Endopeptidase 24.11/CD10 is down-regulated in renal cell cancer.

  • Authors:
    • B Göhring
    • H J Holzhausen
    • A Meye
    • H Heynemann
    • U Rebmann
    • J Langner
    • D Riemann
  • View Affiliations

  • Published online on: October 1, 1998     https://doi.org/10.3892/ijmm.2.4.409
  • Pages: 409-423
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The regulatory mechanisms responsible for malignant transformation, tumor progression and metastasis in renal cell cancer (RCC) are still unclear, but there is some evidence that biologically active peptides might have regulatory effects on the behavior of this malignancy. Tumor cells can change local concentrations of active peptides by modulating their cell-surface enzymes. Using immunohistochemistry and enzyme-histochemistry, the expression of various membrane peptidases was examined in RCC and adjacent noninvaded renal parenchyma (n = 44). We describe the down-regulation of neutral endopeptidase 24.11 (NEP) protein expression in RCC of the clear cell/chromophilic type when compared with renal parenchyma, and show for the first time the lack of enzyme activity of NEP in RCC. The strongest expression could be found for dipeptidyl peptidase IV (DPIV) which is only decreased in RCC of the chromophobe cell type and is even present in oncocytoma. Aminopeptidase N (APN) and aminopeptidase A (APA) show attenuated expression in up to one third of clear cell/ chromophilic RCC. Chromophobe RCC and oncocytomas do not express APN, APA, NEP and gamma-glutamyltranspeptidase.

Related Articles

Journal Cover

Oct 1998
Volume 2 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Göhring B, Holzhausen H, Meye A, Heynemann H, Rebmann U, Langner J and Riemann D: Endopeptidase 24.11/CD10 is down-regulated in renal cell cancer.. Int J Mol Med 2: 409-423, 1998
APA
Göhring, B., Holzhausen, H., Meye, A., Heynemann, H., Rebmann, U., Langner, J., & Riemann, D. (1998). Endopeptidase 24.11/CD10 is down-regulated in renal cell cancer.. International Journal of Molecular Medicine, 2, 409-423. https://doi.org/10.3892/ijmm.2.4.409
MLA
Göhring, B., Holzhausen, H., Meye, A., Heynemann, H., Rebmann, U., Langner, J., Riemann, D."Endopeptidase 24.11/CD10 is down-regulated in renal cell cancer.". International Journal of Molecular Medicine 2.4 (1998): 409-423.
Chicago
Göhring, B., Holzhausen, H., Meye, A., Heynemann, H., Rebmann, U., Langner, J., Riemann, D."Endopeptidase 24.11/CD10 is down-regulated in renal cell cancer.". International Journal of Molecular Medicine 2, no. 4 (1998): 409-423. https://doi.org/10.3892/ijmm.2.4.409