Aberrant expression of FGFRL1, a novel FGF receptor, in ovarian tumors

  • Authors:
    • Christof Schild
    • Beat Trueb
  • View Affiliations

  • Published online on: December 1, 2005     https://doi.org/10.3892/ijmm.16.6.1169
  • Pages: 1169-1173
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Abstract

FGFRL1 is a novel member of the FGF receptor family. It is expressed at very low levels in a great variety of cell lines and at relatively high levels in SW1353 chondrosarcoma cells, MG63 osteosarcoma cells and A204 rhabdomyosarcoma cells. Screening of 241 different human tumors with the help of a cancer profiling array suggested major alterations in the relative expression of FGFRL1 in ovarian tumors. Five distinct ovary tumors were therefore analyzed by quantitative and competitive PCR. Several tumors were found to exhibit a significant decrease in the expression of FGFRL1 in the tumor tissue relative to the matched control tissue. One ovarian tumor showed a 25-fold increase in the relative expression. Since FGFRL1 appears to be involved in the control of cell proliferation and differentiation, its aberrant expression might contribute to the development and progression of ovarian tumors.

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December 2005
Volume 16 Issue 6

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Schild C and Schild C: Aberrant expression of FGFRL1, a novel FGF receptor, in ovarian tumors. Int J Mol Med 16: 1169-1173, 2005
APA
Schild, C., & Schild, C. (2005). Aberrant expression of FGFRL1, a novel FGF receptor, in ovarian tumors. International Journal of Molecular Medicine, 16, 1169-1173. https://doi.org/10.3892/ijmm.16.6.1169
MLA
Schild, C., Trueb, B."Aberrant expression of FGFRL1, a novel FGF receptor, in ovarian tumors". International Journal of Molecular Medicine 16.6 (2005): 1169-1173.
Chicago
Schild, C., Trueb, B."Aberrant expression of FGFRL1, a novel FGF receptor, in ovarian tumors". International Journal of Molecular Medicine 16, no. 6 (2005): 1169-1173. https://doi.org/10.3892/ijmm.16.6.1169