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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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October 2006 Volume 18 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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Article

Protection of aortic endothelial function in both normal and diabetic rats by intravenous bolus injection of a medium-chain triglyceride: fish oil emulsion

  • Authors:
    • David Fontaine
    • Anne Otto
    • Laurence Portois
    • Jeanine Fontaine
    • Guy Berkenboom
    • Willy J. Malaisse
    • Yvon A. Carpentier

  • View Affiliations / Copyright

    Affiliations: Laboratory of Physiology and Pharmacology, Brussels Free University, B-1070 Brussels, Belgium
  • Pages: 697-704
    |
    Published online on: October 1, 2006
       https://doi.org/10.3892/ijmm.18.4.697
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Abstract

The bolus intravenous injection of a novel medium-chain triglyceride:fish oil emulsion (MCT:FO) was recently proposed as a tool to provoke a rapid and sustained increase of cell phospholipid content in long-chain polyunsaturated ω3 fatty acids, for instance in selected subjects prior to anesthesia and surgery. In this study, therefore, the possible protective effect of MCT:FO upon aortic endothelial function was investigated in both normal and diabetic rats. The animals were injected intravenously 20 h before sacrifice with 1.0 ml of either saline, MCT:FO or a control medium-chain triglyceride:long-chain triglyceride emulsion. The vasomotor response of isolated aortic rings was then explored by assessing the relaxation provoked by increasing concentrations of acetylcholine in rings contracted with phenylephrine. Such measurements were performed before and after exposure of the aortic rings to suitable concentrations of oxidized LDL. In both normal and diabetic rats, the prior injection of the MCT:FO emulsion protected the aortic rings against the deleterious effect of oxidized LDL. In the diabetic rats, a beneficial effect of the MCT:FO emulsion was even observed prior to exposure of the aortic rings to oxidized LDL. These findings support the view that this novel procedure is indeed appropriate to protect endothelial function against oxidative stress.

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Copy and paste a formatted citation
Spandidos Publications style
Fontaine D, Otto A, Portois L, Fontaine J, Berkenboom G, Malaisse WJ and Carpentier YA: Protection of aortic endothelial function in both normal and diabetic rats by intravenous bolus injection of a medium-chain triglyceride: fish oil emulsion. Int J Mol Med 18: 697-704, 2006.
APA
Fontaine, D., Otto, A., Portois, L., Fontaine, J., Berkenboom, G., Malaisse, W.J., & Carpentier, Y.A. (2006). Protection of aortic endothelial function in both normal and diabetic rats by intravenous bolus injection of a medium-chain triglyceride: fish oil emulsion. International Journal of Molecular Medicine, 18, 697-704. https://doi.org/10.3892/ijmm.18.4.697
MLA
Fontaine, D., Otto, A., Portois, L., Fontaine, J., Berkenboom, G., Malaisse, W. J., Carpentier, Y. A."Protection of aortic endothelial function in both normal and diabetic rats by intravenous bolus injection of a medium-chain triglyceride: fish oil emulsion". International Journal of Molecular Medicine 18.4 (2006): 697-704.
Chicago
Fontaine, D., Otto, A., Portois, L., Fontaine, J., Berkenboom, G., Malaisse, W. J., Carpentier, Y. A."Protection of aortic endothelial function in both normal and diabetic rats by intravenous bolus injection of a medium-chain triglyceride: fish oil emulsion". International Journal of Molecular Medicine 18, no. 4 (2006): 697-704. https://doi.org/10.3892/ijmm.18.4.697
Copy and paste a formatted citation
x
Spandidos Publications style
Fontaine D, Otto A, Portois L, Fontaine J, Berkenboom G, Malaisse WJ and Carpentier YA: Protection of aortic endothelial function in both normal and diabetic rats by intravenous bolus injection of a medium-chain triglyceride: fish oil emulsion. Int J Mol Med 18: 697-704, 2006.
APA
Fontaine, D., Otto, A., Portois, L., Fontaine, J., Berkenboom, G., Malaisse, W.J., & Carpentier, Y.A. (2006). Protection of aortic endothelial function in both normal and diabetic rats by intravenous bolus injection of a medium-chain triglyceride: fish oil emulsion. International Journal of Molecular Medicine, 18, 697-704. https://doi.org/10.3892/ijmm.18.4.697
MLA
Fontaine, D., Otto, A., Portois, L., Fontaine, J., Berkenboom, G., Malaisse, W. J., Carpentier, Y. A."Protection of aortic endothelial function in both normal and diabetic rats by intravenous bolus injection of a medium-chain triglyceride: fish oil emulsion". International Journal of Molecular Medicine 18.4 (2006): 697-704.
Chicago
Fontaine, D., Otto, A., Portois, L., Fontaine, J., Berkenboom, G., Malaisse, W. J., Carpentier, Y. A."Protection of aortic endothelial function in both normal and diabetic rats by intravenous bolus injection of a medium-chain triglyceride: fish oil emulsion". International Journal of Molecular Medicine 18, no. 4 (2006): 697-704. https://doi.org/10.3892/ijmm.18.4.697
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