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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
October 2006 Volume 18 Issue 4

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Article

Gene silencing of human RAMP2 mediated by short-interfering RNA

Giovanna Albertin, Maristella Ruggero, Diego Guidolin, Gastone G. Nussdorfer
Pages: 531-535
Published online on: 01 October 2006

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Article

Highly liver-specific heme oxygenase-1 induction by interleukin-11 prevents carbon tetrachloride-induced hepatotoxicity

Tomoko Kawakami, Toru Takahashi, Hiroko Shimizu, Kiichi Nakahira, Mamoru Takeuchi, Hiroshi Katayama, Masataka Yokoyama, Kiyoshi Morita, Reiko Akagi, Shigeru Sassa
Pages: 537-546
Published online on: 01 October 2006

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Article

Promoter hypermethylation of the 14-3-3 σ, SYK and CAGE-1 genes is related to the various phenotypes of urinary bladder carcinomas and associated with progression of transitional cell carcinomas

Ekkehard Kunze, Maike Wendt, Thilo Schlott
Pages: 547-557
Published online on: 01 October 2006

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Article

CD40 expression in HCV-associated chronic liver diseases

Katsuya Shiraki, Kazushi Sugimoto, Hiroshi Okano, Hidetaka Wagayama, Katsuhiko Fujikawa, Takenari Yamanaka, Takeshi Ito, Shigeru Ohmori, Takahisa Sakai, Koujiro Takase, Takeshi Nakano
Pages: 559-563
Published online on: 01 October 2006

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Article

Estradiol and resveratrol stimulating effect on osteocalcin, but not osteonectin and collagen-1α gene expression in primary culture of rat calvarial osteoblast-like cells

Marcin Rucinski, Agnieszka Ziolkowska, Anna Hochol, Andrzej Pucher, Carlo Macchi, Anna S. Belloni, Gastone G. Nussdorfer, Ludwik K. Malendowicz
Pages: 565-570
Published online on: 01 October 2006

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Article

Role of vascular endothelial growth factor in protein loss of Ménétrier's disease

Teiko Takeda, Keiichi Mitsuyama, Osamu Tsuruta, Shinichi Kuboyama, Shigehiko Kitazaki, Michio Sata
Pages: 571-576
Published online on: 01 October 2006

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Article

TGFβ induces transdifferentiation of iBREC to αSMA-expressing cells

Heidrun Deissler, Helmut Deissler, Gerhard K. Lang, Gabriele E. Lang
Pages: 577-582
Published online on: 01 October 2006

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Article

Inhibitory action of C22-fatty acids on DNA polymerases and DNA topoisomerases

Yuko Yonezawa, Takahiko Hada, Keisuke Uryu, Hiroshi Iijima, Hiromi Yoshida, Yoshiyuki Mizushina
Pages: 583-588
Published online on: 01 October 2006

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Article

Mutational analysis of Kir6.1 in Japanese patients with coronary spastic angina

Hirofumi Tomita, Satoko Sasaki, Tomohiro Osanai, Takao Nakano, Takumi Higuma, Jin Yokoyama, Hiroyuki Hanada, Minoru Yasujima, Ken Okumura
Pages: 589-591
Published online on: 01 October 2006

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Article

crv4, a mouse model for human ataxia associated with kyphoscoliosis caused by an mRNA splicing mutation of the metabotropic glutamate receptor 1 (Grm1)

Valerio Conti, Asadollah Aghaie, Michele Cilli, Natalia Martin, Gianluca Caridi, Luca Musante, Giovanni Candiano, Maura Castagna, Alfonso Fairen, Roberto Ravazzolo, Jean-Louis Guenet, Aldamaria Puliti
Pages: 593-600
Published online on: 01 October 2006

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Article

The immediate upstream sequence of the mouse Ret gene controls tissue-specific expression in transgenic mice

Paola Zordan, Sara Tavella, Antonella Brizzolara, Roberta Biticchi, Isabella Ceccherini, Silvio Garofalo, Roberto Ravazzolo, Renata Bocciardi
Pages: 601-608
Published online on: 01 October 2006

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Article

Using caffeoyl pyrrolidine derivative LY52, a potential inhibitor of matrix metalloproteinase-2, to suppress tumor invasion and metastasis

Xian-Jun Qu, Yun-Xia Yuan, Zhi-Gang Tian, Wen-Fang Xu, Ming-Hui Chen, Shu-Xiang Cui, Qian Guo, Ruoyan Gai, Masatoshi Makuuchi, Munehiro Nakata, Wei Tang
Pages: 609-614
Published online on: 01 October 2006

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Article

Leptin and leptin receptors in the prostate and seminal vesicles of the adult rat

Witold Malendowicz, Marcin Rucinski, Carlo Macchi, Raffaella Spinazzi, Agnieszka Ziolkowska, Gastone G. Nussdorfer, Zbigniew Kwias
Pages: 615-618
Published online on: 01 October 2006

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Article

Coexistence of psoriasis and pemphigoid - only a coincidence?

