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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
December 2006 Volume 18 Issue 6

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review

Cytokine actions in growth disorders associated with pediatric chronic inflammatory diseases (Review)

V.E. MacRae, S.C. Wong, C. Farquharson, S.F. Ahmed
Pages: 1011-1018
Published online on: 01 December 2006

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Review

Hedgehog signaling pathway and gastrointestinal stem cell signaling network (Review)

Yuriko Katoh, Masaru Katoh
Pages: 1019-1023
Published online on: 01 December 2006

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Review

Current and future approaches for the therapeutic targeting of metastasis (Review)

Elitza Germanov, Jason N. Berman, Duane L. Guernsey
Pages: 1025-1036
Published online on: 01 December 2006

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Review

Dense-core granules in neuroendocrine cells and neurons release their secretory constituents by piecemeal degranulation (Review)

Enrico Crivellato, Beatrice Nico, Eugenio Bertelli, Gastone G. Nussdorfer, Domenico Ribatti
Pages: 1037-1046
Published online on: 01 December 2006

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Article

Rapid changes in liver lipid composition and pancreatic islet K+ handling and secretory behaviour provoked by the intravenous administration of a medium-chain triglyceride:fish oil emulsion to long-chain polyunsaturated ω3 fatty acid-depleted rats

Karim Louchami, Ying Zhang, Berrin Oguzhan, Christine Delporte, Laurence Portois, Yvon A. Carpentier, Franck Genten, Andre Danguy, Willy J. Malaisse, A. Sener
Pages: 1047-1055
Published online on: 01 December 2006

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Article

Molecular profiles of the mouse postnatal development of the esophageal epithelium showing delayed growth start

Hiroyuki Daiko, Noriyuki Isohata, Masayuki Sano, Kazuhiko Aoyagi, Kenji Ogawa, Shingo Kameoka, Teruhiko Yoshida, Hiroki Sasaki
Pages: 1057-1066
Published online on: 01 December 2006

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Article

Genetic and pathologic characteristics of gastrointestinal stromal tumors in extragastric lesions

Songde Cho, Yasuhiko Kitadai, Shigeto Yoshida, Shinji Tanaka, Masaharu Yoshihara, Kazuhiro Yoshida, Kazuaki Chayama
Pages: 1067-1071
Published online on: 01 December 2006

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Article

Comano's (Trentino) thermal water interferes with interleukin-6 production and secretion and with cytokeratin-16 expression by cultured human psoriatic keratinocytes: Further potential mechanisms of its anti-psoriatic action

Anna Chiarini, Ilaria Dal Pra, Raffaella Pacchiana, Giuseppe Zumiani, Mauro Zanoni, Ubaldo Armato
Pages: 1073-1079
Published online on: 01 December 2006

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Article

DNA topoisomerase IIα (TOP2A) inhibitors up-regulate fatty acid synthase gene expression in SK-Br3 breast cancer cells: In vitro evidence for a ‘functional amplicon’ involving FAS, Her-2/neu and TOP2A genes

Javier A. Menendez, Luciano Vellon, Ruth Lupu
Pages: 1081-1087
Published online on: 01 December 2006

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Article

CD105(+) cells from Wharton's jelly show in vitro and in vivo myogenic differentiative potential

Maria Teresa Conconi, Patrizia Burra, Rosa Di Liddo, Chiara Calore, Michela Turetta, Silvia Bellini, Patrizio Bo, Gastone G. Nussdorfer, Pier Paolo Parnigotto
Pages: 1089-1096
Published online on: 01 December 2006

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Article

Real-time PCR analysis of leptin and leptin receptor expression in the rat prostate, and effects of leptin on prostatic acid phosphatase release

Witold Malendowicz, Marcin Rucinski, Anna S. Belloni, Agnieszka Ziolkowska, Gastone G. Nussdorfer, Zbigniew Kwias
Pages: 1097-1100
Published online on: 01 December 2006

