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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
November 2006 Volume 18 Issue 5

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Journal Metrics

Impact Factor: 8.5

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Article

Williams-Beuren syndrome: Determination of deletion size using quantitative real-time PCR

Cornelia Schubert, Franco Laccone
Pages: 799-806
Published online on: 01 November 2006

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Article

Local in vivo administration of a decoy oligonucleotide targeting NF-κB induces apoptosis of osteoclasts after application of orthodontic forces to rat teeth

Letizia Penolazzi, Eros Magri, Elisabetta Lambertini, Girolamo Calò, Mauro Cozzani, Giuseppe Siciliani, Roberta Piva, Roberto Gambari
Pages: 807-811
Published online on: 01 November 2006

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Article

Endothelial cells from human cerebral aneurysm and arteriovenous malformation release ET-1 in response to vessel rupture

Elisa Boscolo, Giacomo Pavesi, Paolo Zampieri, Maria Teresa Conconi, Chiara Calore, Renato Scienza, Pier Paolo Parnigotto, Marcella Folin
Pages: 813-819
Published online on: 01 November 2006

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Article

Inflammatory response of esophageal epithelium in combined-type esophagitis in rats: a transcriptome analysis

Yuji Naito, Masaaki Kuroda, Kazuhiko Uchiyama, Katsura Mizushima, Satomi Akagiri, Tomohisa Takagi, Osamu Handa, Satoshi Kokura, Norimasa Yoshida, Hiroshi Ichikawa, Toshikazu Yoshikawa
Pages: 821-828
Published online on: 01 November 2006

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Article

Natural killer T cells ameliorate antibody-induced arthritis in macrophage migration inhibitory factor transgenic mice

Dai Takagi, Kazuya Iwabuchi, Masanori Maeda, Yuji Nakamaru, Yasushi Furuta, Satoshi Fukuda, Luc Van Kaer, Jun Nishihira, Kazunori Onoé
Pages: 829-836
Published online on: 01 November 2006

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Article

Metabolic activity of rat hepatocytes cultured on homologous acellular matrix and transplanted into Gunn rats

Silvia Tomat, Patrizia Burra, Enrico Gringeri, Umberto Cillo, Fiorella Calabrese, Cinzia Giacometti, Paolo Carraro, Carlo Macchi, Gastone G. Nussdorfer, Pier Paolo Parnigotto
Pages: 837-842
Published online on: 01 November 2006

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Article

Genetic factors for obesity

Yoshiji Yamada, Kimihiko Kato, Takashi Kameyama, Kiyoshi Yokoi, Hitoshi Matsuo, Tomonori Segawa, Sachiro Watanabe, Sahoko Ichihara, Hidemi Yoshida, Kei Satoh, Yoshinori Nozawa
Pages: 843-851
Published online on: 01 November 2006

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Article

The mismatch repair gene hPMS2 is mutated in primary breast cancer

Gabriela A. Balogh, Rebecca C. Heulings, Jose Russo
Pages: 853-857
Published online on: 01 November 2006

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Article

Ex vivo HR-MAS MRS of human meningiomas: A comparison with in vivo 1H MR spectra

Vitaliano Tugnoli, Luisa Schenetti, Adele Mucci, Francesca Parenti, Rita Cagnoli, Valeria Righi, Andrea Trinchero, Luca Nocetti, Cristian Toraci, Luciano Mavilla, Gianpaolo Trentini, Elena Zunarelli, M. Raffaella Tosi
Pages: 859-869
Published online on: 01 November 2006

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Article

Genetic risk for atherothrombotic cerebral infarction in individuals stratified by sex or conventional risk factors for atherosclerosis

Sachiyo Yamaguchi, Yoshiji Yamada, Norifumi Metoki, Hidemi Yoshida, Kei Satoh, Sahoko Ichihara, Kimihiko Kato, Takashi Kameyama, Kiyoshi Yokoi, Hitoshi Matsuo, Tomonori Segawa, Sachiro Watanabe, Yoshinori Nozawa
Pages: 871-883
Published online on: 01 November 2006

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Article

Dual regulation of soluble tumor necrosis factor-α induced activation of human monocytic cells via modulating transmembrane TNF-α-mediated ‘reverse signaling’

Lijun Xin, Jing Wang, Hailong Zhang, Wenfang Shi, Mingxia Yu, Qingfen Li, Xiaodan Jiang, Feili Gong, Kevin Gardner, Qingdi Q. Li, Zhuoya Li
Pages: 885-892
Published online on: 01 November 2006

