Satoshi Kokura, Yuji Naito, Takeshi Okanoue, Toshikazu Yoshikawa
Pages: 1035-1040
Published online on: 01 December 2005

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Article

Application of flow cytometry to molecular medicine: Detection of tumor necrosis factor-related apoptosis-inducing ligand receptors in acute myeloid leukaemia blasts

Alessandra Cappellini, Irina Mantovani, Pier Luigi Tazzari, Tiziana Grafone, Giovanni Martinelli, Lucio Cocco, Alberto M. Martelli
Pages: 1041-1048
Published online on: 01 December 2005

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Article

Overexpression of RGPR-p117 enhances regucalcin gene expression in cloned normal rat kidney proximal tubular epithelial cells

Natsumi Sawada, Masayoshi Yamaguchi
Pages: 1049-1055
Published online on: 01 December 2005

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Article

Carotid arteriotomy induces different temporal gene expression profiles in normotensive and hypertensive rat strains

Amalia Forte, Umberto Galderisi, Marisa De Feo, Cesare Quarto, Attilio Renzulli, Liberato Berrino, Francesco Rossi, Antonino Cascino, Marilena Cipollaro
Pages: 1057-1064
Published online on: 01 December 2005

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Article

Endogenous p63 acts as a survival factor for tumour cells of SCCHN origin

Niklas Thurfjell, Philip J. Coates, Borek Vojtesek, Parvis Benham-Motlagh, Michael Eisold, Karin Nylander
Pages: 1065-1070
Published online on: 01 December 2005

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Article

Vitamin B6 suppresses NF-κB activation in LPS-stimulated mouse macrophages

Noriyuki Yanaka, Taka-Aki Koyama, Shun-Ichiro Komatsu, Eri Nakamura, Mayumi Kanda, Norihisa Kato
Pages: 1071-1075
Published online on: 01 December 2005

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Article

Laughter therapy modulates the parameters of renin-angiotensin system in patients with type 2 diabetes

Uddin Mohammad Nasir, Shizuko Iwanaga, A. H.M. Nurun Nabi, Osamu Urayama, Keiko Hayashi, Takashi Hayashi, Koichi Kawai, Afroza Sultana, Kazuo Murakami, Fumiaki Suzuki
Pages: 1077-1081
Published online on: 01 December 2005

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Article

The influence of Celecoxib on matrix synthesis by chondrocytes under mechanical stress in vitro

Seiji Iimoto, Shohei Watanabe, Toshiaki Takahashi, Akira Shimizu, Haruyasu Yamamoto
Pages: 1083-1088
Published online on: 01 December 2005

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Article

Effects of a medium-chain triglyceride:fish oil emulsion administered intravenously to ω3 fatty acid-depleted rats on cationic fluxes in aortic rings

Philippe Courtois, Karim Louchami, Laurence Portois, Jean-Michel Chardigny, Abdullah Sener, Yvon S. Carpentier, Willy J. Malaisse
Pages: 1089-1093
Published online on: 01 December 2005

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Article

Diosgenin, a plant steroid, induces apoptosis in COX-2 deficient K562 cells with activation of the p38 MAP kinase signalling and inhibition of NF-κB binding

Bertrand Liagre, Julian Bertrand, David Y. Leger, Jean-Louis Beneytout
Pages: 1095-1101
Published online on: 01 December 2005

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Review

WNT2B: Comparative integromics and clinical applications (Review)

Masaru Katoh
Pages: 1103-1108
Published online on: 01 December 2005

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Article

Immune modulatory effects of Prunella vulgaris L. on monocytes/macrophages

Xuya Fang, Mabel Man-Shan Yu, Wai-Hung Yuen, Sze Yong Zee, Raymond Chuen-Chung Chang
Pages: 1109-1116
Published online on: 01 December 2005

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Article

IL-1 receptor antagonist attenuates MAP kinase/AP-1 activation and MMP1 expression in UVA-irradiated human fibroblasts induced by culture medium from UVB-irradiated human skin keratinocytes

