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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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August 2006 Volume 18 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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August 2006 Volume 18 Issue 2

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Article

CD45-positive cells of haematopoietic origin enhance chondrogenic marker gene expression in rat marrow stromal cells

  • Authors:
    • Nazish Ahmed
    • Breda Vogel
    • Eva Rohde
    • Dirk Strunk
    • Joachim Grifka
    • Michaela B. Schulz
    • Susanne Grässel

  • View Affiliations / Copyright

    Affiliations: Experimental Orthopaedics, Department of Orthopaedics, University of Regensburg, 93077 Bad Abbach, Germany
  • Pages: 233-240
    |
    Published online on: August 1, 2006
       https://doi.org/10.3892/ijmm.18.2.233
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Abstract

Adult mesenchymal stem cells (MSCs) can be readily isolated from bone marrow, expanded in culture and subsequently subjected to differentiation into various connective tissue lineages. In general, for animal studies separation of MSCs from other bone marrow-derived cells is achieved by sole adherence to plastic surface of tissue culture flasks; however, this procedure produces a heterogeneous cell population containing CD45-positive haematopoietic cells (HCs) and haematopoietic stem cells (HSCs). It is known, that mixed cell cultures consisting of cocultures of differentiated somatic cells with adult stem cells promote differentiation towards specific cell lineages. For determining the effect of the CD45-positive cell population on the differentiation potential of MSCs, we sorted out the bone marrow-derived adherent cells by immunomagnetic technique (MACS™) to attain a subpopulation of CD45-depleted cells. Herein, we show that the presence of adherent CD45-positive HCs not only promote expression of the chondrogenic marker genes Col2a1, COMP and Sox9, but also of Col1a1, Col10a1 and to a certain degree Cbfa1 in MSCs when cultured in an appropriate three-dimensional environment. These observations constitute a step towards unravelling the influence of haematopoietic cells on chondrogenic differentiation of MSCs.

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Copy and paste a formatted citation
Spandidos Publications style
Ahmed N, Vogel B, Rohde E, Strunk D, Grifka J, Schulz MB and Grässel S: CD45-positive cells of haematopoietic origin enhance chondrogenic marker gene expression in rat marrow stromal cells. Int J Mol Med 18: 233-240, 2006.
APA
Ahmed, N., Vogel, B., Rohde, E., Strunk, D., Grifka, J., Schulz, M.B., & Grässel, S. (2006). CD45-positive cells of haematopoietic origin enhance chondrogenic marker gene expression in rat marrow stromal cells. International Journal of Molecular Medicine, 18, 233-240. https://doi.org/10.3892/ijmm.18.2.233
MLA
Ahmed, N., Vogel, B., Rohde, E., Strunk, D., Grifka, J., Schulz, M. B., Grässel, S."CD45-positive cells of haematopoietic origin enhance chondrogenic marker gene expression in rat marrow stromal cells". International Journal of Molecular Medicine 18.2 (2006): 233-240.
Chicago
Ahmed, N., Vogel, B., Rohde, E., Strunk, D., Grifka, J., Schulz, M. B., Grässel, S."CD45-positive cells of haematopoietic origin enhance chondrogenic marker gene expression in rat marrow stromal cells". International Journal of Molecular Medicine 18, no. 2 (2006): 233-240. https://doi.org/10.3892/ijmm.18.2.233
Copy and paste a formatted citation
x
Spandidos Publications style
Ahmed N, Vogel B, Rohde E, Strunk D, Grifka J, Schulz MB and Grässel S: CD45-positive cells of haematopoietic origin enhance chondrogenic marker gene expression in rat marrow stromal cells. Int J Mol Med 18: 233-240, 2006.
APA
Ahmed, N., Vogel, B., Rohde, E., Strunk, D., Grifka, J., Schulz, M.B., & Grässel, S. (2006). CD45-positive cells of haematopoietic origin enhance chondrogenic marker gene expression in rat marrow stromal cells. International Journal of Molecular Medicine, 18, 233-240. https://doi.org/10.3892/ijmm.18.2.233
MLA
Ahmed, N., Vogel, B., Rohde, E., Strunk, D., Grifka, J., Schulz, M. B., Grässel, S."CD45-positive cells of haematopoietic origin enhance chondrogenic marker gene expression in rat marrow stromal cells". International Journal of Molecular Medicine 18.2 (2006): 233-240.
Chicago
Ahmed, N., Vogel, B., Rohde, E., Strunk, D., Grifka, J., Schulz, M. B., Grässel, S."CD45-positive cells of haematopoietic origin enhance chondrogenic marker gene expression in rat marrow stromal cells". International Journal of Molecular Medicine 18, no. 2 (2006): 233-240. https://doi.org/10.3892/ijmm.18.2.233
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