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Article

Suppressive effect of non-anaphylactogenic anti-IgE antibody on the development of dextran sulfate sodium-induced colitis

Ok-Hwa Kang, Dae-Ki Kim, Yeon-A Choi, Hye-Jung Park, Jin Tae, Chon-Sik Kang, Suck-Chei Choi, Yong-Ho Nah, Hern-Ku Lee, Young-Mi Lee
Pages: 893-899
Published online on: 01 November 2006

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Article

Transcriptional targeting of virus-mediated gene transfer by the human hexokinase II promoter

Ann-Marie Määttä, Sanna Korja, Heli Venhoranta, Tanja Hakkarainen, Eija Pirinen, Sami Heikkinen, Riikka Pellinen, Kimmo Mäkinen, Jarmo Wahlfors
Pages: 901-908
Published online on: 01 November 2006

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Article

Enhancement of radiosensitivity by topoisomerase II inhibitor, amrubicin and amrubicinol, in human lung adenocarcinoma A549 cells and kinetics of apoptosis and necrosis induction

Sachiko Hayashi, Masanori Hatashita, Hideki Matsumoto, Hiroki Shioura, Ryuhei Kitai, Eiichi Kano
Pages: 909-915
Published online on: 01 November 2006

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Article

Multiple splicing variants of Naf1/ABIN-1 transcripts and their alterations in hematopoietic tumors

Yasuhiro Shiote, Mamoru Ouchida, Yoshimi Jitsumori, Yoichiro Ogama, Yoshinobu Matsuo, Fumihiko Ishimaru, Mitsune Tanimoto, Kenji Shimizu
Pages: 917-923
Published online on: 01 November 2006

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Article

Functional characterization of histamine receptor subtypes in a human bronchial epithelial cell line

Tobias Müller, Daniel Myrtek, Hannes Bayer, Stephan Sorichter, Katrin Schneider, Gernot Zissel, Johannes Norgauer, Marco Idzko
Pages: 925-931
Published online on: 01 November 2006

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Article

Association of phosphodiesterase 4D gene polymorphisms with chronic obstructive pulmonary disease: Relationship to interleukin 13 gene polymorphism

Shinsuke Homma, Tohru Sakamoto, Ahmed E. Hegab, Wataru Saitoh, Akihiro Nomura, Yukio Ishii, Yuko Morishima, Takashi Iizuka, Takumi Kiwamoto, Yosuke Matsuno, Hosam H. Massoud, Hosny M. Massoud, Khalid M. Hassanein, Kiyohisa Sekizawa
Pages: 933-939
Published online on: 01 November 2006

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Article

Tumour-stroma interactions between metastatic prostate cancer cells and fibroblasts

Annette Kaminski, Jens Claus Hahne, El-Mustapha Haddouti, Alexandra Florin, Axel Wellmann, Nicolas Wernert
Pages: 941-950
Published online on: 01 November 2006

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Article

Neuromedin U receptor 1 expression in the rat endocrine pancreas and evidence suggesting neuromedin U suppressive effect on insulin secretion from isolated rat pancreatic islets

Przemyslaw Kaczmarek, Ludwik K. Malendowicz, Ewa Pruszynska-Oszmalek, Tatiana Wojciechowicz, Dawid Szczepankiewicz, Tomasz Szkudelski, Krzysztof W. Nowak
Pages: 951-955
Published online on: 01 November 2006

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Article

The effects of macrophage migratory inhibitory factor on acute-phase protein production in primary human hepatocytes

Nicholas M. Wheelhouse, Nabil Dowidar, Cornelis H.C. Dejong, O. James Garden, James J. Powell, Matthew D. Barber, Kathryn Sangster, Jean P. Maingay, James A. Ross
Pages: 957-961
Published online on: 01 November 2006

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Article

Expression of the Nd1 gene is down-regulated by doxorubicin at post-transcriptional level

Yasuyuki Takamori, Yuji Matsudo, Lisa Fujimura, Myengmo Kang, Yoshitada Harada, Hideshige Moriya, Takeshi Tokuhisa, Masahiko Hatano
Pages: 963-967
Published online on: 01 November 2006

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Review

Hemostasis alterations in metabolic syndrome (Review)

Iván Palomo, Marcelo Alarcón, Rodrigo Moore-Carrasco, Josep M. Argilés
Pages: 969-974
Published online on: 01 November 2006

