Tumour necrosis factor-α: prognostic role and relationship with interleukin-8 and endothelin-1 in non-small cell lung cancer

  • Authors:
    • Laura Boldrini
    • Silvia Gisfredi
    • Silvia Ursino
    • Marco Lucchi
    • Franca Melfi
    • Alfredo Mussi
    • Fulvio Basolo
    • Gabriella Fontanini
  • View Affiliations

  • Published online on: May 1, 2006     https://doi.org/10.3892/ijmm.17.5.887
  • Pages: 887-892
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Abstract

Cytokines mediate numerous physiological and immune reactions, which are manifested in various biological effects, including tumouricidal activity. We evaluated the expression of the pleiotropic cytokine, tumour necrosis factor-α (TNF-α), by competitive PCR technique in 47 non-small cell lung cancer (NSCLC) cases and the impact of TNF-α on their clinical behaviour. Using univariate analysis, our study demonstrated a positive correlation between high TNF-α expression and favourable prognosis in NSCLC in terms of overall survival and disease free interval (p=0.03 and 0.04, respectively) and TNF-α maintained its independent role in multivariate analysis. TNF-α can stimulate the expression of many molecules, including interleukin-8 (IL-8) and endothelin-1 (ET-1); in our study, the expression of TNF-α was significantly associated with high IL-8 mRNA levels (p=0.008) and ET-1 mRNA positivity (p=0.03). We suggested that TNF-α can induce ET-1 mRNA expression in NSCLC, similarly to IL-8 expression. Our study may also contribute to advancing the knowledge of the molecular relationship between cytokines and endothelial functions in NSCLC.

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May 2006
Volume 17 Issue 5

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Boldrini L, Gisfredi S, Ursino S, Lucchi M, Melfi F, Mussi A, Basolo F and Fontanini G: Tumour necrosis factor-α: prognostic role and relationship with interleukin-8 and endothelin-1 in non-small cell lung cancer. Int J Mol Med 17: 887-892, 2006
APA
Boldrini, L., Gisfredi, S., Ursino, S., Lucchi, M., Melfi, F., Mussi, A. ... Fontanini, G. (2006). Tumour necrosis factor-α: prognostic role and relationship with interleukin-8 and endothelin-1 in non-small cell lung cancer. International Journal of Molecular Medicine, 17, 887-892. https://doi.org/10.3892/ijmm.17.5.887
MLA
Boldrini, L., Gisfredi, S., Ursino, S., Lucchi, M., Melfi, F., Mussi, A., Basolo, F., Fontanini, G."Tumour necrosis factor-α: prognostic role and relationship with interleukin-8 and endothelin-1 in non-small cell lung cancer". International Journal of Molecular Medicine 17.5 (2006): 887-892.
Chicago
Boldrini, L., Gisfredi, S., Ursino, S., Lucchi, M., Melfi, F., Mussi, A., Basolo, F., Fontanini, G."Tumour necrosis factor-α: prognostic role and relationship with interleukin-8 and endothelin-1 in non-small cell lung cancer". International Journal of Molecular Medicine 17, no. 5 (2006): 887-892. https://doi.org/10.3892/ijmm.17.5.887