Neuromedin U receptor 1 expression in the rat endocrine pancreas and evidence suggesting neuromedin U suppressive effect on insulin secretion from isolated rat pancreatic islets

Kaczmarek,Przemyslaw; Malendowicz,Ludwik K.; Pruszynska-Oszmalek,Ewa; Wojciechowicz,Tatiana; Szczepankiewicz,Dawid; Szkudelski,Tomasz; Nowak,Krzysztof W.

doi:10.3892/ijmm.18.5.951

November 2006 Volume 18 Issue 5

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November 2006 Volume 18 Issue 5

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Article

Neuromedin U receptor 1 expression in the rat endocrine pancreas and evidence suggesting neuromedin U suppressive effect on insulin secretion from isolated rat pancreatic islets

Authors:
- Przemyslaw Kaczmarek
- Ludwik K. Malendowicz
- Ewa Pruszynska-Oszmalek
- Tatiana Wojciechowicz
- Dawid Szczepankiewicz
- Tomasz Szkudelski
- Krzysztof W. Nowak
View Affiliations / Copyright

Affiliations: Department of Animal Physiology and Biochemistry, August Cieszkowski University of Agriculture, 60-637 Poznan, Poland. przekacz@au.poznan.pl
Pages: 951-955
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Published online on: November 1, 2006

https://doi.org/10.3892/ijmm.18.5.951
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Abstract

Neuromedin U (NmU) is a regulatory peptide found in significant concentrations in both the brain and gut of the rat and is named according to its ability to powerfully contract the uterus. Two types of NmU receptors were recently identified and subsequent studies evidenced NmU involvement in the regulation of energy homeostasis. Such a role of neuromedin U suggests that a polypeptide may also be involved in the regulation of adipoinsular axis function. Therefore in the present study we examined the expression of NmU receptors in pancreatic islets using RT-PCR and Western blotting analysis. We also investigated the role of NmU in regulation of insulin secretion in vitro using isolated pancreatic islets. We have confirmed that NmUR1 but not NmUR2 is specifically expressed in isolated rat pancreatic islets. In all tested doses (1, 10, 100 nmol/l) NmU dose- dependently decreased insulin output by isolated pancreatic islets. These inhibitory effects of NmU on insulin secretion may suggest the involvement of NmU in regulating the pancreatic branch of adipoinsular axis function. Thus, NmU can be included in that group of anorectic peptides, which are also involved in the regulation of insulin secretion.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Neuromedin U receptor 1 expression in the rat endocrine pancreas and evidence suggesting neuromedin U suppressive effect on insulin secretion from isolated rat pancreatic islets

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Abstract

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