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Article

Antiangiogenic activity of a concentrated effective microorganism fermentation extract

Chung Hin Chui, Roberto Gambari, Fung Yi Lau, Desmond Kwok Po Hau, Raymond Siu Ming Wong, Gregory Yin Ming Cheng, Stanton Hon Lung Kok, Teruo Higa, Bin Ke, Albert Sun Chi Chan, David Wan Fun Fong, Johnny Cheuk On Tang
Pages: 975-979
Published online on: 01 November 2006

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Article

Com-1/p8 acts as a putative tumour suppressor in prostate cancer

Wen G. Jiang, Gaynor Davies, Tracey A. Martin, Howard Kynaston, Malcolm D. Mason, Oystein Fodstad
Pages: 981-986
Published online on: 01 November 2006

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Article

Pro-oxidative effects of tea and polyphenols, epigallocatechin-3-gallate and epigallocatechin, on G6PD-deficient erythrocytes in vitro

Chun Hay Ko, Karen Li, Pak Cheung Ng, Kwok Pui Fung, Chung Leung Li, Raymond Pui-On Wong, Kit Man Chui, Goldie Jia-Shi Gu, Edmund Yung, Chi Chiu Wang, Tai Fai Fok
Pages: 987-994
Published online on: 01 November 2006

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Article

Development and evaluation of a colorimetric PCR system for the detection and typing of human papillomaviruses

Diego Chouhy, Lisandro Benítez Gil, Ana L. Nocito, Daniel Wojdyla, Leonardo Ornella, Jorge Cittadini, Daniela Gardiol, Adriana A. Giri
Pages: 995-1003
Published online on: 01 November 2006

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Journal Cover
September-2026 Volume 58 Issue 3

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Journal Metrics

Impact Factor: 8.5

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

Mechanisms and therapeutic strategies of pyroptosis in sepsis‑induced acute lung injury (Review)

Wenyu Wu, Nuoran Li, Guoshu Deng, Suyi Yang, Ruifeng Zeng, Rui Chen, Jun Li
Article Number: 264
Published online on: 22 July 2026

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Review Open Access

Gut‑bone metabolites: SCFAs, polyamines and microbial metabolomics in osteoporosis risk and therapy (Review)

Fuchao Chen, Jingyue Sun, Xiao Wang
Article Number: 263
Published online on: 21 July 2026

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Expression of Concern Open Access

[Expression of Concern] Exposure to acoustic stimuli promotes the development and differentiation of neural stem cells from the cochlear nuclei through the clusterin pathway

Tao Xue, Li Wei, Ding-Jun Zha, Li Qiao, Lian-Jun Lu, Fu-Quan Chen, Jian-Hua Qiu
Article Number: 262
Published online on: 20 July 2026

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Article Open Access

Cepharanthine inhibits tick‑borne encephalitis virus infection through modulation of the stress and inflammation response

Wan-Da Tang, Lan-Juan Zhao
Article Number: 261
Published online on: 16 July 2026

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Article Open Access

circCACNA1D drives pulmonary fibrosis by regulating pyruvate kinase M2 dimer‑tetramer switching

Yujie Wang, Xiaoting Li, Meirong Wang, Nailiang Zhai, Mengqi Jiang, Bo Liu, Changjun Lv, Songzi Zhang, Xiaodong Song, Jinjin Zhang
Article Number: 260
Published online on: 15 July 2026

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Review Open Access

Recent progress and therapeutic strategies in the treatment of cervical neuroendocrine neoplasms (Review)

Yanpeng Tian, Yu Zhang, Liling Wang, Zhongkang Li, Xiaotong Xu, Shouze Liu, Shenyu Yang, Xiangyang Ren, Menghan Xu, Xingzi Chang, Xianghua Huang, Qian Zhao, Ruixia Guo
Article Number: 259
Published online on: 15 July 2026

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Review Open Access

Neurofibromin in bone disease: Mechanisms and therapeutic implications (Review)

Shuhong Zhang, Ge Yang
Article Number: 258
Published online on: 14 July 2026

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Review Open Access

Exercise‑induced exosomal noncoding RNAs: Molecular signaling cascades in bone remodeling and translational applications in sports‑related bone injuries (Review)

Bin Tian, Xuesong Chen, Jiang Zheng, Xin Kang
Article Number: 257
Published online on: 14 July 2026