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Article

Expression of neuropeptides B and W and their receptors in endocrine glands of the rat

Anna Hochol, Anna S. Belloni, Marcin Rucinski, Agnieszka Ziolkowska, Rosa Di Liddo, Gastone G. Nussdorfer, Ludwik K. Malendowicz
Pages: 1101-1106
Published online on: 01 December 2006

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Article

Urotensin-II and its receptor (UT-R) are expressed in rat brain endothelial cells, and urotensin-II via UT-R stimulates angiogenesis in vivo and in vitro

Raffaella Spinazzi, Giovanna Albertin, Beatrice Nico, Diego Guidolin, Rosa Di Liddo, Gian Paolo Rossi, Domenico Ribatti, Gastone G. Nussdorfer
Pages: 1107-1112
Published online on: 01 December 2006

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Article

Effects of 7-ketocholesterol on the activity of endothelial poly(ADP-ribose) polymerase and on endothelium-dependent relaxant function

Levente Kiss, Min Chen, Domokos Gero, Katalin Módis, Zsombor Lacza, Csaba Szabó
Pages: 1113-1117
Published online on: 01 December 2006

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Article

Cloning and characterization of a novel sperm tail protein, NYD-SP28

Ying Zheng, Jingjing Zhang, Lei Wang, Zuomin Zhou, Min Xu, Jianmin Li, Jia-hao Sha
Pages: 1119-1125
Published online on: 01 December 2006

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Article

Mitogen stimulation activates different signaling pathways in early- and late-divided T cells as revealed by DNA microarray analysis

Yufeng Li, Kwong-Kwok Wong, Satoko Matsueda, Clay L. Efferson, David Z. Chang, Constantin G. Ioannides, Naotake Tsuda
Pages: 1127-1139
Published online on: 01 December 2006

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Article

Epigallocatechin gallate and genistein attenuate glial fibrillary acidic protein elevation induced by fibrogenic cytokines in hepatic stellate cells

Chunyan Zhang, Lang Zhuo
Pages: 1141-1151
Published online on: 01 December 2006

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Article

Highly frequent allelic loss of chromosome 6q16-23 in osteosarcoma: Involvement of cyclin C in osteosarcoma

Norihide Ohata, Sachio Ito, Aki Yoshida, Toshiyuki Kunisada, Kunihiko Numoto, Yoshimi Jitsumori, Hirotaka Kanzaki, Toshifumi Ozaki, Kenji Shimizu, Mamoru Ouchida
Pages: 1153-1158
Published online on: 01 December 2006

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Article

Promotive effect of Shoyu polysaccharides from soy sauce on iron absorption in animals and humans

Makio Kobayashi, Yuko Nagatani, Norihiro Magishi, Nozomu Tokuriki, Yoshiyuki Nakata, Ryo-Ichi Tsukiyama, Hiromi Imai, Makoto Suzuki, Masami Saito, Keisuke Tsuji
Pages: 1159-1163
Published online on: 01 December 2006

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Article

Endocrine disruptors and rat adrenocortical function: Studies on freshly dispersed and cultured cells

Agnieszka Ziolkowska, Anna S. Belloni, Gastone G. Nussdorfer, Magdalena Nowak, Ludwik K. Malendowicz
Pages: 1165-1168
Published online on: 01 December 2006

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Article

Does the PGC-1/PPARγ pathway play a role in Com-1/p8 mediated cell growth inhibition in prostate cancer?

