Association of a microsomal triglyceride transfer protein gene polymorphism with blood pressure in Japanese women

  • Authors:
    • Yoshiji Yamada
    • Fujiko Ando
    • Hiroshi Shimokata
  • View Affiliations

  • Published online on: January 1, 2006     https://doi.org/10.3892/ijmm.17.1.83
  • Pages: 83-88
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Abstract

Genetic variants of the microsomal triglyceride transfer protein (MTP) have been associated with the serum concentration of low density lipoprotein-cholesterol, predisposition to coronary heart disease, or longevity. The relation of a -493G↷T polymorphism in the promoter of MTP to blood pressure was examined in a population-based study. The subjects (1124 men, 1108 women) were aged 40-79 years and were randomly recruited to a population-based prospective cohort study of aging and age-related diseases in Japan. Blood pressure was measured at least twice with subjects in the sitting position. The serum lipid profile was determined after the subjects had fasted overnight. The -493G↷T genotype of MTP was determined with a fluorescence-based allele-specific DNA primer assay system. There was no difference in the serum concentrations of total cholesterol, high density lipoprotein-cholesterol, low density lipoprotein-cholesterol, or triglycerides among MTP genotypes for men or for women. Systolic or diastolic blood pressure was not related to the -493G↷T polymorphism in men. For women, however, systolic and diastolic blood pressures were significantly related to MTP genotype, with the T allele of the polymorphism being associated with low blood pressure. The relation between MTP genotype and the prevalence of hypertension was almost significant (P=0.055) for all women. Although MTP genotype was not associated with the prevalence of hypertension in premenopausal women, the relation between these parameters was significant (P=0.040) in postmenopausal women, with the TT genotype protecting against this condition. These results suggest that MTP genotype is a determinant of blood pressure in Japanese women.

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January 2006
Volume 17 Issue 1

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Yamada Y, Ando F and Shimokata H: Association of a microsomal triglyceride transfer protein gene polymorphism with blood pressure in Japanese women. Int J Mol Med 17: 83-88, 2006
APA
Yamada, Y., Ando, F., & Shimokata, H. (2006). Association of a microsomal triglyceride transfer protein gene polymorphism with blood pressure in Japanese women. International Journal of Molecular Medicine, 17, 83-88. https://doi.org/10.3892/ijmm.17.1.83
MLA
Yamada, Y., Ando, F., Shimokata, H."Association of a microsomal triglyceride transfer protein gene polymorphism with blood pressure in Japanese women". International Journal of Molecular Medicine 17.1 (2006): 83-88.
Chicago
Yamada, Y., Ando, F., Shimokata, H."Association of a microsomal triglyceride transfer protein gene polymorphism with blood pressure in Japanese women". International Journal of Molecular Medicine 17, no. 1 (2006): 83-88. https://doi.org/10.3892/ijmm.17.1.83