Xiaoyong Wang, Zhigang Bi, Wenming Chu, Yinsheng Wan
Pages: 1117-1124
Published online on: 01 December 2005

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Article

Interactive effects of histone deacetylase inhibitors and TRAIL on apoptosis in human leukemia cells: Involvement of both death receptor and mitochondrial pathways

Sharmila Shankar, Thiyam R. Singh, Tamer E. Fandy, Thitidaj Luetrakul, Douglas D. Ross, Rakesh K. Srivastava
Pages: 1125-1138
Published online on: 01 December 2005

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Article

Lovastatin stimulates p75 TNF receptor (TNFR2) expression in primary human endothelial cells

Tobias Nübel, Steffen Schmitt, Bernd Kaina, Gerhard Fritz
Pages: 1139-1145
Published online on: 01 December 2005

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Article

Diagnostic value of 14-3-3β immunoblot and T-tau/P-tau ratio in clinically suspected Creutzfeldt-Jakob disease

Kaj Blennow, Annica Johansson, Henrik Zetterberg
Pages: 1147-1149
Published online on: 01 December 2005

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Article

HFE gene mutations in Polish patients with disturbances of iron metabolism: An initial assessment

Katarzyna Sikorska, Krzysztof Piotr Bielawski, Piotr Stalke, Elzbieta Anna Lakomy, Zofia Michalska, Krystyna Witczak-Malinowska, Tomasz Romanowski
Pages: 1151-1156
Published online on: 01 December 2005

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Article

Antiproliferative and apoptosis-inducing activity of Brucea javanica extract on human carcinoma cells

Fung Yi Lau, Chung Hin Chui, Roberto Gambari, Stanton Hon Lung Kok, Kin Luen Kan, Gregory Yin Ming Cheng, Raymond Siu Ming Wong, Ivy Tuang Ngo Teo, Chor Hing Cheng, Thomas Shek Kwong Wan, Albert Sun Chi Chan, Johnny Cheuk On Tang
Pages: 1157-1162
Published online on: 01 December 2005

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Article

Mutation screening of three candidate genes, ELOVL5, SMAP1 and GLULD1 in autosomal recessive retinitis pigmentosa

Isabel Barragan, Irene Marcos, Salud Borrego, Guillermo Antiñolo
Pages: 1163-1167
Published online on: 01 December 2005

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Article

Aberrant expression of FGFRL1, a novel FGF receptor, in ovarian tumors

Christof Schild, Beat Trueb
Pages: 1169-1173
Published online on: 01 December 2005

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Article

Mutational risk in highly repetitive exon ORF15 of the RPGR multidisease gene is not associated with haplotype background

Felix K. Jacobi, Daniela Karra, Martina Broghammer, Nikolaus Blin, Carsten M. Pusch
Pages: 1175-1178
Published online on: 01 December 2005

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Article

Conditionally replicative adenovirus vector carrying TRAIL gene for enhanced oncolysis of human hepatocellular carcinoma

Xun Ye, Qin Lu, Yi Zhao, Zhen Ren, Xiao Wei Ren, Qi Hong Qiu, Yong Tong, Min Liang, Fang Hu, Hong Zhuan Chen
Pages: 1179-1184
Published online on: 01 December 2005

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Journal Cover
January-2026 Volume 57 Issue 1

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

FK506‑binding proteins as emerging bridges linking proteostasis to multi‑system pathogenesis and therapeutic strategies (Review)

Zhi Li, Xiaolei Liu, Hesong Zeng
Article Number: 30
Published online on: 24 November 2025

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Retraction Open Access

[Retracted] Suppression of SIK1 by miR‑141 in human ovarian cancer cell lines and tissues

Jin-Long Chen, Fang Chen, Ting-Ting Zhang, Nai-Fu Liu
Article Number: 29
Published online on: 24 November 2025

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Article Open Access

METTL3 inhibits LINC00312 to suppress osteoporosis progression in a YTHDF2‑dependent manner

