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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
November 2006 Volume 18 Issue 5

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Article

Williams-Beuren syndrome: Determination of deletion size using quantitative real-time PCR

Cornelia Schubert, Franco Laccone
Pages: 799-806
Published online on: 01 November 2006

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Article

Local in vivo administration of a decoy oligonucleotide targeting NF-κB induces apoptosis of osteoclasts after application of orthodontic forces to rat teeth

Letizia Penolazzi, Eros Magri, Elisabetta Lambertini, Girolamo Calò, Mauro Cozzani, Giuseppe Siciliani, Roberta Piva, Roberto Gambari
Pages: 807-811
Published online on: 01 November 2006

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Article

Endothelial cells from human cerebral aneurysm and arteriovenous malformation release ET-1 in response to vessel rupture

Elisa Boscolo, Giacomo Pavesi, Paolo Zampieri, Maria Teresa Conconi, Chiara Calore, Renato Scienza, Pier Paolo Parnigotto, Marcella Folin
Pages: 813-819
Published online on: 01 November 2006

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Article

Inflammatory response of esophageal epithelium in combined-type esophagitis in rats: a transcriptome analysis

Yuji Naito, Masaaki Kuroda, Kazuhiko Uchiyama, Katsura Mizushima, Satomi Akagiri, Tomohisa Takagi, Osamu Handa, Satoshi Kokura, Norimasa Yoshida, Hiroshi Ichikawa, Toshikazu Yoshikawa
Pages: 821-828
Published online on: 01 November 2006

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Article

Natural killer T cells ameliorate antibody-induced arthritis in macrophage migration inhibitory factor transgenic mice

Dai Takagi, Kazuya Iwabuchi, Masanori Maeda, Yuji Nakamaru, Yasushi Furuta, Satoshi Fukuda, Luc Van Kaer, Jun Nishihira, Kazunori Onoé
Pages: 829-836
Published online on: 01 November 2006

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Article

Metabolic activity of rat hepatocytes cultured on homologous acellular matrix and transplanted into Gunn rats

Silvia Tomat, Patrizia Burra, Enrico Gringeri, Umberto Cillo, Fiorella Calabrese, Cinzia Giacometti, Paolo Carraro, Carlo Macchi, Gastone G. Nussdorfer, Pier Paolo Parnigotto
Pages: 837-842
Published online on: 01 November 2006

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Article

Genetic factors for obesity

Yoshiji Yamada, Kimihiko Kato, Takashi Kameyama, Kiyoshi Yokoi, Hitoshi Matsuo, Tomonori Segawa, Sachiro Watanabe, Sahoko Ichihara, Hidemi Yoshida, Kei Satoh, Yoshinori Nozawa
Pages: 843-851
Published online on: 01 November 2006

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Article

The mismatch repair gene hPMS2 is mutated in primary breast cancer

Gabriela A. Balogh, Rebecca C. Heulings, Jose Russo
Pages: 853-857
Published online on: 01 November 2006

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Article

Ex vivo HR-MAS MRS of human meningiomas: A comparison with in vivo 1H MR spectra

Vitaliano Tugnoli, Luisa Schenetti, Adele Mucci, Francesca Parenti, Rita Cagnoli, Valeria Righi, Andrea Trinchero, Luca Nocetti, Cristian Toraci, Luciano Mavilla, Gianpaolo Trentini, Elena Zunarelli, M. Raffaella Tosi
Pages: 859-869
Published online on: 01 November 2006

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Article

Genetic risk for atherothrombotic cerebral infarction in individuals stratified by sex or conventional risk factors for atherosclerosis

Sachiyo Yamaguchi, Yoshiji Yamada, Norifumi Metoki, Hidemi Yoshida, Kei Satoh, Sahoko Ichihara, Kimihiko Kato, Takashi Kameyama, Kiyoshi Yokoi, Hitoshi Matsuo, Tomonori Segawa, Sachiro Watanabe, Yoshinori Nozawa
Pages: 871-883
Published online on: 01 November 2006

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Article

Dual regulation of soluble tumor necrosis factor-α induced activation of human monocytic cells via modulating transmembrane TNF-α-mediated ‘reverse signaling’

Lijun Xin, Jing Wang, Hailong Zhang, Wenfang Shi, Mingxia Yu, Qingfen Li, Xiaodan Jiang, Feili Gong, Kevin Gardner, Qingdi Q. Li, Zhuoya Li
Pages: 885-892
Published online on: 01 November 2006

