Urotensin-II and its receptor (UT-R) are expressed in rat brain endothelial cells, and urotensin-II via UT-R 
stimulates angiogenesis in vivo and in vitro

Spinazzi,Raffaella; Albertin,Giovanna; Nico,Beatrice; Guidolin,Diego; Di Liddo,Rosa; Rossi,Gian Paolo; Ribatti,Domenico; Nussdorfer,Gastone G.

doi:10.3892/ijmm.18.6.1107

December 2006 Volume 18 Issue 6

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December 2006 Volume 18 Issue 6

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Article

Urotensin-II and its receptor (UT-R) are expressed in rat brain endothelial cells, and urotensin-II via UT-R stimulates angiogenesis in vivo and in vitro

Authors:
- Raffaella Spinazzi
- Giovanna Albertin
- Beatrice Nico
- Diego Guidolin
- Rosa Di Liddo
- Gian Paolo Rossi
- Domenico Ribatti
- Gastone G. Nussdorfer
View Affiliations / Copyright

Affiliations: Department of Human Anatomy and Physiology, Section of Anatomy, University of Padua, I-35121 Padua, Italy
Pages: 1107-1112
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Published online on: December 1, 2006

https://doi.org/10.3892/ijmm.18.6.1107
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Abstract

Urotensin-II (UII), along its receptor UT-R, is widely expressed in the cardiovascular system, where it exerts regulatory actions under both physiological and pathological conditions. Real-time PCR and immunocytochemistry demonstrated the expression of UII and UT-R as mRNA and protein in rat neuromicrovascular endothelial cells (NECs). UII did not affect the proliferation rate of cultured NECs, but exerted a strong angiogenic action in both an in vitro assay on Matrigel and an in vivo assay on chorioallantoic membrane. The angiogenic effect of UII was similar to that of FGF-2, and was abolished by the UT-R antagonist Palosuran. Collectively, our findings allow us to include UII in the group of cytokines (e.g. endothelin-1 and adrenomedullin), which are expressed in endothelial cells and exert a pro-angiogenic effect acting in an autocrine-paracrine manner.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Urotensin-II and its receptor (UT-R) are expressed in rat brain endothelial cells, and urotensin-II via UT-R stimulates angiogenesis in vivo and in vitro

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