Yang Wang, Yihao Tian, Gang Yao
Article Number: 28
Published online on: 20 November 2025

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Decoding structural birth defects through genomic landscapes: Innovative frameworks for diagnosis (Review)

Ruihao Xu, Haoming Ren, Zhengwei Yuan, Wanqi Huang, Hui Gu
Article Number: 27
Published online on: 20 November 2025

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MOTS‑c protects against placental injury via Nrf2 activation in hypoxia‑induced intrauterine growth restriction mice

Dan Chen, Hui-Min Zhao, Xiao-Lin Sun, Zhi-Xuan Xing, Sheng-Peng Li, Shuai-Chao Li, Ya-Xian Wu, Qing-Feng Pang, Jian-Feng Huang
Article Number: 26
Published online on: 18 November 2025

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Synergistic effects of Akebia saponin D and Semaglutide on diabetic nephropathy and osteoporosis via the Klotho‑p53 signaling axis

Qian Zhang, Dan Wang, Hongxia Jia, Zongji Zheng, Liyan Lin, Linna Li, Ling Wang, Yaoming Xue
Article Number: 25
Published online on: 18 November 2025

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Retraction Open Access

[Retracted] MicroRNA‑103 modulates tumor progression by targeting KLF7 in non‑small cell lung cancer

Ke Li, Conghu Yuan
Article Number: 24
Published online on: 17 November 2025

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Article

Comparative analysis of pan MHC‑I epitopes immunoreactivity on Hantaan virus nucleocapsid protein

Zhikui Li, Weijie Ding, Yubo Sun, Chenfeng Tian, Shuaishuai Fu, Fei Shi, Zhenchi Fang, Yuanzhe Li, Jianchang Li, Sirui Cai, Haobo Kang, Baozeng Sun, Junqi Zhang, Yuanjie Sun, Shuya Yang, Yusi Zhang, Chunmei Zhang, Yun Zhang, Xiyang Zhang, Kun Yang, Dongbo Jiang
Article Number: 23
Published online on: 14 November 2025

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Human papillomavirus E7 inhibits immune responses in keratinocytes by activating HTRA1‑mediated mitophagy

Boya Zhang, Defeng Kong, Siji Chen, Xuewu Sun, Hao Cheng
Article Number: 22
Published online on: 14 November 2025

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Article Open Access

Targeting p38 MAPK signaling pathway: 
Quercetin as a novel therapy for TMJ synovitis

Mosha Cheng, Yuhe Guan, Xiaotao Xin, Xin Yi, Yi Liu
Article Number: 21
Published online on: 13 November 2025

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Review Open Access

Lipid droplets in astrocytes: Key organelles for CNS homeostasis and disease (Review)

Yuchen Wang, Boxuan Wang, Jinchao Hou, Xiaodong Huo, Chenlin Liu, Ruili Guan, Honggang Chen, Yang Zhou, Jianbin Zhang, Congcong Zhuang, Yuankang Zou
Article Number: 20
Published online on: 13 November 2025

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Copper dyshomeostasis and cardiovascular disease: Molecular mechanisms and new strategies for targeted intervention with cuproptosis (Review)

Peiyu Li, Yinghui Li, Qian Meng, Jie Wang, Kun Wang, Sumin Yang
Article Number: 19
Published online on: 13 November 2025

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Elevated FTO alleviates sepsis‑induced acute kidney injury by regulating macrophage inflammatory phenotypes

Xiaona Chen, Ziqi Sun, Jiabo Chen, Jinquan Zhang, Zeyu Liu, Zhengzheng Yan, Quan Li, Zhixia Chen
Article Number: 18
Published online on: 12 November 2025

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Correction Open Access

[Corrigendum]  Suppression of PAX6 promotes cell proliferation and inhibits apoptosis in human retinoblastoma cells

Bo Meng, Yisong Wang, Bin Li
Article Number: 17
Published online on: 10 November 2025

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Microbial short chain fatty acids: Effective histone deacetylase inhibitors in immune regulation (Review)