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Review Open Access

Targeting alveolar type II cell dysfunction in idiopathic pulmonary fibrosis: Molecular mechanisms and emerging therapeutic strategies (Review)

Tianhao Xie, Kang Hu, Shu Pan, Xin Tong, Haitong Huang, Hao Ding, Jun Zhao
Article Number: 256
Published online on: 13 July 2026

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Article Open Access

Tubular PFKFB3 drives diabetic kidney fibrosis via lactate‑dependent H4K12 lactylation and HIPK2 transactivation

Mingkun Xu, Linhang Fu, Yulong Zhang, Xiuli Guo, Han Wu, Sijing Gao, Fei Xiao, Li Xu
Article Number: 255
Published online on: 13 July 2026

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Retraction Open Access

[Retracted] p73 participates in WWOX-mediated apoptosis in leukemia cells

Donghong Lin, Zhaolei Cui, Lingying Kong, Feng Cheng, Jianping Xu, Fenghua Lan
Article Number: 254
Published online on: 13 July 2026

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Article Open Access

Role of hyperthermia in overcoming HPV‑mediated MHC‑Ⅰ downregulation and promoting immune surveillance

Hanyu Wang, Hongxin Lang, Yaoxing Guo, Te Sun, Yuansong Bai, Tao Zhang, Rui-Qun Qi
Article Number: 253
Published online on: 10 July 2026

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Review Open Access

Endocrine‑metabolic imbalance drives osteoarthritis: From whole‑joint pathobiology to precision therapy (Review)

Ruhui Yang, Haimin Zeng, Qi Xiao, Yining Xie, Yi Long, Xiang Chen
Article Number: 252
Published online on: 09 July 2026

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Expression of Concern Open Access

[Expression of Concern] Roles and mechanisms of action of HNF‑4α in the hepatic differentiation of WB‑F344 cells

Yumeng Shi, Dehua Zhou, Bingyi Wang, Deren Zhou, Baomin Shi
Article Number: 251
Published online on: 08 July 2026

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Article Open Access

Phenylalanine exacerbates psoriasiform inflammation through NF‑κB‑mediated dendritic cell activation and Th17 polarization

Yaohan Xu, Jing Pan, Jie Chen, Yutao Zhu, Miaolian Cai, Zeyu Ma, Siji Chen, Tianze Yu, Yushu Wei, Jingying Pan, Kunliang Luo, Yinjing Song, Stijn Van Der Veen, Hao Cheng
Article Number: 250
Published online on: 08 July 2026

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Review Open Access

Protective effects of Astragaloside IV on various liver diseases: From chemistry to herbal medicines (Review)

Jialu Shi, Xiaoyu Zhou, Jiabin Wu, Liru Zeng, Xia Wang, Wei Li, Xiao Huang, Xiaoyu Deng, Wenhong Wang
Article Number: 249
Published online on: 07 July 2026

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GRP78 dysregulation: A proposed molecular mechanism linking the tumor microenvironment to sepsis susceptibility in patients with cancer (Review)

Hang Ruan, Meipeng Zhu, Shi-Yan Liu, Li-Juan Zou, Shu-Sheng Li
Article Number: 248
Published online on: 07 July 2026

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Review Open Access

FGFR1 signaling in rheumatoid arthritis: Mechanisms of bone destruction and therapeutic targeting (Review)

Changzhong Qian, Zhenyu Zhang, Xian Wu, Huibo Ti, Junjie Wu, Zhengdong Yuan, Xia Li, Feng-Lai Yuan
Article Number: 247
Published online on: 06 July 2026

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Retraction Open Access

[Retracted] β‑catenin signaling induces the osteoblastogenic differentiation of human pre‑osteoblastic and bone marrow stromal cells mainly through the upregulation of osterix expression

Bo Liu, Song Wu, Lihua Han, Chaoyue Zhang
Article Number: 246
Published online on: 06 July 2026

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Article Open Access

Single‑cell atlas reveals a Wilms' tumor 1‑mediated axis driving granulosa cell senescence in human ovarian aging

Yanfang Du, Congyu Zhou, Yanpeng Tian, Zhongkang Li, Xianghua Huang
Article Number: 245
Published online on: 03 July 2026

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Review Open Access

TRPV1‑mediated central sensitisation: Core mechanisms of migraine chronification and novel targeted therapeutic strategies (Review)

