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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
July 2006 Volume 18 Issue 1

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Article

HIV-1 infection: Is it time to reconsider our concepts?

Elias Krambovitis, Demetrios A. Spandidos
Pages: 3-8
Published online on: 01 July 2006

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Article

Specific subtelomere loss on chromosome der(11)t(3;11)(q23;q23)×2 in anaplastic thyroid cancer cell line OCUT-1

Makoto Kammori, Naoyoshi Onoda, Ken-Ichi Nakamura, Naotaka Izumiyama, Kana Ogisawa, Rie Kurabayashi, Toshihisa Ogawa, Michio Kaminishi, Steven S.S. Poon, Kaiyo Takubo
Pages: 9-16
Published online on: 01 July 2006

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Article

Comano's (Trentino) thermal water interferes with the expression and secretion of vascular endothelial growth factor-A protein isoforms by cultured human psoriatic keratinocytes: A potential mechanism of its anti-psoriatic action

Anna Chiarini, Ilaria Dal Pra, Raffaella Pacchiana, Lia Menapace, Giuseppe Zumiani, Mauro Zanoni, Ubaldo Armato
Pages: 17-25
Published online on: 01 July 2006

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Article

Mutational analysis of the NF2 gene in sporadic meningiomas by denaturing high-performance liquid chromatography

Jae-Hong Kim, In-Soo Kim, Sun-Young Kwon, Byeong-Churl Jang, Seong-Il Suh, Dong-Hoon Shin, Chang-Ho Jeon, Eun-Ik Son, Sang-Pyo Kim
Pages: 27-32
Published online on: 01 July 2006

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Article

PAR-1 upregulation by trimethyltin and lipopolysaccharide in cultured rat astrocytes

Elena Pompili, Cinzia Fabrizi, Lorenzo Fumagalli
Pages: 33-39
Published online on: 01 July 2006

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Article

COX-2 inhibitors sensitize human hepatocellular carcinoma cells to TRAIL-induced apoptosis

Yutaka Yamanaka, Katsuya Shiraki, Tomoko Inoue, Kazumi Miyashita, Hiroyuki Fuke, Yumi Yamaguchi, Norihiko Yamamoto, Keiichi Ito, Kazushi Sugimoto, Takeshi Nakano
Pages: 41-47
Published online on: 01 July 2006

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Article

Neurotrophins and neurotransmitters in human palatine tonsils: An immunohistochemical and RT-PCR analysis

Elena Bronzetti, Marco Artico, Elena Pompili, Laura M. Felici, Annarita Stringaro, Sandro Bosco, Giuseppe Magliulo, Marisa Colone, Giuseppe Arancia, Marco Vitale, Lorenzo Fumagalli
Pages: 49-58
Published online on: 01 July 2006

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Article

Heterozygous Thr 135 Ala polymorphism at leucine-rich repeat (LRR) in genomic DNA of toll-like receptor 4 in patients with poorly-differentiated gastric adenocarcinomas

Tadashi Ohara, Tetsuo Morishita, Hidekazu Suzuki, Toshifumi Hibi
Pages: 59-63
Published online on: 01 July 2006

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Article

Role of the carbohydrate recognition domains of mouse galectin-4 in oligosaccharide binding and epitope recognition and expression of galectin-4 and galectin-6 in mouse cells and tissues

Vladimíra Marková, Karel Smetana, Gabriela Jeníková, Jitka Láchová, Veronika Krejciríková, Martin Poplstein, Milan Fábry, Jirí Brynda, Richard A. Alvarez, Richard D. Cummings, Petr Maly
Pages: 65-76
Published online on: 01 July 2006

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Article

Cellular apoptosis susceptibility protein and proliferation in human hepatocellular carcinoma

Katsuya Shiraki, Katsuhiko Fujikawa, Kazushi Sugimoto, Takeshi Ito, Takenari Yamanaka, Masahiro Suzuki, Kentaro Yoneda, Koujiro Takase, Takeshi Nakano
Pages: 77-81
Published online on: 01 July 2006

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Article

Dynamics of hyaluronan, CD44, and inflammatory cells in the rat kidney after ischemia/reperfusion injury