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Article

Suppressive effect of non-anaphylactogenic anti-IgE antibody on the development of dextran sulfate sodium-induced colitis

Ok-Hwa Kang, Dae-Ki Kim, Yeon-A Choi, Hye-Jung Park, Jin Tae, Chon-Sik Kang, Suck-Chei Choi, Yong-Ho Nah, Hern-Ku Lee, Young-Mi Lee
Pages: 893-899
Published online on: 01 November 2006

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Article

Transcriptional targeting of virus-mediated gene transfer by the human hexokinase II promoter

Ann-Marie Määttä, Sanna Korja, Heli Venhoranta, Tanja Hakkarainen, Eija Pirinen, Sami Heikkinen, Riikka Pellinen, Kimmo Mäkinen, Jarmo Wahlfors
Pages: 901-908
Published online on: 01 November 2006

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Article

Enhancement of radiosensitivity by topoisomerase II inhibitor, amrubicin and amrubicinol, in human lung adenocarcinoma A549 cells and kinetics of apoptosis and necrosis induction

Sachiko Hayashi, Masanori Hatashita, Hideki Matsumoto, Hiroki Shioura, Ryuhei Kitai, Eiichi Kano
Pages: 909-915
Published online on: 01 November 2006

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Article

Multiple splicing variants of Naf1/ABIN-1 transcripts and their alterations in hematopoietic tumors

Yasuhiro Shiote, Mamoru Ouchida, Yoshimi Jitsumori, Yoichiro Ogama, Yoshinobu Matsuo, Fumihiko Ishimaru, Mitsune Tanimoto, Kenji Shimizu
Pages: 917-923
Published online on: 01 November 2006

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Article

Functional characterization of histamine receptor subtypes in a human bronchial epithelial cell line

Tobias Müller, Daniel Myrtek, Hannes Bayer, Stephan Sorichter, Katrin Schneider, Gernot Zissel, Johannes Norgauer, Marco Idzko
Pages: 925-931
Published online on: 01 November 2006

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Article

Association of phosphodiesterase 4D gene polymorphisms with chronic obstructive pulmonary disease: Relationship to interleukin 13 gene polymorphism

Shinsuke Homma, Tohru Sakamoto, Ahmed E. Hegab, Wataru Saitoh, Akihiro Nomura, Yukio Ishii, Yuko Morishima, Takashi Iizuka, Takumi Kiwamoto, Yosuke Matsuno, Hosam H. Massoud, Hosny M. Massoud, Khalid M. Hassanein, Kiyohisa Sekizawa
Pages: 933-939
Published online on: 01 November 2006

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Article

Tumour-stroma interactions between metastatic prostate cancer cells and fibroblasts

Annette Kaminski, Jens Claus Hahne, El-Mustapha Haddouti, Alexandra Florin, Axel Wellmann, Nicolas Wernert
Pages: 941-950
Published online on: 01 November 2006

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Article

Neuromedin U receptor 1 expression in the rat endocrine pancreas and evidence suggesting neuromedin U suppressive effect on insulin secretion from isolated rat pancreatic islets

Przemyslaw Kaczmarek, Ludwik K. Malendowicz, Ewa Pruszynska-Oszmalek, Tatiana Wojciechowicz, Dawid Szczepankiewicz, Tomasz Szkudelski, Krzysztof W. Nowak
Pages: 951-955
Published online on: 01 November 2006

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Article

The effects of macrophage migratory inhibitory factor on acute-phase protein production in primary human hepatocytes

Nicholas M. Wheelhouse, Nabil Dowidar, Cornelis H.C. Dejong, O. James Garden, James J. Powell, Matthew D. Barber, Kathryn Sangster, Jean P. Maingay, James A. Ross
Pages: 957-961
Published online on: 01 November 2006

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Article

Expression of the Nd1 gene is down-regulated by doxorubicin at post-transcriptional level

Yasuyuki Takamori, Yuji Matsudo, Lisa Fujimura, Myengmo Kang, Yoshitada Harada, Hideshige Moriya, Takeshi Tokuhisa, Masahiko Hatano
Pages: 963-967
Published online on: 01 November 2006

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Review

Hemostasis alterations in metabolic syndrome (Review)

