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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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December 2006 Volume 18 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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December 2006 Volume 18 Issue 6

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Article

Regulatory T cells induced by rAAV carrying the forkhead box P3 gene prevent autoimmune thyroiditis in mice

  • Authors:
    • Shengjun Wang
    • Huaxi Xu
    • Yongzhong Wang
    • Jie Ma
    • Chaoming Mao
    • Qixiang Shao
    • Bin Ma
    • Wenrong Xu
    • Shengli Yang

  • View Affiliations / Copyright

    Affiliations: Department of Immunology, School of Medical Technology, Jiangsu University, Jiangsu 12001, P.R. China. sjwjs@ujs.edu.cn
  • Pages: 1193-1199
    |
    Published online on: December 1, 2006
       https://doi.org/10.3892/ijmm.18.6.1193
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Abstract

CD4+CD25+ regulatory T (Treg) cells are immunosuppressive and help maintain peripheral immune tolerance. The forkhead/winged helix family member, Foxp3, has been shown to be a critical regulator of CD4+CD25+ Treg cells. We demonstrate by quantitative real-time PCR that CD4+CD25+ T cells express higher levels of Foxp3 mRNA than other T cell populations. Recombinant adeno-associated virus vector carrying mouse Foxp3 gene under the control of the CMV promoter was generated and used to transduce CD4+CD25− T cells. These Foxp3-transduced T cells are similar to naturally occurring CD4+CD25+ regulatory T cells which show anergy and immunosuppressive activity in vitro. Furthermore, these Foxp3-transduced T cells prevent autoimmune thyroiditis transferred by pathogenic T cells in vivo. Our data indicates that Foxp3-transduced CD4+CD25− T cells may open new therapeutic strategies for immune disorders.

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Copy and paste a formatted citation
Spandidos Publications style
Wang S, Xu H, Wang Y, Ma J, Mao C, Shao Q, Ma B, Xu W and Yang S: Regulatory T cells induced by rAAV carrying the forkhead box P3 gene prevent autoimmune thyroiditis in mice. Int J Mol Med 18: 1193-1199, 2006.
APA
Wang, S., Xu, H., Wang, Y., Ma, J., Mao, C., Shao, Q. ... Yang, S. (2006). Regulatory T cells induced by rAAV carrying the forkhead box P3 gene prevent autoimmune thyroiditis in mice. International Journal of Molecular Medicine, 18, 1193-1199. https://doi.org/10.3892/ijmm.18.6.1193
MLA
Wang, S., Xu, H., Wang, Y., Ma, J., Mao, C., Shao, Q., Ma, B., Xu, W., Yang, S."Regulatory T cells induced by rAAV carrying the forkhead box P3 gene prevent autoimmune thyroiditis in mice". International Journal of Molecular Medicine 18.6 (2006): 1193-1199.
Chicago
Wang, S., Xu, H., Wang, Y., Ma, J., Mao, C., Shao, Q., Ma, B., Xu, W., Yang, S."Regulatory T cells induced by rAAV carrying the forkhead box P3 gene prevent autoimmune thyroiditis in mice". International Journal of Molecular Medicine 18, no. 6 (2006): 1193-1199. https://doi.org/10.3892/ijmm.18.6.1193
Copy and paste a formatted citation
x
Spandidos Publications style
Wang S, Xu H, Wang Y, Ma J, Mao C, Shao Q, Ma B, Xu W and Yang S: Regulatory T cells induced by rAAV carrying the forkhead box P3 gene prevent autoimmune thyroiditis in mice. Int J Mol Med 18: 1193-1199, 2006.
APA
Wang, S., Xu, H., Wang, Y., Ma, J., Mao, C., Shao, Q. ... Yang, S. (2006). Regulatory T cells induced by rAAV carrying the forkhead box P3 gene prevent autoimmune thyroiditis in mice. International Journal of Molecular Medicine, 18, 1193-1199. https://doi.org/10.3892/ijmm.18.6.1193
MLA
Wang, S., Xu, H., Wang, Y., Ma, J., Mao, C., Shao, Q., Ma, B., Xu, W., Yang, S."Regulatory T cells induced by rAAV carrying the forkhead box P3 gene prevent autoimmune thyroiditis in mice". International Journal of Molecular Medicine 18.6 (2006): 1193-1199.
Chicago
Wang, S., Xu, H., Wang, Y., Ma, J., Mao, C., Shao, Q., Ma, B., Xu, W., Yang, S."Regulatory T cells induced by rAAV carrying the forkhead box P3 gene prevent autoimmune thyroiditis in mice". International Journal of Molecular Medicine 18, no. 6 (2006): 1193-1199. https://doi.org/10.3892/ijmm.18.6.1193
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