Jing Wang, Qin Zhao, Shuwan Zhang, Jia Liu, Xingyue Fan, Bin Han, Yaqin Hou, Xiaopeng Ai
Article Number: 16
Published online on: 05 November 2025

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High‑fat diet and cognitive dysfunction: Mechanistic insights into diet‑induced neurodegeneration (Review)

Min You, Fan Wu, Feng Xiong, Xue-Fei Hu, Huan Wu, Li Zhou, Hong-Xing Zhang
Article Number: 15
Published online on: 05 November 2025

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Article Open Access

ROCK inhibition promotes axon and myelin regeneration via PI3K/Akt/GSK3β in a mouse sciatic nerve injury model

Shuang Dou, Zhijun Li, Boyao Zheng, Zhenyu Ren, Hai Wang, Qing Zuo, Fang Fang, Yuehong Zhuang
Article Number: 14
Published online on: 05 November 2025

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Review Open Access

Mechanisms of mTORC1 and GCN2 amino acid sensing pathways in tumorigenesis and metastatic progression (Review)

Chaowei Zhang, Yuxuan Han, Weiyi Yao, Qing Hong, Na Chen
Article Number: 13
Published online on: 04 November 2025

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β‑hydroxybutyric acid as a potential therapeutic metabolite for type 2 diabetes mellitus (Review)

Xianyi Ding, Jiabin Wu, Lian Wang, Ke Li, Haoyang Gao, Mingyu Wu, Qiuyu Zhang, Ruonan Han, Wenhong Wang, Weihua Xiao
Article Number: 12
Published online on: 03 November 2025

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Review

Histone lactylation: Unveiling a novel pathway for the impact of lactate on physiological and pathological processes (Review)

Xunjie Jian, Chang Cheng, Wenjie Lu, Hui Peng, Diqi Yang
Article Number: 11
Published online on: 03 November 2025

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Review Open Access

Interpretation of the molecular mechanism and therapeutic potential of microRNA‑155 in cardiovascular and cerebrovascular diseases (Review)

Xitong Zhao, Pengqin Wang
Article Number: 10
Published online on: 03 November 2025

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Expression of Concern Open Access

[Expression of Concern]  CDKN2A (p16INK4A) affects the anti‑tumor effect of CDK inhibitor in somatotroph adenomas

Yiyuan Chen, Zhenye Li, Qiuyue Fang, Hongyun Wang, Chuzhong Li, Hua Gao, Yazhuo Zhang
Article Number: 9
Published online on: 29 October 2025

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Article Open Access

TWEAK modulates the characteristics of periodontal ligament stem cells via the Fn14/NF‑κB pathway

Linlin Xiao, Man Qu, Lulu Chen, Mingli Xiang, Qian Long, Jianguo Liu, Xiaoyan Guan, Chengcheng Liao
Article Number: 8
Published online on: 27 October 2025

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Review Open Access

Harnessing copper: Innovative approaches to combat neurodegenerative diseases and cancer (Review)

Tao Duan, Hanhai Mao, Xingyue Jiang, Ying Tian, Jidong Zhang, Jun Tan
Article Number: 7
Published online on: 27 October 2025

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Retraction Open Access

[Retracted] Effects of miR‑106b‑3p on cell proliferation and epithelial‑mesenchymal transition, and targeting of ZNRF3 in esophageal squamous cell carcinoma

Guanen Qiao, Chenguang Dai, Yang He, Junjie Shi, Chunfang Xu
Article Number: 6
Published online on: 27 October 2025

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Review Open Access

Immune and metabolic remodeling following bariatric surgery: Implications for targeted immunotherapy (Review)

Yiming Shao, Ke Song, Ruixin Yu, He Xiao, Chengjun Li, Yuling Deng, Yuan Zhang, Yixing Ren
Article Number: 5
Published online on: 24 October 2025

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Exportin 1 inhibitor KPT‑330 reverses oxaliplatin resistance via p53 nuclear retention in colorectal cancer