Anne-Emilie Declèves, Nathalie Caron, Denis Nonclercq, Alexandre Legrand, Gérard Toubeau, Ronald Kramp, Bruno Flamion
Pages: 83-94
Published online on: 01 July 2006

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Article

Regulation of calmodulin-stimulated cyclic nucleotide phosphodiesterase (PDE1): Review

Rajendra K. Sharma, Shankar B. Das, Ashakumary Lakshmikuttyamma, Ponniah Selvakumar, Anuraag Shrivastav
Pages: 95-105
Published online on: 01 July 2006

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Article

Measurement of the radical scavenging activity of chicken jelly soup, a part of the medicated diet, ‘Yakuzen’, made from gelatin gel food ‘Nikogori’, using chemiluminescence and electron spin resonance methods

Norie Nagatsuka, Kazuki Harada, Mami Ando, Keigo Nagao
Pages: 107-111
Published online on: 01 July 2006

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Article

Resistance to endoplasmic reticulum stress is an acquired cellular characteristic of rheumatoid synovial cells

Satoshi Yamasaki, Naoko Yagishita, Kaneyuki Tsuchimochi, Yukihiro Kato, Takeshi Sasaki, Tetsuya Amano, Moroe Beppu, Haruhito Aoki, Hiroshi Nakamura, Kusuki Nishioka, Toshihiro Nakajima
Pages: 113-117
Published online on: 01 July 2006

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Article

Association of polymorphisms in forkhead box C2 and perilipin genes with bone mineral density in community-dwelling Japanese individuals

Yoshiji Yamada, Fujiko Ando, Hiroshi Shimokata
Pages: 119-127
Published online on: 01 July 2006

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Article

Insulin-like growth factor I differentially regulates the expression of HIRF1/hCAF1 and BTG1 genes in human MCF-7 breast cancer cells

Jaydutt V. Vadgama, Zorica Scuric, Rita Chakrabarti, Ehrnad Marzo, Dejun Shen, Yanyuan Wu
Pages: 129-139
Published online on: 01 July 2006

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Article

Metallic but not ceramic wear particles increase prostaglandin E2 release and interleukin-1β gene expression in human blood monocytes in vitro

Marco Galli, Caterina Toriani Terenzi, Gianluca Falcone, Ubaldo Pozzetto, Giuseppe Tringali, Vincenzo De Santis, Mauro Vairano, Pierluigi Navarra, Giacomo Pozzoli
Pages: 141-145
Published online on: 01 July 2006

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Article

Fucoxanthin and its metabolite, fucoxanthinol, suppress adipocyte differentiation in 3T3-L1 cells

Hayato Maeda, Masashi Hosokawa, Tokutake Sashima, Nobuyuki Takahashi, Teruo Kawada, Kazuo Miyashita
Pages: 147-152
Published online on: 01 July 2006

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Article

Expression pattern of matrix metalloproteinase and TIMP genes in fibroblasts derived from Ets-1 knock-out mice compared to wild-type mouse fibroblasts

Jens Claus Hahne, Tanja Fuchs, El Mustapha Haddouti, Ali Fuat Okuducu, Jean Christophe Bories, Nicolas Wernert
Pages: 153-159
Published online on: 01 July 2006

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Article

Activation of the ribosomal protein L13 gene in human gastrointestinal cancer

Toshihisa Kobayashi, Yasushi Sasaki, Yuichiro Oshima, Hiroyuki Yamamoto, Hiroaki Mita, Hiromu Suzuki, Minoru Toyota, Takashi Tokino, Fumio Itoh, Kohzoh Imai, Yasuhisa Shinomura
Pages: 161-170
Published online on: 01 July 2006

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Article

Regucalcin increases Ca2+-ATPase activity in the heart mitochondria of normal and regucalcin transgenic rats

Tania Akhter, Natsumi Sawada, Masayoshi Yamaguchi
Pages: 171-176
Published online on: 01 July 2006

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Article

Mitochondria from the left heart ventricles of both normotensive and spontaneously hypertensive rats oxidize externally added NADH mostly via a novel malate/oxaloacetate shuttle as reconstructed in vitro

