Resveratrol inhibits inducible nitric oxide synthase and cyclooxygenase-2 expression in β-amyloid-treated C6 glioma cells

  • Authors:
    • Young Ae Kim
    • Sun-Young Lim
    • Sook-Hee Rhee
    • Kun Young Park
    • Cheorl-Ho Kim
    • Byung Tae Choi
    • Su Jae Lee
    • Yeong-Min Park
    • Yung Hyun Choi
  • View Affiliations

  • Published online on: June 1, 2006     https://doi.org/10.3892/ijmm.17.6.1069
  • Pages: 1069-1075
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Abstract

Resveratrol has been reported to exert a variety of important pharmacological effects including anti-inflammatory, cardioprotective and cancer chemopreventive properties; however, its mechanisms of action are not completely understood. β-amyloid protein is considered to be responsible for the formation of senile plaques that accumulate in the brains of patients with Alzheimer disease. In the present study, we investigated the protective effect of resveratrol on β-amyloid-induced cytoxicity in cultured rat astroglioma C6 cells. Preincubation of C6 cells with resveratrol concentration-dependently protected the cells from the growth inhibition induced by β-amyloid treatment. β-amyloid treatment led to increased nitric oxide (NO) synthesis and inducible nitric oxide synthase (iNOS) expression; however, cells pretreated with resveratrol showed a dose-dependent inhibition of NO production and iNOS expression following β-amyloid treatment. Resveratrol also attenuated β-amyloid-induced prostaglandin E2 (PGE2) release, which was associated with the inhibition of cyclooxygenase (COX)-2 expression. Furthermore, β-amyloid treatment induced nuclear translocation of NF-κB, which was suppressed by resveratrol pretreatment. Collectively, the present results indicate that modulation of nuclear factor-κB (NF-κB) activity is involved in the neuroprotective action of resveratrol against β-amyloid-induced toxicity.

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June 2006
Volume 17 Issue 6

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Kim YA, Lim S, Rhee S, Park KY, Kim C, Choi BT, Lee SJ, Park Y and Choi YH: Resveratrol inhibits inducible nitric oxide synthase and cyclooxygenase-2 expression in β-amyloid-treated C6 glioma cells. Int J Mol Med 17: 1069-1075, 2006
APA
Kim, Y.A., Lim, S., Rhee, S., Park, K.Y., Kim, C., Choi, B.T. ... Choi, Y.H. (2006). Resveratrol inhibits inducible nitric oxide synthase and cyclooxygenase-2 expression in β-amyloid-treated C6 glioma cells. International Journal of Molecular Medicine, 17, 1069-1075. https://doi.org/10.3892/ijmm.17.6.1069
MLA
Kim, Y. A., Lim, S., Rhee, S., Park, K. Y., Kim, C., Choi, B. T., Lee, S. J., Park, Y., Choi, Y. H."Resveratrol inhibits inducible nitric oxide synthase and cyclooxygenase-2 expression in β-amyloid-treated C6 glioma cells". International Journal of Molecular Medicine 17.6 (2006): 1069-1075.
Chicago
Kim, Y. A., Lim, S., Rhee, S., Park, K. Y., Kim, C., Choi, B. T., Lee, S. J., Park, Y., Choi, Y. H."Resveratrol inhibits inducible nitric oxide synthase and cyclooxygenase-2 expression in β-amyloid-treated C6 glioma cells". International Journal of Molecular Medicine 17, no. 6 (2006): 1069-1075. https://doi.org/10.3892/ijmm.17.6.1069