Iván Palomo, Marcelo Alarcón, Rodrigo Moore-Carrasco, Josep M. Argilés
Pages: 969-974
Published online on: 01 November 2006

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Article

Antiangiogenic activity of a concentrated effective microorganism fermentation extract

Chung Hin Chui, Roberto Gambari, Fung Yi Lau, Desmond Kwok Po Hau, Raymond Siu Ming Wong, Gregory Yin Ming Cheng, Stanton Hon Lung Kok, Teruo Higa, Bin Ke, Albert Sun Chi Chan, David Wan Fun Fong, Johnny Cheuk On Tang
Pages: 975-979
Published online on: 01 November 2006

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Article

Com-1/p8 acts as a putative tumour suppressor in prostate cancer

Wen G. Jiang, Gaynor Davies, Tracey A. Martin, Howard Kynaston, Malcolm D. Mason, Oystein Fodstad
Pages: 981-986
Published online on: 01 November 2006

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Article

Pro-oxidative effects of tea and polyphenols, epigallocatechin-3-gallate and epigallocatechin, on G6PD-deficient erythrocytes in vitro

Chun Hay Ko, Karen Li, Pak Cheung Ng, Kwok Pui Fung, Chung Leung Li, Raymond Pui-On Wong, Kit Man Chui, Goldie Jia-Shi Gu, Edmund Yung, Chi Chiu Wang, Tai Fai Fok
Pages: 987-994
Published online on: 01 November 2006

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Article

Development and evaluation of a colorimetric PCR system for the detection and typing of human papillomaviruses

Diego Chouhy, Lisandro Benítez Gil, Ana L. Nocito, Daniel Wojdyla, Leonardo Ornella, Jorge Cittadini, Daniela Gardiol, Adriana A. Giri
Pages: 995-1003
Published online on: 01 November 2006

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Journal Cover
May-2026 Volume 57 Issue 5

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Article Open Access

Macrophage SH3 domain‑containing GRB2‑like protein B1 is required for Rab7‑mediated mitophagy in inflammation during sea water drowning acute lung injury

Hongjuan Ning, Jingyu Deng, Yongheng Gao, Wei Zhang, Jian Chen, Xian Guo, Faguang Jin
Article Number: 138
Published online on: 24 March 2026

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Article Open Access

Deferoxamine mitigates neuronal loss following spinal cord injury via ferroptosis inhibition and Nrf2/HO‑1 pathway activation

Ziqian Ma, Xinwei Zhang, Tao Liu, Yan Zhang, Guanghao Li, Xin Yuan, Benqiang Tang, Hangyi Zhao, Liang Liu, Xueming Chen
Article Number: 137
Published online on: 23 March 2026

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Review Open Access

USP10 deubiquitinase: Physiological function, diseases and therapeutic target (Review)

Linlin Zhang, Huajing Sun, Zifan Wang, Zhimei Wang, Qiang Mu, Yukun Liu
Article Number: 136
Published online on: 23 March 2026

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Article Open Access

Siglec‑15 dysregulation and its therapeutic implications in new‑onset type 1 diabetes 

Heming Guo, Yunwen Tao, Sicheng Li, Ying Gu, Yiting Huang, Chen Fang, Ji Hu
Article Number: 135
Published online on: 20 March 2026

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Article Open Access

ZEB1 maintains mitochondrial fission and macrophage efferocytosis by restraining MFN2, thereby limiting inflammation and improving tendon‑bone healing

Yan Zhao, Yuankai Zhang, Tian Lei, Shangqing Zhang, Kai Nan, Xin Zhang, Li-Hong Fan
Article Number: 134
Published online on: 19 March 2026

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Review Open Access

Targeting pyroptosis in renal fibrosis: From molecular mechanisms to therapeutic horizons (Review)

Yihuai Tian, Quwu Mushuo, Hui Fan, Hongwei Su, Jianchun Li, Qiong Zhang
Article Number: 133
Published online on: 19 March 2026

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Expression of Concern Open Access

[Expression of Concern] Fasudil, a Rho‑associated protein kinase inhibitor, attenuates retinal ischemia and reperfusion injury in rats

Haishan Song, Dianwen Gao
Article Number: 132
Published online on: 18 March 2026

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Review Open Access

Epigenetic regulation in a high-sugar environment (Review)

