Fatty acid content and pattern of spleen phospholipids and triglycerides in normal and either type-1 or type-2 diabetic rats

Portois,Laurence; Sener,Abdullah; Carpentier,Yvon A.; Malaisse,Willy J.

doi:10.3892/ijmm.19.3.523

March 2007 Volume 19 Issue 3

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March 2007 Volume 19 Issue 3

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Article

Fatty acid content and pattern of spleen phospholipids and triglycerides in normal and either type-1 or type-2 diabetic rats

Authors:
- Laurence Portois
- Abdullah Sener
- Yvon A. Carpentier
- Willy J. Malaisse
View Affiliations / Copyright

Affiliations: Laboratory of Experimental Surgery, Brussels Free University, B-1070 Brussels, Belgium
Pages: 523-528
|
Published online on: March 1, 2007

https://doi.org/10.3892/ijmm.19.3.523
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Abstract

The fatty acid pattern of spleen phospholipids and triglycerides was examined in fed or overnight fasted normal rats, streptozotocin-induced diabetic animals (type-1 diabetes) and Goto-Kakizaki rats (type-2 diabetes). In both phospholipids and triglycerides, differences were observed in the relative contribution of several fatty acids, as well as in the ratio between distinct fatty acids, when comparing fed to fasted rats, normal to diabetic animals and male to female Goto-Kakizaki rats. Diabetes increased to a greater extent the C22:6ω3 content of phospholipids in the spleen than in either the liver or the brain. However, the diabetes-induced changes in the C22:6ω3 content of triglycerides was closely comparable in the spleen, liver and brain. These findings suggest that the incorporation of fatty acids into triglycerides is controlled by comparable regulatory factor(s), e.g. insulinemia, in the spleen, liver and brain. In the case of phospholipids, however, an apparent adaptation to diabetic stress was more marked in the spleen than in the liver, and virtually absent in the brain. The proposed dichotomy in the environmental regulation of fatty acid synthesis and incorporation into phospholipids and triglycerides was further supported by distinct diabetes-related changes in the apparent activity of Δ9-desaturase in these two classes of lipids.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Fatty acid content and pattern of spleen phospholipids and triglycerides in normal and either type-1 or type-2 diabetic rats

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Abstract

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