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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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Sep 1998 Volume 2 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Sep 1998 Volume 2 Issue 3

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Article

5'-flanking motifs control cell-specific expression of trefoil factor genes (TFF).

  • Authors:
    • S Beck
    • P Sommer
    • N Blin
    • P Gött

  • View Affiliations / Copyright

    Affiliations: Division of Molecular Genetics, Institute of Anthropology and Human Genetics, University of Tübingen, Germany.
  • Pages: 353-414
    |
    Published online on: September 1, 1998
       https://doi.org/10.3892/ijmm.2.3.353
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Abstract

A group of secreted peptides (trefoil factor family; TFF) is abundantly expressed at mucosal surfaces of the gastrointestinal tract and promote epithelial restitution. They are upregulated around areas of epithelial damage, ulceration and neoplasia. The transcriptional regulation of the three human TFF genes was assayed by multiplex RT-PCR and reporter gene analysis in 8 gastrointestinal carcinoma cell lines. The level of endogenous mRNA matched well the reporter gene activity of all TFFs, indicating that the cis-acting elements located less than 1,000 bp upstream of the TATAA box account for cell-specific gene expression. In HT-29, the endogenous TFF expression profile changed in relation to cell growth conditions. Deletion and mutation analysis of TFF promoter constructs revealed enhancing elements shared within the three TFF promoters that were shown to bind nuclear proteins. Thus such specific DNA-protein interaction may explain the TFF peptides' cell specific expression pattern and altered levels in pathological conditions.

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Copy and paste a formatted citation
Spandidos Publications style
Beck S, Sommer P, Blin N and Gött P: 5'-flanking motifs control cell-specific expression of trefoil factor genes (TFF).. Int J Mol Med 2: 353-414, 1998.
APA
Beck, S., Sommer, P., Blin, N., & Gött, P. (1998). 5'-flanking motifs control cell-specific expression of trefoil factor genes (TFF).. International Journal of Molecular Medicine, 2, 353-414. https://doi.org/10.3892/ijmm.2.3.353
MLA
Beck, S., Sommer, P., Blin, N., Gött, P."5'-flanking motifs control cell-specific expression of trefoil factor genes (TFF).". International Journal of Molecular Medicine 2.3 (1998): 353-414.
Chicago
Beck, S., Sommer, P., Blin, N., Gött, P."5'-flanking motifs control cell-specific expression of trefoil factor genes (TFF).". International Journal of Molecular Medicine 2, no. 3 (1998): 353-414. https://doi.org/10.3892/ijmm.2.3.353
Copy and paste a formatted citation
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Spandidos Publications style
Beck S, Sommer P, Blin N and Gött P: 5'-flanking motifs control cell-specific expression of trefoil factor genes (TFF).. Int J Mol Med 2: 353-414, 1998.
APA
Beck, S., Sommer, P., Blin, N., & Gött, P. (1998). 5'-flanking motifs control cell-specific expression of trefoil factor genes (TFF).. International Journal of Molecular Medicine, 2, 353-414. https://doi.org/10.3892/ijmm.2.3.353
MLA
Beck, S., Sommer, P., Blin, N., Gött, P."5'-flanking motifs control cell-specific expression of trefoil factor genes (TFF).". International Journal of Molecular Medicine 2.3 (1998): 353-414.
Chicago
Beck, S., Sommer, P., Blin, N., Gött, P."5'-flanking motifs control cell-specific expression of trefoil factor genes (TFF).". International Journal of Molecular Medicine 2, no. 3 (1998): 353-414. https://doi.org/10.3892/ijmm.2.3.353
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