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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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May 2006 Volume 17 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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May 2006 Volume 17 Issue 5

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Article

Amelioration of liver fibrogenesis by dual inhibition of PDGF and TGF-β with a combination of imatinib mesylate and ACE inhibitor in rats

  • Authors:
    • Hitoshi Yoshiji
    • Shigeki Kuriyama
    • Ryuichi Noguchi
    • Yasuhide Ikenaka
    • Junichi Yoshii
    • Koji Yanase
    • Tadashi Namisaki
    • Mitsuteru Kitade
    • Masaharu Yamazaki
    • Kiyoshi Asada
    • Takemi Akahane
    • Tatsuhiro Tsujimoto
    • Masahito Uemura
    • Hiroshi Fukui

  • View Affiliations / Copyright

    Affiliations: Third Department of Internal Medicine, Nara Medical University, Kashihara, Nara 634-8522, Japan. yoshijih@naramed-u.ac.jp
  • Pages: 899-904
    |
    Published online on: May 1, 2006
       https://doi.org/10.3892/ijmm.17.5.899
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Abstract

Both platelet-derived growth factor (PDGF) and transforming growth factor-β (TGF-β) are known to be pivotal cytokines in liver fibrosis development. The aim of our current study was to elucidate the effects of dual inhibition of PDGF and TGF-β by combination of the clinically used imatinib mesylate (STI-571) and perindopril (an ACE-inhibitor; ACE-I), respectively, on ongoing liver fibrosis development in rats. The effects of STI-571 and ACE-I at clinically comparable low doses were examined in a rat model of CCl4-induced liver fibrogenesis. Treatment with both STI-571 and ACE-I inhibited liver fibrogenesis and suppressed activation of hepatic stellate cells (HSCs). Administration of both agents exerted a more potent inhibitory effect than administration of either single agent. Our in vitro study demonstrated that STI-571 and ACE-I suppressed PDGF receptor (PDGFR) phosphorylation and TGF-β expression in activated HSCs, respectively. Dual suppression of PDGF and TGF-β with a combination of clinically comparable low doses of STI-571 and ACE-I exerted a significant inhibitory effect on ongoing liver fibrosis development. Since both agents are widely used in clinical practice, this combination therapy may provide a new strategy against liver fibrosis in the future.

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Copy and paste a formatted citation
Spandidos Publications style
Yoshiji H, Kuriyama S, Noguchi R, Ikenaka Y, Yoshii J, Yanase K, Namisaki T, Kitade M, Yamazaki M, Asada K, Asada K, et al: Amelioration of liver fibrogenesis by dual inhibition of PDGF and TGF-β with a combination of imatinib mesylate and ACE inhibitor in rats. Int J Mol Med 17: 899-904, 2006.
APA
Yoshiji, H., Kuriyama, S., Noguchi, R., Ikenaka, Y., Yoshii, J., Yanase, K. ... Fukui, H. (2006). Amelioration of liver fibrogenesis by dual inhibition of PDGF and TGF-β with a combination of imatinib mesylate and ACE inhibitor in rats. International Journal of Molecular Medicine, 17, 899-904. https://doi.org/10.3892/ijmm.17.5.899
MLA
Yoshiji, H., Kuriyama, S., Noguchi, R., Ikenaka, Y., Yoshii, J., Yanase, K., Namisaki, T., Kitade, M., Yamazaki, M., Asada, K., Akahane, T., Tsujimoto, T., Uemura, M., Fukui, H."Amelioration of liver fibrogenesis by dual inhibition of PDGF and TGF-β with a combination of imatinib mesylate and ACE inhibitor in rats". International Journal of Molecular Medicine 17.5 (2006): 899-904.
Chicago
Yoshiji, H., Kuriyama, S., Noguchi, R., Ikenaka, Y., Yoshii, J., Yanase, K., Namisaki, T., Kitade, M., Yamazaki, M., Asada, K., Akahane, T., Tsujimoto, T., Uemura, M., Fukui, H."Amelioration of liver fibrogenesis by dual inhibition of PDGF and TGF-β with a combination of imatinib mesylate and ACE inhibitor in rats". International Journal of Molecular Medicine 17, no. 5 (2006): 899-904. https://doi.org/10.3892/ijmm.17.5.899
Copy and paste a formatted citation
x
Spandidos Publications style
Yoshiji H, Kuriyama S, Noguchi R, Ikenaka Y, Yoshii J, Yanase K, Namisaki T, Kitade M, Yamazaki M, Asada K, Asada K, et al: Amelioration of liver fibrogenesis by dual inhibition of PDGF and TGF-β with a combination of imatinib mesylate and ACE inhibitor in rats. Int J Mol Med 17: 899-904, 2006.
APA
Yoshiji, H., Kuriyama, S., Noguchi, R., Ikenaka, Y., Yoshii, J., Yanase, K. ... Fukui, H. (2006). Amelioration of liver fibrogenesis by dual inhibition of PDGF and TGF-β with a combination of imatinib mesylate and ACE inhibitor in rats. International Journal of Molecular Medicine, 17, 899-904. https://doi.org/10.3892/ijmm.17.5.899
MLA
Yoshiji, H., Kuriyama, S., Noguchi, R., Ikenaka, Y., Yoshii, J., Yanase, K., Namisaki, T., Kitade, M., Yamazaki, M., Asada, K., Akahane, T., Tsujimoto, T., Uemura, M., Fukui, H."Amelioration of liver fibrogenesis by dual inhibition of PDGF and TGF-β with a combination of imatinib mesylate and ACE inhibitor in rats". International Journal of Molecular Medicine 17.5 (2006): 899-904.
Chicago
Yoshiji, H., Kuriyama, S., Noguchi, R., Ikenaka, Y., Yoshii, J., Yanase, K., Namisaki, T., Kitade, M., Yamazaki, M., Asada, K., Akahane, T., Tsujimoto, T., Uemura, M., Fukui, H."Amelioration of liver fibrogenesis by dual inhibition of PDGF and TGF-β with a combination of imatinib mesylate and ACE inhibitor in rats". International Journal of Molecular Medicine 17, no. 5 (2006): 899-904. https://doi.org/10.3892/ijmm.17.5.899
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