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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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May 2006 Volume 17 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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May 2006 Volume 17 Issue 5

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Article

Abnormal DNA end-joining activity in human head and neck cancer

  • Authors:
    • Ki-Hyuk Shin
    • Mo K. Kang
    • Reuben H. Kim
    • Ayako Kameta
    • Marcel A. Baluda
    • No-Hee Park
  • View Affiliations / Copyright

    Affiliations: UCLA School of Dentistry, Los Angeles, CA 90095-1668, USA
  • Pages: 917-924
    |
    Published online on: May 1, 2006
       https://doi.org/10.3892/ijmm.17.5.917
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Abstract

In human cells, DNA double-strand breaks (DSBs) are repaired primarily by the DNA end-joining (EJ) process and thus, abnormal DNA EJ activities lead to an accumulation of mutations and/or aneuploidy, resulting in genetic instability of cells. Since genetic instability is the hallmark of cancer cells, we studied the DNA EJ activities of normal, non-malignant immortalized and malignant human epithelial cells to investigate the association between DNA EJ and carcinogenesis. We found a significant diminution of precise (error-free) DNA EJ activities in non-malignant immortalized human oral keratinocytes (HOK-16B) and human head and neck squamous cell carcinoma (HNSCC) cells compared to that in normal human oral keratinocytes (NHOK). Moreover, abnormal DNA EJ activities were detected exclusively in HOK-16B and HNSCC cells due to microhomology-mediated and non-microhomology-mediated end-joining activities in these cells. These data indicated that aberrant DNA EJ activity may be partly responsible for genetic instability and oncogenic transformation.

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Copy and paste a formatted citation
Spandidos Publications style
Shin K, Kang MK, Kim RH, Kameta A, Baluda MA and Park N: Abnormal DNA end-joining activity in human head and neck cancer. Int J Mol Med 17: 917-924, 2006.
APA
Shin, K., Kang, M.K., Kim, R.H., Kameta, A., Baluda, M.A., & Park, N. (2006). Abnormal DNA end-joining activity in human head and neck cancer. International Journal of Molecular Medicine, 17, 917-924. https://doi.org/10.3892/ijmm.17.5.917
MLA
Shin, K., Kang, M. K., Kim, R. H., Kameta, A., Baluda, M. A., Park, N."Abnormal DNA end-joining activity in human head and neck cancer". International Journal of Molecular Medicine 17.5 (2006): 917-924.
Chicago
Shin, K., Kang, M. K., Kim, R. H., Kameta, A., Baluda, M. A., Park, N."Abnormal DNA end-joining activity in human head and neck cancer". International Journal of Molecular Medicine 17, no. 5 (2006): 917-924. https://doi.org/10.3892/ijmm.17.5.917
Copy and paste a formatted citation
x
Spandidos Publications style
Shin K, Kang MK, Kim RH, Kameta A, Baluda MA and Park N: Abnormal DNA end-joining activity in human head and neck cancer. Int J Mol Med 17: 917-924, 2006.
APA
Shin, K., Kang, M.K., Kim, R.H., Kameta, A., Baluda, M.A., & Park, N. (2006). Abnormal DNA end-joining activity in human head and neck cancer. International Journal of Molecular Medicine, 17, 917-924. https://doi.org/10.3892/ijmm.17.5.917
MLA
Shin, K., Kang, M. K., Kim, R. H., Kameta, A., Baluda, M. A., Park, N."Abnormal DNA end-joining activity in human head and neck cancer". International Journal of Molecular Medicine 17.5 (2006): 917-924.
Chicago
Shin, K., Kang, M. K., Kim, R. H., Kameta, A., Baluda, M. A., Park, N."Abnormal DNA end-joining activity in human head and neck cancer". International Journal of Molecular Medicine 17, no. 5 (2006): 917-924. https://doi.org/10.3892/ijmm.17.5.917
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