Adiponectin receptor expression in the human adrenal cortex and aldosterone-producing adenomas

  • Authors:
    • Gian Paolo Rossi
    • Daniele Sticchi
    • Luisa Giuliani
    • Paolo Bernante
    • Silvia Zavattiero
    • Achille C. Pessina
    • Gastone G. Nussdorfer
  • View Affiliations

  • Published online on: June 1, 2006     https://doi.org/10.3892/ijmm.17.6.975
  • Pages: 975-980
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Abstract

Adiponectin is an adipocyte-derived circulating peptide that plays an important role in adipose tissue metabolism, insulin sensitivity and cardiovascular disease. The adrenal gland, by secreting glucorticoid and mineralocorticoid hormones, intervenes in cardiovascular and glucose metabolism regulation and is surrounded by adipose tissue. Hence, we investigated the hypothesis that adiponectin receptor types 1 and 2 (adipo-R1 and adipo-R2) are expressed in the human adrenal gland and in adrenocortical zona glomerulosa cell-derived aldosterone-producing adenoma (APA) tissue. We used real-time reverse transcription-polymerase chain reaction to demonstrate the mRNA of adipo-R1 and adipo-R2 in 10 histologically normal human adrenal cortexes that were obtained from patients with renal cancer undergoing nephrectomy with ipsilateral adrenalectomy and in 10 APAs. Melting curve analysis and sequencing were used to confirm the specificity of the amplicons obtained. Results consistently showed the expression of specific mRNAs of adiponectin receptors in all histologically normal human adrenal cortexes and APAs. This novel finding suggests that adiponectin could play a regulatory role in adrenocortical function and growth in humans.

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June 2006
Volume 17 Issue 6

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Rossi GP, Sticchi D, Giuliani L, Bernante P, Zavattiero S, Pessina AC and Nussdorfer GG: Adiponectin receptor expression in the human adrenal cortex and aldosterone-producing adenomas. Int J Mol Med 17: 975-980, 2006
APA
Rossi, G.P., Sticchi, D., Giuliani, L., Bernante, P., Zavattiero, S., Pessina, A.C., & Nussdorfer, G.G. (2006). Adiponectin receptor expression in the human adrenal cortex and aldosterone-producing adenomas. International Journal of Molecular Medicine, 17, 975-980. https://doi.org/10.3892/ijmm.17.6.975
MLA
Rossi, G. P., Sticchi, D., Giuliani, L., Bernante, P., Zavattiero, S., Pessina, A. C., Nussdorfer, G. G."Adiponectin receptor expression in the human adrenal cortex and aldosterone-producing adenomas". International Journal of Molecular Medicine 17.6 (2006): 975-980.
Chicago
Rossi, G. P., Sticchi, D., Giuliani, L., Bernante, P., Zavattiero, S., Pessina, A. C., Nussdorfer, G. G."Adiponectin receptor expression in the human adrenal cortex and aldosterone-producing adenomas". International Journal of Molecular Medicine 17, no. 6 (2006): 975-980. https://doi.org/10.3892/ijmm.17.6.975