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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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May 2006 Volume 17 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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May 2006 Volume 17 Issue 5

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Article

Ethanol extract from Artemisia vestita, a traditional Tibetan medicine, exerts anti-sepsis action through down-regulating the MAPK and NF-κB pathways

  • Authors:
    • Yang Sun
    • Yi-Hua Li
    • Xing-Xin Wu
    • Wei Zheng
    • Zong-Hui Guo
    • Yang Li
    • Ting Chen
    • Zi-Chun Hua
    • Qiang Xu

  • View Affiliations / Copyright

    Affiliations: State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210093, P.R. China
  • Pages: 957-962
    |
    Published online on: May 1, 2006
       https://doi.org/10.3892/ijmm.17.5.957
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Abstract

Artemisia vestita Wall., a traditional Tibetan medicine, has wide clinical application for inflammatory diseases. However, its molecular mechanism of anti-inflammatory effect is poorly understood. In the present study, we investigated the anti-inflammatory activity and under-lying mechanism of the ethanol extract from Artemisia vestita (AV-ext) on lipopolysaccharide (LPS)-induced sepsis. Pretreatment with AV-ext significantly decreased the levels of tumor necrosis factor-α (TNF-α) in serum and liver and lung tissues, and improved the survival of mice with experimental sepsis. AV-ext also remarkably reduced the expression levels of TNF-α, interleukin-1β and cyclooxygenase-2 in LPS-stimulated RAW 264.7 macrophages and dose dependently suppressed the activation of mitogen-activated protein kinases (MAPKs), such as p38, extracellular signal-regulated kinase (ERK1/2) and c-Jun NH2-terminal kinase (JNK). Furthermore, pretreatment with AV-ext dose dependently inhibited the activation of nuclear factor-κB (NF-κB), as well as the degradation and phosphorylation of inhibitory κB (IκB) in LPS-activated RAW 264.7 macrophages. These results collectively reveal that AV-ext inhibits TNF-α release from macrophages by suppressing MAPK and NF-κB signaling pathways and suggest that AV-ext may be beneficial for the treatment of endotoxin shock or sepsis.

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Copy and paste a formatted citation
Spandidos Publications style
Sun Y, Li Y, Wu X, Zheng W, Guo Z, Li Y, Chen T, Hua Z and Xu Q: Ethanol extract from Artemisia vestita, a traditional Tibetan medicine, exerts anti-sepsis action through down-regulating the MAPK and NF-κB pathways. Int J Mol Med 17: 957-962, 2006.
APA
Sun, Y., Li, Y., Wu, X., Zheng, W., Guo, Z., Li, Y. ... Xu, Q. (2006). Ethanol extract from Artemisia vestita, a traditional Tibetan medicine, exerts anti-sepsis action through down-regulating the MAPK and NF-κB pathways. International Journal of Molecular Medicine, 17, 957-962. https://doi.org/10.3892/ijmm.17.5.957
MLA
Sun, Y., Li, Y., Wu, X., Zheng, W., Guo, Z., Li, Y., Chen, T., Hua, Z., Xu, Q."Ethanol extract from Artemisia vestita, a traditional Tibetan medicine, exerts anti-sepsis action through down-regulating the MAPK and NF-κB pathways". International Journal of Molecular Medicine 17.5 (2006): 957-962.
Chicago
Sun, Y., Li, Y., Wu, X., Zheng, W., Guo, Z., Li, Y., Chen, T., Hua, Z., Xu, Q."Ethanol extract from Artemisia vestita, a traditional Tibetan medicine, exerts anti-sepsis action through down-regulating the MAPK and NF-κB pathways". International Journal of Molecular Medicine 17, no. 5 (2006): 957-962. https://doi.org/10.3892/ijmm.17.5.957
Copy and paste a formatted citation
x
Spandidos Publications style
Sun Y, Li Y, Wu X, Zheng W, Guo Z, Li Y, Chen T, Hua Z and Xu Q: Ethanol extract from Artemisia vestita, a traditional Tibetan medicine, exerts anti-sepsis action through down-regulating the MAPK and NF-κB pathways. Int J Mol Med 17: 957-962, 2006.
APA
Sun, Y., Li, Y., Wu, X., Zheng, W., Guo, Z., Li, Y. ... Xu, Q. (2006). Ethanol extract from Artemisia vestita, a traditional Tibetan medicine, exerts anti-sepsis action through down-regulating the MAPK and NF-κB pathways. International Journal of Molecular Medicine, 17, 957-962. https://doi.org/10.3892/ijmm.17.5.957
MLA
Sun, Y., Li, Y., Wu, X., Zheng, W., Guo, Z., Li, Y., Chen, T., Hua, Z., Xu, Q."Ethanol extract from Artemisia vestita, a traditional Tibetan medicine, exerts anti-sepsis action through down-regulating the MAPK and NF-κB pathways". International Journal of Molecular Medicine 17.5 (2006): 957-962.
Chicago
Sun, Y., Li, Y., Wu, X., Zheng, W., Guo, Z., Li, Y., Chen, T., Hua, Z., Xu, Q."Ethanol extract from Artemisia vestita, a traditional Tibetan medicine, exerts anti-sepsis action through down-regulating the MAPK and NF-κB pathways". International Journal of Molecular Medicine 17, no. 5 (2006): 957-962. https://doi.org/10.3892/ijmm.17.5.957
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