Wen G. Jiang, Gaynor Davies, Howard Kynaston, Malcolm D. Mason, Oystein Fodstad
Pages: 1169-1175
Published online on: 01 December 2006

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Article

Preclinical investigations of a medium-chain triglyceride:fish oil emulsion III. Experiments in cultured endothelial cells

Yvon A. Carpentier, Isabelle Dupont, Laurence Portois, Willy J. Malaisse
Pages: 1177-1185
Published online on: 01 December 2006

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Article

Phosphorylation of p27(KIP1) in lens epithelial cells after extraction of fiber cells

Satoru Kase, Kazuhiko Yoshida, Xue-Hai Jin, Yoshikazu Koyama, Nobuyoshi Kitaichi, Kazuhiro Ohgami, Kenji Shiratori, Iliyana Ilieva, Shigeaki Ohno
Pages: 1187-1191
Published online on: 01 December 2006

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Article

Regulatory T cells induced by rAAV carrying the forkhead box P3 gene prevent autoimmune thyroiditis in mice

Shengjun Wang, Huaxi Xu, Yongzhong Wang, Jie Ma, Chaoming Mao, Qixiang Shao, Bin Ma, Wenrong Xu, Shengli Yang
Pages: 1193-1199
Published online on: 01 December 2006

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Article

Cell-specific enhancement of liposomal transfection by steroids in steroid receptor expressing cells

Frank Köster, Andreas Schröder, Dominique Finas, Charlotte Hauser, Klaus Diedrich, Ricardo Felberbaum
Pages: 1201-1205
Published online on: 01 December 2006

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Article

Region-specific alterations of global protein expression in the remodelled rat myocardium

Christian Melle, Juan A. Camacho, Ralf Surber, Stefan Betge, Ferdinand Von Eggeling, Thomas Zimmer
Pages: 1207-1215
Published online on: 01 December 2006

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Article

Apoptogenic activity of a synthetic cantharimide in leukaemia: Implication on its structural activity relationship

Stanton Hon Lung Kok, Chung Hin Chui, Wing Sze Lam, Jien Chen, Fung Yi Lau, Raymund Siu Ming Wong, Gregory Yin Ming Cheng, Wing Ka Tang, Ivy Tuang Ngo Teo, Filly Cheung, Chor Hing Cheng, Albert Sun Chi Chan, Johnny Cheuk On Tang
Pages: 1217-1221
Published online on: 01 December 2006

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Article

Uncoupling protein 3 expression and intramyocellular lipid accumulation by NMR following local burn trauma

Qunhao Zhang, Haihui Cao, Loukas G. Astrakas, Dionyssios Mintzopoulos, Michael N. Mindrinos, John Schulz, Ronald G. Tompkins, Laurence G. Rahme, A. Aria Tzika
Pages: 1223-1229
Published online on: 01 December 2006

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Article

Fatty acid content and pattern of epididymal and parametrial adipose tissue lipids in streptozotocin (type 1) and Goto-Kakizaki (type 2) diabetic rats

Willy J. Malaisse, Laurence Portois, Ying Zhang, Berrin Oguzhan, Karim Louchami, Hassan Jijakli, Philippe Courtois, Abdullah Sener, Yvon A. Carpentier
Pages: 1231-1234
Published online on: 01 December 2006

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Journal Cover
March-2026 Volume 57 Issue 3

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Article Open Access

Ginkgolide C alleviates atherosclerosis via activating Nrf2 to inhibit ROS‑dependent NLRP3 inflammasome activation

Rui Zhang
Article Number: 75
Published online on: 27 January 2026

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Review Open Access

MicroRNA‑microbiome cross‑kingdom networks drive inflammatory bowel disease through dynamic regulatory ecosystems (Review)

Liping Liang, Xiaoyan Liu, Bang Li, Huyi Lei, Zibo Tang, Shijie Mai, Chenghai Yang, Yongjian Zhou, Shaoheng Zhang, Le Liu
Article Number: 74
Published online on: 27 January 2026

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Review Open Access

Mechanistic insights into pancreatic cancer progression from circadian rhythm disruption and gut microbiota dysbiosis (Review)

Yang Liu, Yongfeng Li, Heng Ma, Shichang Deng, Chao Cheng
Article Number: 73
Published online on: 26 January 2026

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Retraction Open Access

[Retracted] miR‑124‑3p inhibits the viability and motility of glioblastoma multiforme by targeting RhoG  

