The -1438A/G polymorphism in the 5-hydroxytryptamine receptor 2A gene is related to hyperuricemia, increased γ-glutamyl transpeptidase and decreased high-density lipoprotein cholesterol level in the Japanese population: A prospective cohort study over 5 years

  • Authors:
    • Yasushi Suwazono
    • Etsuko Kobayashi
    • Mirei Uetani
    • Katsuyuki Miura
    • Yuko Morikawa
    • Masao Ishizaki
    • Teruhiko Kido
    • Hideaki Nakagawa
    • Koji Nogawa
  • View Affiliations

  • Published online on: January 1, 2006     https://doi.org/10.3892/ijmm.17.1.77
  • Pages: 77-82
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Abstract

This prospective cohort study in Japanese workers examined the relationship between the -1438A/G polymorphism in the 5-hydroxytryptamine receptor 2A gene and the development of positive findings for various life-style-related disorders. This study over the 5-year period, 1997-2002, included observations of several disorders in cohorts ranging between 560-1023 for males and 477-735 for females who had negative findings for each disorder at baseline. The criteria for development of the disorders were: hypertension, systolic blood pressure ≥140 mmHg or dia-stolic blood pressure ≥90 mmHg or taking antihypertensive medication; overweight, body mass index (BMI) ≥25 kg/m2; obesity, BMI ≥30 kg/m2; new onset of cerebral stroke; metabolic abnormalities, glycosylated hemoglobin A1c >6.0%, total cholesterol ≥240 mg/dl, high-density lipoprotein cholesterol <40 mg/dl, uric acid >7.0 mg/dl, γ-glutamyl transpeptidase ≥60 IU/l in males and ≥30 IU/l in females. Pooled logistic regression analyses were performed using the -1438A/G genotype and other potential factors as covariates. The odds ratios to AA genotype were significant for uric acid (GG, 0.52; AG, 0.59), obesity (AG, 0.24) in males and for high-density lipoprotein cholesterol (GG, 0.11; AG, 0.36), γ-glutamyl transpeptidase (GG, 0.53; AG, 0.62) and total cholesterol (GG, 1.84) in females. The present study is the first prospective cohort investigation to demonstrate that the -1438G allele has a protective effect against the development of a range of cardiovascular and metabolic disorders. This study indicates that the -1438A/G polymorphism is an independent factor for various disorders in the general Japanese population and suggests that targeting of this polymorphism may be beneficial for preventing these disorders in Japan.

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January 2006
Volume 17 Issue 1

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Suwazono Y, Kobayashi E, Uetani M, Miura K, Morikawa Y, Ishizaki M, Kido T, Nakagawa H and Nogawa K: The -1438A/G polymorphism in the 5-hydroxytryptamine receptor 2A gene is related to hyperuricemia, increased γ-glutamyl transpeptidase and decreased high-density lipoprotein cholesterol level in the Japanese population: A prospective cohort study over 5 years. Int J Mol Med 17: 77-82, 2006
APA
Suwazono, Y., Kobayashi, E., Uetani, M., Miura, K., Morikawa, Y., Ishizaki, M. ... Nogawa, K. (2006). The -1438A/G polymorphism in the 5-hydroxytryptamine receptor 2A gene is related to hyperuricemia, increased γ-glutamyl transpeptidase and decreased high-density lipoprotein cholesterol level in the Japanese population: A prospective cohort study over 5 years. International Journal of Molecular Medicine, 17, 77-82. https://doi.org/10.3892/ijmm.17.1.77
MLA
Suwazono, Y., Kobayashi, E., Uetani, M., Miura, K., Morikawa, Y., Ishizaki, M., Kido, T., Nakagawa, H., Nogawa, K."The -1438A/G polymorphism in the 5-hydroxytryptamine receptor 2A gene is related to hyperuricemia, increased γ-glutamyl transpeptidase and decreased high-density lipoprotein cholesterol level in the Japanese population: A prospective cohort study over 5 years". International Journal of Molecular Medicine 17.1 (2006): 77-82.
Chicago
Suwazono, Y., Kobayashi, E., Uetani, M., Miura, K., Morikawa, Y., Ishizaki, M., Kido, T., Nakagawa, H., Nogawa, K."The -1438A/G polymorphism in the 5-hydroxytryptamine receptor 2A gene is related to hyperuricemia, increased γ-glutamyl transpeptidase and decreased high-density lipoprotein cholesterol level in the Japanese population: A prospective cohort study over 5 years". International Journal of Molecular Medicine 17, no. 1 (2006): 77-82. https://doi.org/10.3892/ijmm.17.1.77