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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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May 2007 Volume 19 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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May 2007 Volume 19 Issue 5

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Article

Toll-like receptor 3 ligand-induced antiviral response in mouse osteoblastic cells

  • Authors:
    • Kimiya Nakamura
    • Yoshiaki Deyama
    • Yoshitaka Yoshimura
    • Kuniaki Suzuki
    • Manabu Morita

  • View Affiliations / Copyright

    Affiliations: Department of Preventive Dentistry, Division of Oral Health Science, Hokkaido University Graduate School of Dental Medicine, Sapporo 060-8586, Japan
  • Pages: 771-775
    |
    Published online on: May 1, 2007
       https://doi.org/10.3892/ijmm.19.5.771
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Abstract

Double-stranded RNA (dsRNA) and its mimic, polyinosinic acid:polycytidylic acid [poly(I):poly(C)], are recognized by toll-like receptor 3 (TLR3) that induces the production of IFN-β in many cell types. In the present study, we investigated the effects of poly(I):poly(C) on mouse osteoblastic MC3T3-E1 (E1) cells. Poly(I):poly(C) markedly increased IFN-β mRNA level in a dose-dependent manner. The increase in the IFN-β mRNA level was apparent as early as 1 h after adding poly(I):poly(C) to the culture and peaked at 12 h. Stimulation with poly(I):poly(C) enhanced the expression of CXCL10 mRNA and TLR3 in E1 cells. Moreover, poly(I):poly(C) induced tyrosine phosphorylation of the transcription factor STAT1 in E1 cells. An anti-IFN-β neutralizing antibody partially inhibited poly(I):poly(C)-induced CXCL10 mRNA, TLR3 mRNA and STAT1 phosphorylation. These results indicate that osteoblasts secrete IFN-β in response to viral infection and that endogenous IFN-β induces both CXCL10 and TLR3 production via an IFN-α/β receptor-STAT1 pathway. It is suggested that osteoblasts are involved in host defense as well as bone metabolism.

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Copy and paste a formatted citation
Spandidos Publications style
Nakamura K, Deyama Y, Yoshimura Y, Suzuki K and Morita M: Toll-like receptor 3 ligand-induced antiviral response in mouse osteoblastic cells. Int J Mol Med 19: 771-775, 2007.
APA
Nakamura, K., Deyama, Y., Yoshimura, Y., Suzuki, K., & Morita, M. (2007). Toll-like receptor 3 ligand-induced antiviral response in mouse osteoblastic cells. International Journal of Molecular Medicine, 19, 771-775. https://doi.org/10.3892/ijmm.19.5.771
MLA
Nakamura, K., Deyama, Y., Yoshimura, Y., Suzuki, K., Morita, M."Toll-like receptor 3 ligand-induced antiviral response in mouse osteoblastic cells". International Journal of Molecular Medicine 19.5 (2007): 771-775.
Chicago
Nakamura, K., Deyama, Y., Yoshimura, Y., Suzuki, K., Morita, M."Toll-like receptor 3 ligand-induced antiviral response in mouse osteoblastic cells". International Journal of Molecular Medicine 19, no. 5 (2007): 771-775. https://doi.org/10.3892/ijmm.19.5.771
Copy and paste a formatted citation
x
Spandidos Publications style
Nakamura K, Deyama Y, Yoshimura Y, Suzuki K and Morita M: Toll-like receptor 3 ligand-induced antiviral response in mouse osteoblastic cells. Int J Mol Med 19: 771-775, 2007.
APA
Nakamura, K., Deyama, Y., Yoshimura, Y., Suzuki, K., & Morita, M. (2007). Toll-like receptor 3 ligand-induced antiviral response in mouse osteoblastic cells. International Journal of Molecular Medicine, 19, 771-775. https://doi.org/10.3892/ijmm.19.5.771
MLA
Nakamura, K., Deyama, Y., Yoshimura, Y., Suzuki, K., Morita, M."Toll-like receptor 3 ligand-induced antiviral response in mouse osteoblastic cells". International Journal of Molecular Medicine 19.5 (2007): 771-775.
Chicago
Nakamura, K., Deyama, Y., Yoshimura, Y., Suzuki, K., Morita, M."Toll-like receptor 3 ligand-induced antiviral response in mouse osteoblastic cells". International Journal of Molecular Medicine 19, no. 5 (2007): 771-775. https://doi.org/10.3892/ijmm.19.5.771
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