DJ-1 degrades transthyretin and an inactive form of DJ-1 is secreted in familial amyloidotic polyneuropathy

  • Authors:
    • Shizuyo Koide-Yoshida
    • Takeshi Niki
    • Mitsuharu Ueda
    • Shingo Himeno
    • Takahiro Taira
    • Sanae M.M. Iguchi-Ariga
    • Yukio Ando
    • Hiroyoshi Ariga
  • View Affiliations

  • Published online on: June 1, 2007     https://doi.org/10.3892/ijmm.19.6.885
  • Pages: 885-893
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Abstract

DJ-1 plays roles in transcriptional regulation and anti-oxidative stress, and loss of its function is thought to result in the onset of Parkinson's disease. DJ-1 has a protease-like structure and transthyretin (TTR), a protein causing familial amyloidotic polyneuropathy (FAP), was identified as a substrate for DJ-1 protease in this study. Both TTR and DJ-1 were secreted into the culture medium under normal conditions, and secreted TTR was not aggregated. Under oxidative conditions, TTR but not DJ-1 was secreted into the culture medium, resulting in aggregation. Mirror images of both the expression patterns and solubility of DJ-1 and TTR were observed in tissues of FAP patients, and an unoxidized form of DJ-1, an inactive form, was secreted into the serum of FAP patients. These results suggest that oxidative stress to cells abrogates secretion of DJ-1 and that secreted DJ-1 degrades aggregated TTR to protect against the onset of FAP.

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June 2007
Volume 19 Issue 6

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Koide-Yoshida S, Niki T, Ueda M, Himeno S, Taira T, Iguchi-Ariga SM, Ando Y and Ariga H: DJ-1 degrades transthyretin and an inactive form of DJ-1 is secreted in familial amyloidotic polyneuropathy. Int J Mol Med 19: 885-893, 2007
APA
Koide-Yoshida, S., Niki, T., Ueda, M., Himeno, S., Taira, T., Iguchi-Ariga, S.M. ... Ariga, H. (2007). DJ-1 degrades transthyretin and an inactive form of DJ-1 is secreted in familial amyloidotic polyneuropathy. International Journal of Molecular Medicine, 19, 885-893. https://doi.org/10.3892/ijmm.19.6.885
MLA
Koide-Yoshida, S., Niki, T., Ueda, M., Himeno, S., Taira, T., Iguchi-Ariga, S. M., Ando, Y., Ariga, H."DJ-1 degrades transthyretin and an inactive form of DJ-1 is secreted in familial amyloidotic polyneuropathy". International Journal of Molecular Medicine 19.6 (2007): 885-893.
Chicago
Koide-Yoshida, S., Niki, T., Ueda, M., Himeno, S., Taira, T., Iguchi-Ariga, S. M., Ando, Y., Ariga, H."DJ-1 degrades transthyretin and an inactive form of DJ-1 is secreted in familial amyloidotic polyneuropathy". International Journal of Molecular Medicine 19, no. 6 (2007): 885-893. https://doi.org/10.3892/ijmm.19.6.885