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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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July 2006 Volume 18 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July 2006 Volume 18 Issue 1

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Article

Oxidized-HDL3 modulates the expression of Cox-2 in human endothelial cells

  • Authors:
    • Elisa Callegari
    • Giuseppe D. Norata
    • Hiroyasu Inoue
    • Alberico L. Catapano
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacological Sciences, University of Milan, Milan, Italy
  • Pages: 209-213
    |
    Published online on: July 1, 2006
       https://doi.org/10.3892/ijmm.18.1.209
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Abstract

Modified high density lipoprotein (HDL) has been suggested to modulate endothelial expression of pro-inflammatory genes. Since oxidised HDL (Ox-HDL) has been found in atheromatous plaques and receptors for modified HDL are present on endothelial cells, we investigated the effect of Ox-HDL3 on the expression of Cox-1 or Cox-2. Ox-HDL3, increased Cox-2 mRNA and protein expression in endothelial cells while no effect on Cox-1 expression was observed. The intracellular pathways involved in this effect were investigated. The incubation with specific inhibitors of intracellular kinases showed that PI3K is mainly involved in the Ox-HDL3-dependent Cox-2 induction. Transient transfection experiments suggested that the NF-IL6 response element in the proximal promoter (-327 to 59) is involved in Ox-HDL3-mediated Cox-2 expression. These data suggest that Ox-HDL induce Cox-2 expression in endothelial cells through a PI3K/NF-IL6-dependent pathway.

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Copy and paste a formatted citation
Spandidos Publications style
Callegari E, Norata GD, Inoue H and Catapano AL: Oxidized-HDL3 modulates the expression of Cox-2 in human endothelial cells. Int J Mol Med 18: 209-213, 2006.
APA
Callegari, E., Norata, G.D., Inoue, H., & Catapano, A.L. (2006). Oxidized-HDL3 modulates the expression of Cox-2 in human endothelial cells. International Journal of Molecular Medicine, 18, 209-213. https://doi.org/10.3892/ijmm.18.1.209
MLA
Callegari, E., Norata, G. D., Inoue, H., Catapano, A. L."Oxidized-HDL3 modulates the expression of Cox-2 in human endothelial cells". International Journal of Molecular Medicine 18.1 (2006): 209-213.
Chicago
Callegari, E., Norata, G. D., Inoue, H., Catapano, A. L."Oxidized-HDL3 modulates the expression of Cox-2 in human endothelial cells". International Journal of Molecular Medicine 18, no. 1 (2006): 209-213. https://doi.org/10.3892/ijmm.18.1.209
Copy and paste a formatted citation
x
Spandidos Publications style
Callegari E, Norata GD, Inoue H and Catapano AL: Oxidized-HDL3 modulates the expression of Cox-2 in human endothelial cells. Int J Mol Med 18: 209-213, 2006.
APA
Callegari, E., Norata, G.D., Inoue, H., & Catapano, A.L. (2006). Oxidized-HDL3 modulates the expression of Cox-2 in human endothelial cells. International Journal of Molecular Medicine, 18, 209-213. https://doi.org/10.3892/ijmm.18.1.209
MLA
Callegari, E., Norata, G. D., Inoue, H., Catapano, A. L."Oxidized-HDL3 modulates the expression of Cox-2 in human endothelial cells". International Journal of Molecular Medicine 18.1 (2006): 209-213.
Chicago
Callegari, E., Norata, G. D., Inoue, H., Catapano, A. L."Oxidized-HDL3 modulates the expression of Cox-2 in human endothelial cells". International Journal of Molecular Medicine 18, no. 1 (2006): 209-213. https://doi.org/10.3892/ijmm.18.1.209
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