Maciej Lazarczyk, Katarzyna Wozniak, Norito Ishii, Anna Gorkiewicz-Petkov, Takashi Hashimoto, Robert Schwarz, Cezary Kowalewski
Pages: 619-623
Published online on: 01 October 2006

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Article

Methylation of green tea polyphenols affects their binding to and inhibitory poses of the proteasome β5 subunit

Kenyon G. Daniel, Kristin R. Landis-Piwowar, Di Chen, Sheng Biao Wan, Tak-Hang Chan, Q. Ping Dou
Pages: 625-632
Published online on: 01 October 2006

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Article

In utero transplantation of human hematopoietic stem/progenitor cells partially repairs injured liver in mice

Hui Qian, Juan Wang, Shu Wang, Zhijuan Gong, Meijue Chen, Zhaorui Ren, Shuzhen Huang
Pages: 633-642
Published online on: 01 October 2006

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Article

Multiple colon carcinomas in a patient with Cowden syndrome

Anja-Katrin Bosserhoff, Elke-Ingrid Grussendorf-Conen, Albert Rübben, Sabine Rudnik-Schöneborn, Klaus Zerres, Reinhard Buettner, Sabine Merkelbach-Bruse
Pages: 643-647
Published online on: 01 October 2006

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Article

Identification of the mineralocorticoid receptor in human spermatozoa

Cristina Fiore, Daniele Sticchi, Donatella Pellati, Sante Forzan, Guglielmo Bonanni, Alessandro Bertoldo, Michele Massironi, Lorenzo Calò, Ambrogio Fassina, Gian Paolo Rossi, Decio Armanini
Pages: 649-652
Published online on: 01 October 2006

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Article

Identification and characterization of the human StARD9 gene in the LGMD2A-region on chromosome 15q15 by in silico methods

Niels Halama, Silke A. Grauling-Halama, Dirk Jäger Shimizu
Pages: 653-656
Published online on: 01 October 2006

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Article

Inhibition of oxidative stress-induced invasiveness of cancer cells by Ganoderma lucidum is mediated through the suppression of interleukin-8 secretion

Anita Thyagarajan, Jiahua Jiang, Amber Hopf, Jiri Adamec, Daniel Sliva
Pages: 657-664
Published online on: 01 October 2006

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Article

Involvement of nuclear factor I-A1 in the regulation of regucalcin gene promoter activity in cloned normal rat kidney proximal tubular epithelial cells

Natsumi Sawada, Masayoshi Yamaguchi
Pages: 665-671
Published online on: 01 October 2006

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Article

Morphological identification of hepatitis C virus E1 and E2 envelope glycoproteins on the virion surface using immunogold electron microscopy

Masahiko Kaito, Shozo Watanabe, Hideaki Tanaka, Naoki Fujita, Masayoshi Konishi, Motoh Iwasa, Yoshinao Kobayashi, Esteban Cesar Gabazza, Yukihiko Adachi, Kyoko Tsukiyama-Kohara, Michinori Kohara
Pages: 673-678
Published online on: 01 October 2006

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Article

Effects of lysine to arginine mutations in HIV-1 Vif on its expression and viral infectivity

Boonruang Khamsri, Mikako Fujita, Kazuya Kamada, Ahmad Piroozmand, Tomoki Yamashita, Tsuneo Uchiyama, Akio Adachi
Pages: 679-683
Published online on: 01 October 2006

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Article

Microarray profiling of gene expression patterns in glomerular cells of astaxanthin-treated diabetic mice: A nutrigenomic approach

Yuji Naito, Kazuhiko Uchiyama, Katsura Mizushima, Masaaki Kuroda, Satomi Akagiri, Tomohisa Takagi, Osamu Handa, Satoshi Kokura, Norimasa Yoshida, Hiroshi Ichikawa, Jiro Takahashi, Toshikazu Yoshikawa
Pages: 685-695
Published online on: 01 October 2006

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Article

Protection of aortic endothelial function in both normal and diabetic rats by intravenous bolus injection of a medium-chain triglyceride: fish oil emulsion