Chuanxi Lai, Xiya Jia, Yiyi Chen, Kangke Chen, Fei Wang, Qiqi Zhang, Xiaonan Xiang, Zhe-Sheng Chen, Lingna Xu, Sheng Dai
Article Number: 4
Published online on: 23 October 2025

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Targeting of CIRP attenuates osteoarthritis progression via suppressing TLR4/NF‑κB/NLRP3 signaling axis

Weichao Sun, Yi Liao, Jianguo Feng, Jianhui Liang, Qifei He, Yinxing Cui, Dixi Huang, Houyin Shi, Wei You, Wei Sun, Qian Yi
Article Number: 3
Published online on: 23 October 2025

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Review

Importance of B cells (Review)

Zhiyuan Liu, Haoran Dai, Xiaoyu Cui, Yeping Liu, Zhaocheng Dong
Article Number: 2
Published online on: 22 October 2025

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Retraction Open Access

[Retracted] Hypoxic preconditioned bone mesenchymal stem cells ameliorate spinal cord injury in rats via improved survival and migration

Weiheng Wang, Xiaodong Huang, Wenbo Lin, Yuanyuan Qiu, Yunfei He, Jiangming Yu, Yanhai Xi, Xiaojian Ye
Article Number: 1
Published online on: 22 October 2025

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February-2026 Volume 57 Issue 2

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Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Article Open Access

STOML2 interacts with PHB to activate the MEK/ERK signaling pathway and mediates autophagy‑related proteins in the progression of hepatocellular carcinoma

Haoyang Hu, Haozhe Zhang, Shuai Han, Jianli Chen, Ying Xie
Article Number: 38
Published online on: 04 December 2025

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Article Open Access

HMGB1 mediates low-dose ionizing radiation-induced Wnt/β-catenin activation in SRA01/04 cells: Mechanistic clues to early cataractogenesis

Ping Wang, Chunnan Piao, Dong Yan, Yingxue He, Yaru Li, Li Fan, Mei Tian
Article Number: 37
Published online on: 04 December 2025

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Article Open Access

FBXO22 promotes hepatocellular carcinoma progression via paracrine myo‑inositol‑induced M2‑type polarization of macrophages

Liangliang Bai, Jing Xiong, Sihai Chen, Jiahao Hu, Meixia Zhang, Bimin Li, Jing Hu, Mingyan He
Article Number: 36
Published online on: 02 December 2025

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Review Open Access

Branched‑chain amino acid metabolism and bone metabolism: Implications for osteoporosis pathogenesis and therapeutic strategies (Review)

Qi Xiao, Haimin Zeng, Ruhui Yang, Yuxin Zhan, Fangzhen Lin, Bofan Chen, Xiang Chen
Article Number: 35
Published online on: 02 December 2025

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Review Open Access

Mitochondria-associated endoplasmic reticulum membranes: Emerging regulators of cardiac microvascular ischemia/reperfusion injury (Review)

Yan Wang, Baowei Feng, Yanting Wu, Zongle Sun, Hao Yuan, Wei Chen, Chang Zhao, Zhi Liu
Article Number: 34
Published online on: 02 December 2025

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Review Open Access

Role of matrix metalloproteinases in the invasion of glioblastoma and drug interventions (Review)

Bohao Zheng, Ying Han, Haiying Zhang
Article Number: 33
Published online on: 01 December 2025

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Review

Bridging bench to bedside: Exosome‑based strategies for endometriosis diagnosis and treatment (Review)

Wanmeng Chen, Yujiu Ma, Xudong Zhang, Siwen Zhang, Shanshan Wu, Yimeng Lu, Jichun Tan
Article Number: 32
Published online on: 01 December 2025

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Retraction Open Access

[Retracted] miR‑381 functions as a tumor suppressor by targeting ETS1 in pancreatic cancer

Guanen Qiao, Jing Li, Jun Wang, Zhaoyang Wang, Wei Bian
Article Number: 31
Published online on: 01 December 2025

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