Anna Atlante, Teresa M. Seccia, Lidia de Bari, Ersilia Marra, Salvatore Passarella
Pages: 177-186
Published online on: 01 July 2006

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Article

FK506 induces biphasic Ca2+ release from microsomal vesicles of rat pancreatic acinar cells

Terutaka Ozawa
Pages: 187-191
Published online on: 01 July 2006

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Article

Endothelin-1 activates Homer 1α expression via mitogen-activated protein kinase in cardiac myocytes

Takahiro Kawamoto, Kiyonori Togi, Ryoko Yamauchi, Yoshinori Yoshida, Yasuhiro Nakashima, Toru Kita, Makoto Tanaka
Pages: 193-196
Published online on: 01 July 2006

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Article

Effects of some endocrine disruptors on the secretory and proliferative activity of the regenerating rat adrenal cortex

Ludwik K. Malendowicz, Marcin Trejter, Piera Rebuffat, Agnieska Ziolkowska, Gastone G. Nussdorfer, Mariola Majchrzak
Pages: 197-200
Published online on: 01 July 2006

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Article

Inhibition of cell cycle progression via p27Kip1 upregulation and apoptosis induction by an ethanol extract of Rhus verniciflua Stokes in AGS gastric cancer cells

Ji Hye Kim, Hwang-Phill Kim, Chang-Hwa Jung, Myung Hee Hong, Mu-Chang Hong, Hyun-Su Bae, Sun-Dong Lee, Seon-Yeong Park, Jong-Hyeong Park, Seong-Gyu Ko
Pages: 201-208
Published online on: 01 July 2006

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Article

Oxidized-HDL3 modulates the expression of Cox-2 in human endothelial cells

Elisa Callegari, Giuseppe D. Norata, Hiroyasu Inoue, Alberico L. Catapano
Pages: 209-213
Published online on: 01 July 2006

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Article

Tight junctions and compression therapy in chronic venous insufficiency

Yared Herouy, Birgit Kahle, Marco Idzko, Ingo Eberth, Johannes Norgauer, Felizitas Pannier, Eberhard Rabe, Michael Jünger, Leena Bruckner-Tuderman
Pages: 215-219
Published online on: 01 July 2006

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Journal Cover
February-2026 Volume 57 Issue 2

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

miR‑205: A dual regulator of angiogenesis in health and disease (Review)

Maria Oltra, Miriam Martínez‑Santos, Maria Ybarra, Maria Pires, Chiara Ceresoni, Clara Gomis‑Coloma, Cristina Medina‑Trillo, Javier Sancho, Jorge Barcia
Article Number: 51
Published online on: 29 December 2025

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Astragaloside IV: A multipotent phytochemical for treating fibrotic diseases (Review)

Mingyu Wu, Ke Li, Jiabin Wu, Qiuyu Zhang, Xiaotong Ma, Wei Dai, Haoyang Gao, Xianyi Ding, Wenhong Wang, Weihua Xiao
Article Number: 50
Published online on: 24 December 2025

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Activating transcription factors: Orchestrators of macrophage biology in pathological settings (Review)

Yue-Chen Liu, Jia-Wei Zhao, Xiong-Tao Yue, Qi-Jie Chen, Shan-Jie Rong, Shi-Wei Liu, Fei Sun, Chun-Liang Yang, Cong-Yi Wang
Article Number: 49
Published online on: 24 December 2025

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Role of SIRT3 in digestive system diseases and therapeutic prospects (Review)

Jiajia Li, Qian Liu, Shun Yao, Xin Li, Li Zhang, Yongfeng Wang, Guorong Wen, Jiaxing An, Hai Jin, Biguang Tuo
Article Number: 48
Published online on: 22 December 2025

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Recombinant ADAMTS‑1 promotes muscle regeneration accompanied by downregulation of Notch signaling

Jin-Hwa Kim, Sang-Hyup Lee, Sang-Yoon Kim, Jeong-Won Kim, Ji-Soo Jeong, Eun-Hye Chung, Su-Ha Lee, Chang-Yeop Kim, Bong-Keun Choi, Je-Won Ko, Tae-Won Kim
Article Number: 47
Published online on: 22 December 2025

