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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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June 2007 Volume 19 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

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Article

Inhibition of poly(adenosine diphosphate-ribose) polymerase by the active form of vitamin D

  • Authors:
    • Jon G. Mabley
    • Rebecca Wallace
    • Pál Pacher
    • Kanneganti Murphy
    • Csaba Szabó

  • View Affiliations / Copyright

    Affiliations: School of Pharmacy and Biomolecular Sciences, University of Brighton, Brighton BN2 4GJ, UK. j.g.mabley@brighton.ac.uk
  • Pages: 947-952
    |
    Published online on: June 1, 2007
       https://doi.org/10.3892/ijmm.19.6.947
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Abstract

Vitamin D is well characterized for its role in mineral homeostasis and maintenance of normal skeletal architecture. Vitamin D has been demonstrated to exert anti-inflammatory effects in a variety of disease states including diabetes, arthritis and inflammatory bowel disease. In these diseases poly[adenosine diphosphate (ADP)-ribose] polymerase (PARP) inhibitors have also proved effective as anti-inflammatory agents. Here we present data demonstrating that the active metabolite of vitamin D, 1α,25-dihydroxy-vitamin D3, is a PARP inhibitor. UV irradiation-mediated PARP activation in human keratinocytes can be inhibited by treatment with vitamin D, 7-dehydrocholesterol or 1α,25-dihydroxyvitamin D3. Inhibition of cytochrome P450 reversed the PARP inhibitory action of vitamin D and 7-dehydrocholesterol, indicating that conversion to 1α,25-dihydroxyvitamin D3 mediates their PARP inhibitory action. Vitamin D may protect keratinocytes against over-activation of PARP resulting from exposure to sunlight. PARP inhibition may contribute to the pharmacological and anti-inflammatory effects of vitamin D.

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Copy and paste a formatted citation
Spandidos Publications style
Mabley JG, Wallace R, Pacher P, Murphy K and Szabó C: Inhibition of poly(adenosine diphosphate-ribose) polymerase by the active form of vitamin D. Int J Mol Med 19: 947-952, 2007.
APA
Mabley, J.G., Wallace, R., Pacher, P., Murphy, K., & Szabó, C. (2007). Inhibition of poly(adenosine diphosphate-ribose) polymerase by the active form of vitamin D. International Journal of Molecular Medicine, 19, 947-952. https://doi.org/10.3892/ijmm.19.6.947
MLA
Mabley, J. G., Wallace, R., Pacher, P., Murphy, K., Szabó, C."Inhibition of poly(adenosine diphosphate-ribose) polymerase by the active form of vitamin D". International Journal of Molecular Medicine 19.6 (2007): 947-952.
Chicago
Mabley, J. G., Wallace, R., Pacher, P., Murphy, K., Szabó, C."Inhibition of poly(adenosine diphosphate-ribose) polymerase by the active form of vitamin D". International Journal of Molecular Medicine 19, no. 6 (2007): 947-952. https://doi.org/10.3892/ijmm.19.6.947
Copy and paste a formatted citation
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Spandidos Publications style
Mabley JG, Wallace R, Pacher P, Murphy K and Szabó C: Inhibition of poly(adenosine diphosphate-ribose) polymerase by the active form of vitamin D. Int J Mol Med 19: 947-952, 2007.
APA
Mabley, J.G., Wallace, R., Pacher, P., Murphy, K., & Szabó, C. (2007). Inhibition of poly(adenosine diphosphate-ribose) polymerase by the active form of vitamin D. International Journal of Molecular Medicine, 19, 947-952. https://doi.org/10.3892/ijmm.19.6.947
MLA
Mabley, J. G., Wallace, R., Pacher, P., Murphy, K., Szabó, C."Inhibition of poly(adenosine diphosphate-ribose) polymerase by the active form of vitamin D". International Journal of Molecular Medicine 19.6 (2007): 947-952.
Chicago
Mabley, J. G., Wallace, R., Pacher, P., Murphy, K., Szabó, C."Inhibition of poly(adenosine diphosphate-ribose) polymerase by the active form of vitamin D". International Journal of Molecular Medicine 19, no. 6 (2007): 947-952. https://doi.org/10.3892/ijmm.19.6.947
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