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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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June 2007 Volume 19 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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June 2007 Volume 19 Issue 6

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Article

The Patched gene is epigenetically regulated in ovarian dermoids and fibromas, but not in basocellular carcinomas

  • Authors:
    • Maja Cretnik
    • Vesna Musani
    • Slavko Oreskovic
    • Dinko Leovic
    • Sonja Levanat

  • View Affiliations / Copyright

    Affiliations: Division of Molecular Medicine, Rudjer Boskovic Institute, HR 10002 Zagreb, Croatia
  • Pages: 875-883
    |
    Published online on: June 1, 2007
       https://doi.org/10.3892/ijmm.19.6.875
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Abstract

The Hedgehog/Patched signaling pathway plays a prominent role during mammalian development but it is also involved in oncogenic transformation. We investigated the methylation status of the Patched promotor in a set of basocellular carcinomas of the skin and ovarian tumors as an alternative to mutational causes of the pathway deregulation. Our aim was to define a possible role of genetic and/or epigenetic mechanisms of Hedgehog/Patched signal transduction in the development of these tumors. Bisulfite-converted DNA from tumors and from matched healthy tissue was amplified by a specific PCR and the CpG-rich regions of the Patched promoter were sequenced. Two promoter regions showed statistically significant hypermethylation compared to healthy controls in ovarian tumors; more significantly in the region in the vicinity of Gli1-binding sites and less significantly in the region containing the ATG codon. But, in basocellular carcinomas of the skin we observed no difference in methylation, suggesting different mechanisms of neoplasia in these tumors.

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Copy and paste a formatted citation
Spandidos Publications style
Cretnik M, Musani V, Oreskovic S, Leovic D and Levanat S: The Patched gene is epigenetically regulated in ovarian dermoids and fibromas, but not in basocellular carcinomas. Int J Mol Med 19: 875-883, 2007.
APA
Cretnik, M., Musani, V., Oreskovic, S., Leovic, D., & Levanat, S. (2007). The Patched gene is epigenetically regulated in ovarian dermoids and fibromas, but not in basocellular carcinomas. International Journal of Molecular Medicine, 19, 875-883. https://doi.org/10.3892/ijmm.19.6.875
MLA
Cretnik, M., Musani, V., Oreskovic, S., Leovic, D., Levanat, S."The Patched gene is epigenetically regulated in ovarian dermoids and fibromas, but not in basocellular carcinomas". International Journal of Molecular Medicine 19.6 (2007): 875-883.
Chicago
Cretnik, M., Musani, V., Oreskovic, S., Leovic, D., Levanat, S."The Patched gene is epigenetically regulated in ovarian dermoids and fibromas, but not in basocellular carcinomas". International Journal of Molecular Medicine 19, no. 6 (2007): 875-883. https://doi.org/10.3892/ijmm.19.6.875
Copy and paste a formatted citation
x
Spandidos Publications style
Cretnik M, Musani V, Oreskovic S, Leovic D and Levanat S: The Patched gene is epigenetically regulated in ovarian dermoids and fibromas, but not in basocellular carcinomas. Int J Mol Med 19: 875-883, 2007.
APA
Cretnik, M., Musani, V., Oreskovic, S., Leovic, D., & Levanat, S. (2007). The Patched gene is epigenetically regulated in ovarian dermoids and fibromas, but not in basocellular carcinomas. International Journal of Molecular Medicine, 19, 875-883. https://doi.org/10.3892/ijmm.19.6.875
MLA
Cretnik, M., Musani, V., Oreskovic, S., Leovic, D., Levanat, S."The Patched gene is epigenetically regulated in ovarian dermoids and fibromas, but not in basocellular carcinomas". International Journal of Molecular Medicine 19.6 (2007): 875-883.
Chicago
Cretnik, M., Musani, V., Oreskovic, S., Leovic, D., Levanat, S."The Patched gene is epigenetically regulated in ovarian dermoids and fibromas, but not in basocellular carcinomas". International Journal of Molecular Medicine 19, no. 6 (2007): 875-883. https://doi.org/10.3892/ijmm.19.6.875
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