Heat shock proteins: protective effect and potential therapeutic use (review).

  • Authors:
    • D S Latchman
  • View Affiliations

  • Published online on: October 1, 1998     https://doi.org/10.3892/ijmm.2.4.375
  • Pages: 375-456
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The heat shock proteins (hsps) are induced by a variety of stressful stimuli and their overexpression has been shown to protect cells both in vitro and in vivo against such stimuli, as well as against stimuli-inducing apoptosis. The potential therapeutic benefit of elevating hsp levels in individuals with, for example, cerebral or cardiac ischaemia or neurodegenerative diseases has led to the identification of specific methods of inducing hsp expression in a non-stressful manner. These include pharmacological procedures and cytokine treatment to elevate endogenous hsp levels and the development of viral vectors to deliver exogenous hsp genes. The advantages and disadvantages of each of these methods and their ultimate therapeutic potential are discussed.

Related Articles

Journal Cover

Oct 1998
Volume 2 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Latchman D: Heat shock proteins: protective effect and potential therapeutic use (review).. Int J Mol Med 2: 375-456, 1998
APA
Latchman, D. (1998). Heat shock proteins: protective effect and potential therapeutic use (review).. International Journal of Molecular Medicine, 2, 375-456. https://doi.org/10.3892/ijmm.2.4.375
MLA
Latchman, D."Heat shock proteins: protective effect and potential therapeutic use (review).". International Journal of Molecular Medicine 2.4 (1998): 375-456.
Chicago
Latchman, D."Heat shock proteins: protective effect and potential therapeutic use (review).". International Journal of Molecular Medicine 2, no. 4 (1998): 375-456. https://doi.org/10.3892/ijmm.2.4.375