Huili Zhou, Xinhe Lv, Yu Liang, Dehai Yu, Wanning Wang
Article Number: 131
Published online on: 17 March 2026

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Review Open Access

The roles and heterogeneity of CD8+ T cells in inflammatory bowel disease: A narrative review of insights from single‑cell transcriptomics (Review)

Rui Zhong, Jing Guo, Wujie Ye, Zhihui Deng, Huangan Wu, Qin Qi, Guona Li, Lu Zhu, Yan Huang, Luyi Wu
Article Number: 130
Published online on: 17 March 2026

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Review Open Access

Mechanism of action and clinical application of autophagy in multiple sclerosis (Review)

Dongmei Wang, Qizhi Fu, Ying Zhao, Guangda Li, Yongjie Bai, Yang Yang, Hongna Song, Mingwei Wang, Hua Fan
Article Number: 129
Published online on: 17 March 2026

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Expression of Concern Open Access

[Expression of Concern] Insulin‑dependent diabetes mellitus decreases osteoblastogenesis associated with the inhibition of Wnt signaling through increased expression of Sost and Dkk1 and inhibition of Akt activation

Mamiko Hie, Natsumi Iitsuka, Tomoyo Otsuka, Ikuyo Tsukamoto
Article Number: 128
Published online on: 16 March 2026

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Mechanotransduction and its impact on regenerative medicine in orthopedic rehabilitation (Review)

Baohui Wang, Xueqin Zeng, Huajian Liu, Liang Li, Tao Lei, Yafeng Li, Qing Fang, Yi Cao, Bo Dong
Article Number: 127
Published online on: 13 March 2026

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Article Open Access

4‑Acetylantrocamol LT3 suppresses colorectal cancer growth and metastasis via PI3K/AKT and MAPK pathway modulation

Kuen-Tze Lin, Yu-Chieh Hsieh, Pi-Kai Chang, Chih-Wei Lai, Shih-Yu Lee, I-Chuan Yen
Article Number: 126
Published online on: 13 March 2026

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Review Open Access

Roles of ubiquitin‑specific peptidase 22 in cellular fate: From embryonic survival to tissue repair, inflammation and metabolism (Review)

Jia-Nan Xiang, Chen-Yang Zhou, Yu-Di Zhao, Xiao Xu, Sun-Bin Ling
Article Number: 125
Published online on: 12 March 2026

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m6A in adipose tissue inflammation: A novel regulator of obesity and metabolic diseases (Review)

Xiaoting Yang, Xiaodan Wang, Haojun Tang, Shuangxi Tu, Kai Yin, Xiao Zhu
Article Number: 124
Published online on: 12 March 2026

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Expression of Concern Open Access

[Expression of Concern] Visfatin/PBEF/Nampt induces EMMPRIN and MMP‑9 production in macrophages via the NAMPT‑MAPK (p38, ERK1/2)‑NF‑κB signaling pathway

Yuqi Fan, Shu Meng, Yue Wang, Jiatian Cao, Changqian Wang
Article Number: 123
Published online on: 12 March 2026

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Article Open Access

IL‑37/IL‑1R8 blocks keratinocyte acantholysis via suppressing ADAM17/EGFR

Fengxia Hu, Wenjing Chen, Qian Wang, Xiaoyu Zhang, Fuyang Xiao, Jinying Zhang, Junqin Liang
Article Number: 122
Published online on: 12 March 2026

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Review Open Access

Reactive oxygen species in fetal growth restriction mechanisms and therapeutic directions (Review)

Di Cheng, Songbin Yang, Cuilan Wang, Kefeng Fan, Fengchun Gao, Qian Sun
Article Number: 121
Published online on: 12 March 2026

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Research progress on the molecular mechanisms of tanshinone IIA in the treatment of cardiovascular and cerebrovascular diseases (Review)

Wen Pei, Ping Lu, Chenhuan Ding, Ying Li, Yong Li
Article Number: 120
Published online on: 12 March 2026

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Ferritin in ferroptosis: Implications for neurodegenerative diseases (Review)

Wenjing Chen, Heng Tian, Ran Wei, Xiaomei Chen, Yiwen Jia
Article Number: 119
Published online on: 12 March 2026

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Correction Open Access

[Corrigendum] Ursolic acid protects against cisplatin‑induced ototoxicity by inhibiting oxidative stress and TRPV1‑mediated Ca2+‑signaling  