David Fontaine, Anne Otto, Laurence Portois, Jeanine Fontaine, Guy Berkenboom, Willy J. Malaisse, Yvon A. Carpentier
Pages: 697-704
Published online on: 01 October 2006

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Article

Comparison of human chorionic gonadotropin +β and invasive trophoblast antigen disappearance rates in serum after evacuation of molar pregnancy

Nienke E. Van Trommel, Fred C. G.J. Sweep, H. Alec Ross, Leon F. A.G. Massuger, Chris M.G. Thomas
Pages: 705-711
Published online on: 01 October 2006

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Article

UVB radiation induces expression of HIF-1α and VEGF through the EGFR/PI3K/DEC1 pathway

Yanhua Li, Zhigang Bi, Bingfang Yan, Yinsheng Wan
Pages: 713-719
Published online on: 01 October 2006

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Article

Mucosal function in rat jejunum and ileum is altered by induction of colitis

Einat Amit-Romach, Ram Reifen, Zehava Uni
Pages: 721-727
Published online on: 01 October 2006

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Article

Sequence analysis shows that Lifeguard belongs to a new evolutionarily conserved cytoprotective family

Kerstin Reimers, Claudia Y.-U. Choi, Eddy Mau-Thek, Peter M. Vogt
Pages: 729-734
Published online on: 01 October 2006

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Article

Role of bone morphogenetic protein 2 in the crosstalk between endothelial progenitor cells and mesenchymal stem cells

M. Raida, A. C. Heymann, C. Günther, D. Niederwieser
Pages: 735-739
Published online on: 01 October 2006

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Article

Acute in vivo administration of a fish oil-containing emulsion improves post-ischemic cardiac function in n-3-depleted rats

S. Peltier, W. J. Malaisse, L. Portois, L. Demaison, V. Novel-Chate, J. M. Chardigny, J. L. Sebedio, Y. A. Carpentier, X. M. Leverve
Pages: 741-749
Published online on: 01 October 2006

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Article

A conditionally replicative adenovirus that codes for a TK-GFP fusion protein (Ad5Δ24TK-GFP) for evaluation of the potency of oncolytic virotherapy combined with molecular chemotherapy

Tanja Hakkarainen, Akseli Hemminki, David T. Curiel, Jarmo Wahlfors
Pages: 751-759
Published online on: 01 October 2006

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Article

Preclinical investigations of a medium-chain triglyceride:fish oil emulsion. I. Effects of bovine milk lipoprotein lipase on lipid composition

Yvon A. Carpentier, Isabelle Dupont, Laurence Portois, Willy J. Malaisse
Pages: 761-773
Published online on: 01 October 2006

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Article

Proteomic analysis of rat cerebral cortex, hippocampus and striatum after exposure to morphine

Anna Bierczynska-Krzysik, Julius Paul Pradeep John, Jerzy Silberring, Jolanta Kotlinska, Tomasz Dylag, Maureen Cabatic, Gert Lubec
Pages: 775-784
Published online on: 01 October 2006

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Article

The effect of stromal cell-derived factor 1 (SDF1/CXCL12) genetic polymorphism on HIV-1 disease progression

Edna Maria Vissoci Reiche, Maria Angelica Ehara Watanabe, Ana Maria Bonametti, Helena Kaminami Morimoto, Arilson Akira Morimoto, Susana Lilian Wiechmann, Jose Wander Breganó, Tiemi Matsuo, Fernando Vissoci Reiche, Helen Cristina Miranda, Karen Brajão Oliveira, Ingridt Hildegard Vogler, Alexandra Regina Siscar
Pages: 785-793
Published online on: 01 October 2006

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Journal Cover
February-2026 Volume 57 Issue 2

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

miR‑205: A dual regulator of angiogenesis in health and disease (Review)

Maria Oltra, Miriam Martínez‑Santos, Maria Ybarra, Maria Pires, Chiara Ceresoni, Clara Gomis‑Coloma, Cristina Medina‑Trillo, Javier Sancho, Jorge Barcia
Article Number: 51
Published online on: 29 December 2025

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Astragaloside IV: A multipotent phytochemical for treating fibrotic diseases (Review)

Mingyu Wu, Ke Li, Jiabin Wu, Qiuyu Zhang, Xiaotong Ma, Wei Dai, Haoyang Gao, Xianyi Ding, Wenhong Wang, Weihua Xiao
Article Number: 50
Published online on: 24 December 2025

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Activating transcription factors: Orchestrators of macrophage biology in pathological settings (Review)

