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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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March 2007 Volume 19 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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March 2007 Volume 19 Issue 3

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Article

Expression of aquaporin-1 in endometrial blood vessels in menorrhagia

  • Authors:
    • Miriam Mints
    • Anna Hildenbrand
    • Luther Parameswaran Grace Lalitkumar
    • Sonia Andersson
    • Sören Nielsen
    • Kristina Gemzell-Danielsson
    • Anneli Stavreus-Evers
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Karolinska University Hospital Huddinge, Karolinska Institutet, S-14186 Stockholm, Sweden. miriam.mints@telia.com
  • Pages: 407-411
    |
    Published online on: March 1, 2007
       https://doi.org/10.3892/ijmm.19.3.407
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Abstract

Aquaporin-1 (AQP1) is a water channel protein expressed in vascular endothelia and involved in impaired angiogenesis in tumors. Since angiogenesis is an essential component of the regeneration of the endometrium, we sought to analyze the expression of AQP1 in endometrial blood vessels in normal cyclic endometrium as well as in endometrial biopsies of menorrhagia patients. Endometrial biopsies from 16 patients with menorrhagia and 21 healthy fertile women were used for immunohistochemistry assessment of AQP1-stained endothelial structures. RT-PCR was used to confirm the presence of AQP1 mRNA. We detected the expression of AQP1 solely in endometrial blood vessels in the control group, as well as in menorrhagic endometrium. There was no difference between proliferative and secretory endometrium. Furthermore, we observed that the vascular expression of AQP1 in endometrial blood vessels in the menorrhagia group was significantly lower than in controls (p=0.002). There was also a significantly lower number of stained vessels per unit area in the menorrhagia group than in the controls (p=0.006). Thus, the deregulation of aquaporin-1 in menorrhagia may be involved in abnormal endometrial vascular growth and permeability.

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Copy and paste a formatted citation
Spandidos Publications style
Mints M, Hildenbrand A, Lalitkumar LP, Andersson S, Nielsen S, Gemzell-Danielsson K and Stavreus-Evers A: Expression of aquaporin-1 in endometrial blood vessels in menorrhagia. Int J Mol Med 19: 407-411, 2007.
APA
Mints, M., Hildenbrand, A., Lalitkumar, L.P., Andersson, S., Nielsen, S., Gemzell-Danielsson, K., & Stavreus-Evers, A. (2007). Expression of aquaporin-1 in endometrial blood vessels in menorrhagia. International Journal of Molecular Medicine, 19, 407-411. https://doi.org/10.3892/ijmm.19.3.407
MLA
Mints, M., Hildenbrand, A., Lalitkumar, L. P., Andersson, S., Nielsen, S., Gemzell-Danielsson, K., Stavreus-Evers, A."Expression of aquaporin-1 in endometrial blood vessels in menorrhagia". International Journal of Molecular Medicine 19.3 (2007): 407-411.
Chicago
Mints, M., Hildenbrand, A., Lalitkumar, L. P., Andersson, S., Nielsen, S., Gemzell-Danielsson, K., Stavreus-Evers, A."Expression of aquaporin-1 in endometrial blood vessels in menorrhagia". International Journal of Molecular Medicine 19, no. 3 (2007): 407-411. https://doi.org/10.3892/ijmm.19.3.407
Copy and paste a formatted citation
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Spandidos Publications style
Mints M, Hildenbrand A, Lalitkumar LP, Andersson S, Nielsen S, Gemzell-Danielsson K and Stavreus-Evers A: Expression of aquaporin-1 in endometrial blood vessels in menorrhagia. Int J Mol Med 19: 407-411, 2007.
APA
Mints, M., Hildenbrand, A., Lalitkumar, L.P., Andersson, S., Nielsen, S., Gemzell-Danielsson, K., & Stavreus-Evers, A. (2007). Expression of aquaporin-1 in endometrial blood vessels in menorrhagia. International Journal of Molecular Medicine, 19, 407-411. https://doi.org/10.3892/ijmm.19.3.407
MLA
Mints, M., Hildenbrand, A., Lalitkumar, L. P., Andersson, S., Nielsen, S., Gemzell-Danielsson, K., Stavreus-Evers, A."Expression of aquaporin-1 in endometrial blood vessels in menorrhagia". International Journal of Molecular Medicine 19.3 (2007): 407-411.
Chicago
Mints, M., Hildenbrand, A., Lalitkumar, L. P., Andersson, S., Nielsen, S., Gemzell-Danielsson, K., Stavreus-Evers, A."Expression of aquaporin-1 in endometrial blood vessels in menorrhagia". International Journal of Molecular Medicine 19, no. 3 (2007): 407-411. https://doi.org/10.3892/ijmm.19.3.407
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