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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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Aug 1998 Volume 2 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Aug 1998 Volume 2 Issue 2

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Article

Loss of heterozygosity and microsatellite instability in non-neoplastic mucosa from patients with chronic ulcerative colitis.

  • Authors:
    • WS Park
    • T Pham
    • C Wang
    • S Pack
    • E Mueller
    • J Mueller
    • A Vortmeyer
    • Z Zhuang
    • F Fogt

  • View Affiliations / Copyright

    Affiliations: Department of Pathology, National Institutes of Health, Bethesda, MD, USA.
  • Pages: 221-445
    |
    Published online on: August 1, 1998
       https://doi.org/10.3892/ijmm.2.2.221
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Abstract

Microsatellite instability and allelic deletions of tumor suppressor genes have been observed frequently in tumors. Molecular pathogenesis of the development of dysplasia and carcinoma in ulcerative colitis is still unclear. In order to detect microsatellite alterations in ulcerative colitis, we analyzed loss of heterozygosity (LOH) and microsatellite instability (MI) on chromosomes 3, 6, 7, 12, and tumor suppressor gene loci, including p53, APC, and p16, of chronically inflamed, non-dysplastic epithelium after microdissection. Twelve of 13 (92%) cases showed LOH and/or MI at one or more loci. LOH at chromosome 3 and MI at chromosome 12 were observed in 50% and 62%, respectively. However, LOH at p53 and p16 was detected in only one case each. These results suggest that chronic inflammation may initiate microsatellite alteration, which subsequently transform ulcerative colitis to dysplasia or cancer. This finding provides information for the evaluation and treatment of patients with ulcerative colitis.

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Copy and paste a formatted citation
Spandidos Publications style
Park W, Pham T, Wang C, Pack S, Mueller E, Mueller J, Vortmeyer A, Zhuang Z and Fogt F: Loss of heterozygosity and microsatellite instability in non-neoplastic mucosa from patients with chronic ulcerative colitis.. Int J Mol Med 2: 221-445, 1998.
APA
Park, W., Pham, T., Wang, C., Pack, S., Mueller, E., Mueller, J. ... Fogt, F. (1998). Loss of heterozygosity and microsatellite instability in non-neoplastic mucosa from patients with chronic ulcerative colitis.. International Journal of Molecular Medicine, 2, 221-445. https://doi.org/10.3892/ijmm.2.2.221
MLA
Park, W., Pham, T., Wang, C., Pack, S., Mueller, E., Mueller, J., Vortmeyer, A., Zhuang, Z., Fogt, F."Loss of heterozygosity and microsatellite instability in non-neoplastic mucosa from patients with chronic ulcerative colitis.". International Journal of Molecular Medicine 2.2 (1998): 221-445.
Chicago
Park, W., Pham, T., Wang, C., Pack, S., Mueller, E., Mueller, J., Vortmeyer, A., Zhuang, Z., Fogt, F."Loss of heterozygosity and microsatellite instability in non-neoplastic mucosa from patients with chronic ulcerative colitis.". International Journal of Molecular Medicine 2, no. 2 (1998): 221-445. https://doi.org/10.3892/ijmm.2.2.221
Copy and paste a formatted citation
x
Spandidos Publications style
Park W, Pham T, Wang C, Pack S, Mueller E, Mueller J, Vortmeyer A, Zhuang Z and Fogt F: Loss of heterozygosity and microsatellite instability in non-neoplastic mucosa from patients with chronic ulcerative colitis.. Int J Mol Med 2: 221-445, 1998.
APA
Park, W., Pham, T., Wang, C., Pack, S., Mueller, E., Mueller, J. ... Fogt, F. (1998). Loss of heterozygosity and microsatellite instability in non-neoplastic mucosa from patients with chronic ulcerative colitis.. International Journal of Molecular Medicine, 2, 221-445. https://doi.org/10.3892/ijmm.2.2.221
MLA
Park, W., Pham, T., Wang, C., Pack, S., Mueller, E., Mueller, J., Vortmeyer, A., Zhuang, Z., Fogt, F."Loss of heterozygosity and microsatellite instability in non-neoplastic mucosa from patients with chronic ulcerative colitis.". International Journal of Molecular Medicine 2.2 (1998): 221-445.
Chicago
Park, W., Pham, T., Wang, C., Pack, S., Mueller, E., Mueller, J., Vortmeyer, A., Zhuang, Z., Fogt, F."Loss of heterozygosity and microsatellite instability in non-neoplastic mucosa from patients with chronic ulcerative colitis.". International Journal of Molecular Medicine 2, no. 2 (1998): 221-445. https://doi.org/10.3892/ijmm.2.2.221
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