Shan Cai, Chao-Jia Shi, Jian-Xiang Lu, Yan-Pei Wang, Tian Yuan, Xiang-Peng Wang
Article Number: 72
Published online on: 26 January 2026

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Review Open Access

Natural products as multi‑target therapies for sepsis‑induced myocardial dysfunction (Review)

Fei Tang, Dong Liu, Shi-Chao Zhu, Hui-Min Zhou, Xue-Wen Qiu
Article Number: 71
Published online on: 22 January 2026

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Review Open Access

MTHFR‑folate axis as a modulator of the epigenetic landscape in autoimmune diseases (Review)

Pablo Michael Navarro‑Rodríguez, Ramón Francisco Bajeca‑Serrano, Francisco Javier Turrubiates‑Hernández, Hazael Ramiro Ceja‑Gálvez, Jorge Hernández‑Bello, Cristian Oswaldo Hernández‑Ramírez, Saúl Ramírez‑de Los Santos, José Francisco Muñoz‑Valle
Article Number: 70
Published online on: 22 January 2026

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Article Open Access

Natural compound 5,7,8‑trimethoxyflavone mitigates radiation‑induced lung injury by suppressing EMT and PI3K/Akt pathway

Cui-Cui Gong, Hua-Kang Li, Yuan-Zhen Mi, Jun-Yang Chen, Zeng-Yi Fang, Shun-Lian Fu, Li Quan, Bing Lin, Jin-Yi Lang, Qiu Chen, Ke Xu, Mei-Hua Chen
Article Number: 69
Published online on: 21 January 2026

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Review Open Access

Epigenetic dysregulation of B‑cells in autoimmune diseases and lymphomas (Review)

Yuxing Li, Yujiao Gong, Jiaxing Zhao, Rensen Ran
Article Number: 68
Published online on: 21 January 2026

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Review Open Access

Research progress on the effects of macrophage‑derived exosomes on muscle factors IGF‑1 and FGF‑2 mediating musculoskeletal crosstalk molecular signaling pathway on bone metabolism (Review)

Ruo-Mei Cui, Mai Zheng, Jian-Bin Hong, Zheng-Xiang Wang, Yu-Fang Cun, Shu-Ji Gao, Yan-Lin Zhu, Zi-Bin Yang, Ming-Wei Liu
Article Number: 67
Published online on: 21 January 2026

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Expression of Concern Open Access

[Expression of Concern] Long non‑coding RNA SNHG20 promotes bladder cancer via activating the Wnt/β‑catenin signalling pathway

Qingsong Zhao, Saiyue Gao, Qingyan Du, Ye Liu
Article Number: 66
Published online on: 21 January 2026

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Review Open Access

Mangiferin in human disease: Multifaceted mechanisms and applications (Review)

Yaling Dai, Qiuling Huang, Mengquan Tan, Zhifu Wang, Cai Jiang, Zheng Liu, Shenghang Zhang, Siyuan Song
Article Number: 65
Published online on: 21 January 2026

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Article

Deciphering the CAF‑LCN2 axis: Key to overcoming anti‑PD‑L1 immunotherapy resistance in lung cancer

Dan Xiao, Jing Yang, Jianying Zhou, Zhenzhen Hu, Ting Zhang
Article Number: 64
Published online on: 19 January 2026

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Retraction Open Access

[Retracted] DDAH2 alleviates myocardial fibrosis in diabetic cardiomyopathy through activation of the DDAH/ADMA/NOS/NO pathway in rats

Zhen-Dong Zhu, Ji-Ming Ye, Xue-Mei Fu, Xue-Chang Wang, Ji-Yun Ye, Xin-Ran Wu, Peng Hua, Yu-Qiong Liao, Wei Xuan, Jin-Lan Duan, Wei-Yuan Li, Hui Fu, Zhong-Hua Xia, Xuan Zhang
Article Number: 63
Published online on: 19 January 2026