Yue-Chen Liu, Jia-Wei Zhao, Xiong-Tao Yue, Qi-Jie Chen, Shan-Jie Rong, Shi-Wei Liu, Fei Sun, Chun-Liang Yang, Cong-Yi Wang
Article Number: 49
Published online on: 24 December 2025

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Role of SIRT3 in digestive system diseases and therapeutic prospects (Review)

Jiajia Li, Qian Liu, Shun Yao, Xin Li, Li Zhang, Yongfeng Wang, Guorong Wen, Jiaxing An, Hai Jin, Biguang Tuo
Article Number: 48
Published online on: 22 December 2025

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Recombinant ADAMTS‑1 promotes muscle regeneration accompanied by downregulation of Notch signaling

Jin-Hwa Kim, Sang-Hyup Lee, Sang-Yoon Kim, Jeong-Won Kim, Ji-Soo Jeong, Eun-Hye Chung, Su-Ha Lee, Chang-Yeop Kim, Bong-Keun Choi, Je-Won Ko, Tae-Won Kim
Article Number: 47
Published online on: 22 December 2025

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A comprehensive review on pain: Model, target, therapy, and prospect (Review)

Chenyu Chang, Xutao Wu, Kejia Liu, Lei Wang, Mozili Adu, Qingyuan Lin, Huilian Huang, Qinge Ma, Rongrui Wei, Xiaoyun Wang, Wenmin Liu
Article Number: 46
Published online on: 17 December 2025

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Retraction Open Access

[Retracted] Curculigoside attenuates myocardial ischemia‑reperfusion injury by inhibiting the opening of the mitochondrial permeability transition pore

Yanbing Zhao, Yuxuan Guo, Yuqiong Chen, Shuang Liu, Nan Wu, Dalin Jia
Article Number: 45
Published online on: 15 December 2025

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Nanomaterials and exercise interventions: A synergistic approach for atherosclerosis therapy (Review)

Quanquan Zhou, Ge‑Lin Zhang, Weitong Sun, Jiayi Cai, Li-Hua Yu
Article Number: 44
Published online on: 10 December 2025

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Selective autophagic degradation of glycolytic activator PFKFB3 contributes to maintaining intestinal epithelial barrier in inflammatory bowel disease

Yiyang Pan, Feng Yang, Liucan Wang, Tianshu Yang, Guangsheng Du, Cong Xu, Hua Yang, Min Yu, Weidong Xiao
Article Number: 43
Published online on: 10 December 2025

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Lactylation‑mediated ferroptosis: A novel mechanism and therapeutic prospects in human diseases (Review)

Zhengjun Lin, Yugang Zou, Songzhu Zou, Kunming Wen
Article Number: 42
Published online on: 08 December 2025

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Dual role of lactate in ferroptosis: Mechanisms, pathophysiology and therapeutic opportunities (Review)

Qian Yu, Yu Kuang, Jie He, Li Yang, Xinjie Li, Hao Yu
Article Number: 41
Published online on: 08 December 2025

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Retraction Open Access

[Retracted] MicroRNA‑493‑5p promotes apoptosis and suppresses proliferation and invasion in liver cancer cells by targeting VAMP2

Guannan Wang, Xiaosan Fang, Meng Han, Xiaoming Wang, Qiang Huang
Article Number: 40
Published online on: 08 December 2025

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FGF4 alleviates the lung cell damage caused by high glucose via AMPK‑PGC‑1 signaling axis in vitro and in vivo

Qiujuan Fu, Yongfang Ou, Qin Wu, Jue Gong, Feixia Li, Tuxing Wang, Zhitai Lin, Kejie Huang, Jianlong Xie
Article Number: 39
Published online on: 05 December 2025

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STOML2 interacts with PHB to activate the MEK/ERK signaling pathway and mediates autophagy‑related proteins in the progression of hepatocellular carcinoma

Haoyang Hu, Haozhe Zhang, Shuai Han, Jianli Chen, Ying Xie
Article Number: 38
Published online on: 04 December 2025

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HMGB1 mediates low-dose ionizing radiation-induced Wnt/β-catenin activation in SRA01/04 cells: Mechanistic clues to early cataractogenesis

Ping Wang, Chunnan Piao, Dong Yan, Yingxue He, Yaru Li, Li Fan, Mei Tian
Article Number: 37
Published online on: 04 December 2025

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FBXO22 promotes hepatocellular carcinoma progression via paracrine myo‑inositol‑induced M2‑type polarization of macrophages

Liangliang Bai, Jing Xiong, Sihai Chen, Jiahao Hu, Meixia Zhang, Bimin Li, Jing Hu, Mingyan He
Article Number: 36
Published online on: 02 December 2025