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A comprehensive review on pain: Model, target, therapy, and prospect (Review)

Chenyu Chang, Xutao Wu, Kejia Liu, Lei Wang, Mozili Adu, Qingyuan Lin, Huilian Huang, Qinge Ma, Rongrui Wei, Xiaoyun Wang, Wenmin Liu
Article Number: 46
Published online on: 17 December 2025

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Retraction Open Access

[Retracted] Curculigoside attenuates myocardial ischemia‑reperfusion injury by inhibiting the opening of the mitochondrial permeability transition pore

Yanbing Zhao, Yuxuan Guo, Yuqiong Chen, Shuang Liu, Nan Wu, Dalin Jia
Article Number: 45
Published online on: 15 December 2025

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Nanomaterials and exercise interventions: A synergistic approach for atherosclerosis therapy (Review)

Quanquan Zhou, Ge‑Lin Zhang, Weitong Sun, Jiayi Cai, Li-Hua Yu
Article Number: 44
Published online on: 10 December 2025

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Selective autophagic degradation of glycolytic activator PFKFB3 contributes to maintaining intestinal epithelial barrier in inflammatory bowel disease

Yiyang Pan, Feng Yang, Liucan Wang, Tianshu Yang, Guangsheng Du, Cong Xu, Hua Yang, Min Yu, Weidong Xiao
Article Number: 43
Published online on: 10 December 2025

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Lactylation‑mediated ferroptosis: A novel mechanism and therapeutic prospects in human diseases (Review)

Zhengjun Lin, Yugang Zou, Songzhu Zou, Kunming Wen
Article Number: 42
Published online on: 08 December 2025

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Dual role of lactate in ferroptosis: Mechanisms, pathophysiology and therapeutic opportunities (Review)

Qian Yu, Yu Kuang, Jie He, Li Yang, Xinjie Li, Hao Yu
Article Number: 41
Published online on: 08 December 2025

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Retraction Open Access

[Retracted] MicroRNA‑493‑5p promotes apoptosis and suppresses proliferation and invasion in liver cancer cells by targeting VAMP2

Guannan Wang, Xiaosan Fang, Meng Han, Xiaoming Wang, Qiang Huang
Article Number: 40
Published online on: 08 December 2025

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Article Open Access

FGF4 alleviates the lung cell damage caused by high glucose via AMPK‑PGC‑1 signaling axis in vitro and in vivo

Qiujuan Fu, Yongfang Ou, Qin Wu, Jue Gong, Feixia Li, Tuxing Wang, Zhitai Lin, Kejie Huang, Jianlong Xie
Article Number: 39
Published online on: 05 December 2025

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STOML2 interacts with PHB to activate the MEK/ERK signaling pathway and mediates autophagy‑related proteins in the progression of hepatocellular carcinoma

Haoyang Hu, Haozhe Zhang, Shuai Han, Jianli Chen, Ying Xie
Article Number: 38
Published online on: 04 December 2025

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HMGB1 mediates low-dose ionizing radiation-induced Wnt/β-catenin activation in SRA01/04 cells: Mechanistic clues to early cataractogenesis

Ping Wang, Chunnan Piao, Dong Yan, Yingxue He, Yaru Li, Li Fan, Mei Tian
Article Number: 37
Published online on: 04 December 2025

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FBXO22 promotes hepatocellular carcinoma progression via paracrine myo‑inositol‑induced M2‑type polarization of macrophages

Liangliang Bai, Jing Xiong, Sihai Chen, Jiahao Hu, Meixia Zhang, Bimin Li, Jing Hu, Mingyan He
Article Number: 36
Published online on: 02 December 2025

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Branched‑chain amino acid metabolism and bone metabolism: Implications for osteoporosis pathogenesis and therapeutic strategies (Review)

Qi Xiao, Haimin Zeng, Ruhui Yang, Yuxin Zhan, Fangzhen Lin, Bofan Chen, Xiang Chen
Article Number: 35
Published online on: 02 December 2025