Mingxia Zhang, Yuting Pu, Yujie Zhang, Jia Hu, Shuangyang Li, Hongmei Tang, Bangjiang Fang, Xue Bai
Article Number: 244
Published online on: 02 July 2026

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Correction Open Access

[Corrigendum] Arginine ADP‑ribosyltransferase 1 promotes angiogenesis in colorectal cancer via the PI3K/Akt pathway

Lian Yang, Ming Xiao, Xian Li, Yi Tang, Ya-Lan Wang
Article Number: 243
Published online on: 02 July 2026

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Review Open Access

Research progress on the chemical and pharmacological effects of Semen Strychni (Review)

Jingxin Mao, Xin Du, Dan Zeng, Xin Luo, Yan Li
Article Number: 242
Published online on: 02 July 2026

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Article Open Access

FLI1 enhances the malignant phenotype of glioma cells and exerts immunomodulatory effects through feedback crosstalk with exonic circRNA FECR1 and interferon‑induced ISG15

Xue Wen, Xiaoyi Gu, Xu Yan, Naifei Chen, Lei Zhou, Hui Li, Andrew R. Hoffman, Wei Li, Ji-Fan Hu, Jiuwei Cui
Article Number: 241
Published online on: 01 July 2026

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Role of ZEB1 in angiogenesis and therapeutic potential (Review)

Ruoxin Ren, Chunxiao Yan, Yao Xiang, Lin Jin, Fang Cheng, Lijun Zhang
Article Number: 240
Published online on: 01 July 2026

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Review Open Access

Endothelial dysfunction: A central mechanism linking autosomal dominant polycystic kidney disease and intracranial aneurysms (Review)

Xiaohong Xu, Ruyi Xu, Liexiang Zhang
Article Number: 239
Published online on: 01 July 2026

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Correction Open Access

[Corrigendum] Effect of SDF‑1/CXCR4 axis on the migration of transplanted bone mesenchymal stem cells mobilized by erythropoietin toward lesion sites following spinal cord injury

Jun Li, Weichun Guo, Min Xiong, Heng Han, Jie Chen, Dan Mao, Bing Tang, Hualong Yu, Yun Zeng
Article Number: 238
Published online on: 01 July 2026

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Review Open Access

Exercise and fluoxetine in Alzheimer's disease: Molecular mechanisms of synergistic and antagonistic effects (Review)

Mei Wu, Yan Li
Article Number: 237
Published online on: 30 June 2026

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Review Open Access

Oral‑gut axis in systemic disease: A barrier‑metabolism‑immunity three‑dimensional regulatory model (Review)

Qing Li, Mingrong Cheng, Weiwei Li, Xiaoyue Wang, Xiaoqing Liu, Yujie Yan
Article Number: 236
Published online on: 30 June 2026

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Review Open Access

ABCG2 transporter: Structural and functional associations with gout (Review)

Muhammad Arslan Asif, Zeshan Zulfiqar, Bahar E. Mustafa, Usman Nazir, Jiamen Sun, Zhichang Wang, Yalei Cui, Sun Hao, Liu Boshuai, Yinghua Shi
Article Number: 235
Published online on: 30 June 2026

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Review Open Access

Neuropilin‑1: Emerging roles in nerve‑vessel‑bone coupling during fracture repair (Review)

Keyue Zhang, Tong Li, Huan Liu, Huibo Ti, Zhenyu Zhang, Zhengdong Yuan, Junjie Wu, Xielin Yan, Zixin Luo, Haiting Hu, Xingchen Yao, Shuwen Shi, Xian Wu, Feng-Lai Yuan, Xiao Chen
Article Number: 234
Published online on: 30 June 2026

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Correction Open Access

[Corrigendum] Crocin exerts anti‑inflammatory and anti‑catabolic effects on rat intervertebral discs by suppressing the activation of JNK

Kang Li, Yan Li, Zhenjiang Ma, Jie Zhao
Article Number: 233
Published online on: 29 June 2026

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Review Open Access

Skeletal muscle‑derived extracellular vesicles in multi‑organ degenerative disease: Mechanisms and therapeutic delivery perspectives (Review)

Xianji Wei, Chengyan Guo, Wei Zhang, Guanyi Wang, Wenjing Li, Binghong Gao, Bo Gao, Lingli Zhang
Article Number: 232
Published online on: 26 June 2026

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October-2026 Volume 58 Issue 4

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Journal Metrics

Impact Factor: 8.5

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

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