Yang Di, Tao Xu, Yuan Tian, Tingting Ma, Donghao Qu, Yan Wang, Yuhan Lin, Dongyan Bao, Li Yu, Shuangyue Liu, Aimei Wang
Article Number: 118
Published online on: 09 March 2026

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Article Open Access

HELLS inhibits autophagy‑dependent ferroptosis in nasopharyngeal carcinoma by modulating the Nrf2/HO‑1/GPX4 pathway

Chengxun Jin, Jinqiu Li, Siqi Han, Chaoluomeng Bai, Jingpu Yang, Zonggui Wang
Article Number: 117
Published online on: 09 March 2026

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Expression of Concern Open Access

[Expression of Concern] Inhibitory effect of curcumin on angiogenesis in ectopic endometrium of rats with experimental endometriosis

Ying Zhang, Hong Cao, Yue-Yue Hu, Hua Wang, Chang-Jun Zhang
Article Number: 116
Published online on: 09 March 2026

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Article Open Access

Propofol upregulates MFG‑E8 in BV2 cells to inhibit pyroptosis mediated by the NF‑κB/NLRP3 pathway, thereby ameliorating ischemic‑reperfusion neuronal injury

Shewei Guo, Yingwei Zhen, Guosheng Zhou, Zhihua Zhao
Article Number: 115
Published online on: 05 March 2026

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Article Open Access

Exosomal circ0000549 promotes MNNG‑induced gastric cancer through miR‑15b‑5p/KIF1B

Zhaofeng Liang, Zihan Gao, Yue Zhang, Jiajia Song, Hui Qian, Xuezhong Xu
Article Number: 114
Published online on: 04 March 2026

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Expression of Concern Open Access

[Expression of Concern] Syringin prevents cardiac hypertrophy induced by pressure overload through the attenuation of autophagy  

Fangfang Li, Ning Zhang, Qingqing Wu, Yuan Yuan, Zheng Yang, Mengqiao Zhou, Jinxiu Zhu, Qizhu Tang
Article Number: 113
Published online on: 04 March 2026

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Review Open Access

Treatment of pulmonary fibrosis: From disease mechanisms to future novel therapies (Review)

Sen Lu, Yunfei Liu, Xiaohua Li, Qipeng Yao
Article Number: 112
Published online on: 03 March 2026

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Review Open Access

Research progress in single‑cell omics technologies for kidney disease (Review)

Jia Xu, Ziwei Chen, Shengyao Li, Xiaoya Wang, Ming Chen
Article Number: 111
Published online on: 03 March 2026

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Review Open Access

CLDN7: Epithelial gatekeeper from physiology to pathology‑roles in cancer and epithelial‑related diseases (Review)

Xiuping Lai, Yan Yan, Lu Sun, Zili Lei, Yanhong Yang
Article Number: 110
Published online on: 03 March 2026

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Dynamic regulation and targeted intervention of neutrophils in hepatic ischemia‑reperfusion injury (Review)

Sen Lu, Jiale Tong, Jing Jiang, Qin Zhang, Youjin Huang
Article Number: 109
Published online on: 03 March 2026

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The dual role of the crosstalk between autophagy and ferroptosis in lung cancer treatment: Advances in mechanisms and therapeutic strategies (Review)

Yingying Zhang, Ruxin Shen
Article Number: 108
Published online on: 02 March 2026

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Mechanistic insights into inflammatory cytokines in adenomyosis‑induced infertility (Review)

Bojiao Yang, Feng Li, Guimao Cao, Mingtu Nuo, Yaxin Shi, Zilu Wang, Jing Jia, Wei Shi, Zhiyong Liu
Article Number: 107
Published online on: 02 March 2026

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Correction Open Access

[Corrigendum] Astragaloside IV promotes the proliferation and migration of osteoblast‑like cells through the hedgehog signaling pathway

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Article Number: 106
Published online on: 02 March 2026

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June-2026 Volume 57 Issue 6

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Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

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Published online on: 26 March 2026

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Expression of Concern Open Access

[Expression of Concern] Involvement of Cyr61 in the growth, invasiveness and adhesion of esophageal squamous cell carcinoma cells

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Novel Hsp90 inhibitor JD‑02 inhibits HSV‑1 infection via the Raf/MEK/ERK signaling pathway

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Published online on: 24 March 2026

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