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Branched‑chain amino acid metabolism and bone metabolism: Implications for osteoporosis pathogenesis and therapeutic strategies (Review)

Qi Xiao, Haimin Zeng, Ruhui Yang, Yuxin Zhan, Fangzhen Lin, Bofan Chen, Xiang Chen
Article Number: 35
Published online on: 02 December 2025

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Mitochondria-associated endoplasmic reticulum membranes: Emerging regulators of cardiac microvascular ischemia/reperfusion injury (Review)

Yan Wang, Baowei Feng, Yanting Wu, Zongle Sun, Hao Yuan, Wei Chen, Chang Zhao, Zhi Liu
Article Number: 34
Published online on: 02 December 2025

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Role of matrix metalloproteinases in the invasion of glioblastoma and drug interventions (Review)

Bohao Zheng, Ying Han, Haiying Zhang
Article Number: 33
Published online on: 01 December 2025

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Review

Bridging bench to bedside: Exosome‑based strategies for endometriosis diagnosis and treatment (Review)

Wanmeng Chen, Yujiu Ma, Xudong Zhang, Siwen Zhang, Shanshan Wu, Yimeng Lu, Jichun Tan
Article Number: 32
Published online on: 01 December 2025

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Retraction Open Access

[Retracted] miR‑381 functions as a tumor suppressor by targeting ETS1 in pancreatic cancer

Guanen Qiao, Jing Li, Jun Wang, Zhaoyang Wang, Wei Bian
Article Number: 31
Published online on: 01 December 2025

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Journal Cover
March-2026 Volume 57 Issue 3

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Retraction Open Access

[Retracted] Mechanism of cell death induced by silica nanoparticles in hepatocyte cells is by apoptosis

Ye Yang, Xinjing Du, Qiang Wang, Jianwei Liu, Enguo Zhang, Linlin Sai, Cheng Peng, Martin F. Lavin, Abrey Jie Yeo, Xu Yang, Hua Shao, Zhongjun Du
Article Number: 59
Published online on: 12 January 2026

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Review Open Access

ZG16B: A key regulator of tumor progression and immune microenvironment modulation in cancer (Review)

Xing-Ming Chen, Yu-Bo Liang, Jin-Xiang Zuo, Zi-Sheng Yang, Le-Yu Zhang, Xin-Yu Zhang, Ping Wan, Yang Ke
Article Number: 58
Published online on: 09 January 2026

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Retraction Open Access

[Retracted] Silica nanoparticles induce cardiomyocyte apoptosis via the mitochondrial pathway in rats following intratracheal instillation

Zhongjun Du, Shangya Chen, Guanqun Cui, Ye Yang, Enguo Zhang, Qiang Wang, Martin F. Lavin, Abrey J. Yeo, Cunxiang Bo, Yu Zhang, Chao Li, Xiaoshan Liu, Xu Yang, Cheng Peng, Hua Shao
Article Number: 57
Published online on: 05 January 2026

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Review Open Access

Role of cuproptosis in digestive system tumors (Review)

Li Zhang, Yongpeng Cheng, Lulu Tang, Jiaxing Zhu, Biguang Tuo
Article Number: 56
Published online on: 02 January 2026

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Review Open Access

Environmental exposure to air pollution and climate: Intersecting the impact on ear and nose health and chemosensory function (Review)

Yu-Chen Zhang, Lei Zhang, Ping-Ting Zhou, Zi-Hui Xie, Wen-Jie Zhang, Min Fan, Yan-Xun Han, Ye-Hai Liu, Yu-Chen Liu
Article Number: 55
Published online on: 31 December 2025

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Review Open Access

Role and mechanisms of ferroptosis in cognitive impairment: From molecular pathways to therapeutic targets (Review)

Shenghui Ge, Deyue Kong, Shuyue Fan, Yi Luo, Xiao Yin, Zehua Jin, Wenqing Xia, Jianhua Ma
Article Number: 54
Published online on: 30 December 2025

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Review Open Access

The GPR124‑Wnt‑PPARγ regulatory axis: Molecular mechanisms and therapeutic implications in chronic inflammatory diseases (Review)

Ming-Wang Cui, Si-Yu Tao, Tao Wen, Zhu-Ling Guo
Article Number: 53
Published online on: 30 December 2025

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Review Open Access

Advances in RPGR gene therapy for X‑linked retinitis pigmentosa: From preclinical insights to clinical application (Review)

Yushan Long, Jia Qi, Wenliang Zhang, Huan Qin, Kai Yao
Article Number: 52
Published online on: 30 December 2025

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