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Review Open Access

Beyond hepatic stellate cell heterogeneity: Resolving fibrosis, restoring regeneration (Review)

Chang Gao, Guiqing Chen, Hongyan Jia, Hong Zhu, Yun Cai, Dakai Yang, Kai Zhao
Article Number: 62
Published online on: 14 January 2026

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Correction Open Access

[Corrigendum] CDKN2A (p16INK4A) affects the anti‑tumor effect of CDK inhibitor in somatotroph adenomas

Yiyuan Chen, Zhenye Li, Qiuyue Fang, Hongyun Wang, Chuzhong Li, Hua Gao, Yazhuo Zhang
Article Number: 61
Published online on: 14 January 2026

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Review Open Access

Harnessing MSC‑derived exosomes to modulate the pathophysiology of ASD: Recent advances and therapeutic implications (Review)

Zhaojian Sun, Nouman Amjad, Majid Muhammad, Zhiyuan Li
Article Number: 60
Published online on: 13 January 2026

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Retraction Open Access

[Retracted] Mechanism of cell death induced by silica nanoparticles in hepatocyte cells is by apoptosis

Ye Yang, Xinjing Du, Qiang Wang, Jianwei Liu, Enguo Zhang, Linlin Sai, Cheng Peng, Martin F. Lavin, Abrey Jie Yeo, Xu Yang, Hua Shao, Zhongjun Du
Article Number: 59
Published online on: 12 January 2026

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Review Open Access

ZG16B: A key regulator of tumor progression and immune microenvironment modulation in cancer (Review)

Xing-Ming Chen, Yu-Bo Liang, Jin-Xiang Zuo, Zi-Sheng Yang, Le-Yu Zhang, Xin-Yu Zhang, Ping Wan, Yang Ke
Article Number: 58
Published online on: 09 January 2026

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Retraction Open Access

[Retracted] Silica nanoparticles induce cardiomyocyte apoptosis via the mitochondrial pathway in rats following intratracheal instillation

Zhongjun Du, Shangya Chen, Guanqun Cui, Ye Yang, Enguo Zhang, Qiang Wang, Martin F. Lavin, Abrey J. Yeo, Cunxiang Bo, Yu Zhang, Chao Li, Xiaoshan Liu, Xu Yang, Cheng Peng, Hua Shao
Article Number: 57
Published online on: 05 January 2026

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Role of cuproptosis in digestive system tumors (Review)

Li Zhang, Yongpeng Cheng, Lulu Tang, Jiaxing Zhu, Biguang Tuo
Article Number: 56
Published online on: 02 January 2026

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Environmental exposure to air pollution and climate: Intersecting the impact on ear and nose health and chemosensory function (Review)

Yu-Chen Zhang, Lei Zhang, Ping-Ting Zhou, Zi-Hui Xie, Wen-Jie Zhang, Min Fan, Yan-Xun Han, Ye-Hai Liu, Yu-Chen Liu
Article Number: 55
Published online on: 31 December 2025

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Role and mechanisms of ferroptosis in cognitive impairment: From molecular pathways to therapeutic targets (Review)

Shenghui Ge, Deyue Kong, Shuyue Fan, Yi Luo, Xiao Yin, Zehua Jin, Wenqing Xia, Jianhua Ma
Article Number: 54
Published online on: 30 December 2025

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The GPR124‑Wnt‑PPARγ regulatory axis: Molecular mechanisms and therapeutic implications in chronic inflammatory diseases (Review)

Ming-Wang Cui, Si-Yu Tao, Tao Wen, Zhu-Ling Guo
Article Number: 53
Published online on: 30 December 2025

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Advances in RPGR gene therapy for X‑linked retinitis pigmentosa: From preclinical insights to clinical application (Review)

Yushan Long, Jia Qi, Wenliang Zhang, Huan Qin, Kai Yao
Article Number: 52
Published online on: 30 December 2025

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Journal Cover
April-2026 Volume 57 Issue 4

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

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