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Mitochondria-associated endoplasmic reticulum membranes: Emerging regulators of cardiac microvascular ischemia/reperfusion injury (Review)

Yan Wang, Baowei Feng, Yanting Wu, Zongle Sun, Hao Yuan, Wei Chen, Chang Zhao, Zhi Liu
Article Number: 34
Published online on: 02 December 2025

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Role of matrix metalloproteinases in the invasion of glioblastoma and drug interventions (Review)

Bohao Zheng, Ying Han, Haiying Zhang
Article Number: 33
Published online on: 01 December 2025

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Review

Bridging bench to bedside: Exosome‑based strategies for endometriosis diagnosis and treatment (Review)

Wanmeng Chen, Yujiu Ma, Xudong Zhang, Siwen Zhang, Shanshan Wu, Yimeng Lu, Jichun Tan
Article Number: 32
Published online on: 01 December 2025

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Retraction Open Access

[Retracted] miR‑381 functions as a tumor suppressor by targeting ETS1 in pancreatic cancer

Guanen Qiao, Jing Li, Jun Wang, Zhaoyang Wang, Wei Bian
Article Number: 31
Published online on: 01 December 2025

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Journal Cover
March-2026 Volume 57 Issue 3

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Retraction Open Access

[Retracted] Mechanism of cell death induced by silica nanoparticles in hepatocyte cells is by apoptosis

Ye Yang, Xinjing Du, Qiang Wang, Jianwei Liu, Enguo Zhang, Linlin Sai, Cheng Peng, Martin F. Lavin, Abrey Jie Yeo, Xu Yang, Hua Shao, Zhongjun Du
Article Number: 59
Published online on: 12 January 2026

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ZG16B: A key regulator of tumor progression and immune microenvironment modulation in cancer (Review)

Xing-Ming Chen, Yu-Bo Liang, Jin-Xiang Zuo, Zi-Sheng Yang, Le-Yu Zhang, Xin-Yu Zhang, Ping Wan, Yang Ke
Article Number: 58
Published online on: 09 January 2026

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Retraction Open Access

[Retracted] Silica nanoparticles induce cardiomyocyte apoptosis via the mitochondrial pathway in rats following intratracheal instillation

Zhongjun Du, Shangya Chen, Guanqun Cui, Ye Yang, Enguo Zhang, Qiang Wang, Martin F. Lavin, Abrey J. Yeo, Cunxiang Bo, Yu Zhang, Chao Li, Xiaoshan Liu, Xu Yang, Cheng Peng, Hua Shao
Article Number: 57
Published online on: 05 January 2026

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Role of cuproptosis in digestive system tumors (Review)

Li Zhang, Yongpeng Cheng, Lulu Tang, Jiaxing Zhu, Biguang Tuo
Article Number: 56
Published online on: 02 January 2026

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Environmental exposure to air pollution and climate: Intersecting the impact on ear and nose health and chemosensory function (Review)

Yu-Chen Zhang, Lei Zhang, Ping-Ting Zhou, Zi-Hui Xie, Wen-Jie Zhang, Min Fan, Yan-Xun Han, Ye-Hai Liu, Yu-Chen Liu
Article Number: 55
Published online on: 31 December 2025

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Role and mechanisms of ferroptosis in cognitive impairment: From molecular pathways to therapeutic targets (Review)

Shenghui Ge, Deyue Kong, Shuyue Fan, Yi Luo, Xiao Yin, Zehua Jin, Wenqing Xia, Jianhua Ma
Article Number: 54
Published online on: 30 December 2025

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The GPR124‑Wnt‑PPARγ regulatory axis: Molecular mechanisms and therapeutic implications in chronic inflammatory diseases (Review)

Ming-Wang Cui, Si-Yu Tao, Tao Wen, Zhu-Ling Guo
Article Number: 53
Published online on: 30 December 2025

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Review Open Access

Advances in RPGR gene therapy for X‑linked retinitis pigmentosa: From preclinical insights to clinical application (Review)

Yushan Long, Jia Qi, Wenliang Zhang, Huan Qin, Kai Yao
Article Number: 52
Published online on: 30 December 2025

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