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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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July 2006 Volume 18 Issue 1

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

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Article

Endothelin-1 activates Homer 1α expression via mitogen-activated protein kinase in cardiac myocytes

  • Authors:
    • Takahiro Kawamoto
    • Kiyonori Togi
    • Ryoko Yamauchi
    • Yoshinori Yoshida
    • Yasuhiro Nakashima
    • Toru Kita
    • Makoto Tanaka

  • View Affiliations / Copyright

    Affiliations: Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan
  • Pages: 193-196
    |
    Published online on: July 1, 2006
       https://doi.org/10.3892/ijmm.18.1.193
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Abstract

Homer proteins are a family of scaffolding proteins which may play an important role in calcium signaling by facilitating the assembly of signaling complexes in neuronal cells. Among the three splice variants of Homer 1, Homer 1α is rapidly up-regulated by neural stimulation and may regulate the disassembly of signaling complexes mediated by Homer proteins. In spite of its potential importance in calcium signaling, the regulation of Homer 1α expression in cardiac myocytes has never been investigated. In this study, we examined the regulation of Homer 1α expression in cardiac myocytes. Homer 1α was significantly up-regulated by several hypertrophic agonists, including endothelin-1 (ET-1), phenyl-ephrine, isoprotenerol and angiotensin-II, and ET-1 most strikingly induced Homer 1α expression. The induction of Homer 1α expression by ET-1 peaked at 2 h and inhibitors for mitogen-activated/extracellular signal regulated kinase (MEK) significantly suppressed the induction of Homer 1α. This study first clarified the regulation of Homer 1α expression in cardiac myocytes and demonstrated that ET-1 induced Homer 1α expression through the mitogen-activated protein kinase pathway.

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Copy and paste a formatted citation
Spandidos Publications style
Kawamoto T, Togi K, Yamauchi R, Yoshida Y, Nakashima Y, Kita T and Tanaka M: Endothelin-1 activates Homer 1α expression via mitogen-activated protein kinase in cardiac myocytes. Int J Mol Med 18: 193-196, 2006.
APA
Kawamoto, T., Togi, K., Yamauchi, R., Yoshida, Y., Nakashima, Y., Kita, T., & Tanaka, M. (2006). Endothelin-1 activates Homer 1α expression via mitogen-activated protein kinase in cardiac myocytes. International Journal of Molecular Medicine, 18, 193-196. https://doi.org/10.3892/ijmm.18.1.193
MLA
Kawamoto, T., Togi, K., Yamauchi, R., Yoshida, Y., Nakashima, Y., Kita, T., Tanaka, M."Endothelin-1 activates Homer 1α expression via mitogen-activated protein kinase in cardiac myocytes". International Journal of Molecular Medicine 18.1 (2006): 193-196.
Chicago
Kawamoto, T., Togi, K., Yamauchi, R., Yoshida, Y., Nakashima, Y., Kita, T., Tanaka, M."Endothelin-1 activates Homer 1α expression via mitogen-activated protein kinase in cardiac myocytes". International Journal of Molecular Medicine 18, no. 1 (2006): 193-196. https://doi.org/10.3892/ijmm.18.1.193
Copy and paste a formatted citation
x
Spandidos Publications style
Kawamoto T, Togi K, Yamauchi R, Yoshida Y, Nakashima Y, Kita T and Tanaka M: Endothelin-1 activates Homer 1α expression via mitogen-activated protein kinase in cardiac myocytes. Int J Mol Med 18: 193-196, 2006.
APA
Kawamoto, T., Togi, K., Yamauchi, R., Yoshida, Y., Nakashima, Y., Kita, T., & Tanaka, M. (2006). Endothelin-1 activates Homer 1α expression via mitogen-activated protein kinase in cardiac myocytes. International Journal of Molecular Medicine, 18, 193-196. https://doi.org/10.3892/ijmm.18.1.193
MLA
Kawamoto, T., Togi, K., Yamauchi, R., Yoshida, Y., Nakashima, Y., Kita, T., Tanaka, M."Endothelin-1 activates Homer 1α expression via mitogen-activated protein kinase in cardiac myocytes". International Journal of Molecular Medicine 18.1 (2006): 193-196.
Chicago
Kawamoto, T., Togi, K., Yamauchi, R., Yoshida, Y., Nakashima, Y., Kita, T., Tanaka, M."Endothelin-1 activates Homer 1α expression via mitogen-activated protein kinase in cardiac myocytes". International Journal of Molecular Medicine 18, no. 1 (2006): 193-196. https://doi.org/10.3892/ijmm.18.1.193
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