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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
Oct 1998 Volume 2 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
Oct 1998 Volume 2 Issue 4

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Article

Thymidine phosphorylase activity in tumor correlates with venous invasion.

  • Authors:
    • B Nakata
    • K H Chung
    • Y Kato
    • Y Yamashita
    • N Onoda
    • K Maeda
    • M Sowa
  • View Affiliations / Copyright

    Affiliations: First Department of Surgery, Osaka City University Medical School, 1-4-3 Asahimachi, Abeno-ku, Osaka 545-8585, Japan.
  • Pages: 461-465
    |
    Published online on: October 1, 1998
       https://doi.org/10.3892/ijmm.2.4.461
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Abstract

Thymidine phosphorylase (dThdPase) is identical to platelet-derived endothelial cell growth factor (PD-ECGF), an angiogenesis factor. We investigated the correlation between dThdPase activity in gastric cancer tissue and clinicopathological factors. Thirty-three cancer tissue specimens and 23 adjacent normal gastric mucosal specimens were obtained from surgery. Measurement of dThdPase activity was based on the amount of 5-fluorouracil formed from 5'-deoxy-5-fluorouridine by dThdPase. Mean dThdPase activity in cancer tissue was approximately 3.2 times higher than that in normal tissue. Cancerous tissues with venous invasion had about twice the dThdPase activity as cancerous tissues without venous invasion. Other clinicopathological features were not related to dThdPase activity. A correlation between dThdPase activity and immunosuppressive acidic protein level was observed (r = 0.532, P = 0.005). dThdPase activity in gastric cancer cells was found to be correlated with venous invasion, supporting previous findings that it plays a role in tumor angiogenesis.

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Copy and paste a formatted citation
Spandidos Publications style
Nakata B, Chung K, Kato Y, Yamashita Y, Onoda N, Maeda K and Sowa M: Thymidine phosphorylase activity in tumor correlates with venous invasion.. Int J Mol Med 2: 461-465, 1998.
APA
Nakata, B., Chung, K., Kato, Y., Yamashita, Y., Onoda, N., Maeda, K., & Sowa, M. (1998). Thymidine phosphorylase activity in tumor correlates with venous invasion.. International Journal of Molecular Medicine, 2, 461-465. https://doi.org/10.3892/ijmm.2.4.461
MLA
Nakata, B., Chung, K., Kato, Y., Yamashita, Y., Onoda, N., Maeda, K., Sowa, M."Thymidine phosphorylase activity in tumor correlates with venous invasion.". International Journal of Molecular Medicine 2.4 (1998): 461-465.
Chicago
Nakata, B., Chung, K., Kato, Y., Yamashita, Y., Onoda, N., Maeda, K., Sowa, M."Thymidine phosphorylase activity in tumor correlates with venous invasion.". International Journal of Molecular Medicine 2, no. 4 (1998): 461-465. https://doi.org/10.3892/ijmm.2.4.461
Copy and paste a formatted citation
x
Spandidos Publications style
Nakata B, Chung K, Kato Y, Yamashita Y, Onoda N, Maeda K and Sowa M: Thymidine phosphorylase activity in tumor correlates with venous invasion.. Int J Mol Med 2: 461-465, 1998.
APA
Nakata, B., Chung, K., Kato, Y., Yamashita, Y., Onoda, N., Maeda, K., & Sowa, M. (1998). Thymidine phosphorylase activity in tumor correlates with venous invasion.. International Journal of Molecular Medicine, 2, 461-465. https://doi.org/10.3892/ijmm.2.4.461
MLA
Nakata, B., Chung, K., Kato, Y., Yamashita, Y., Onoda, N., Maeda, K., Sowa, M."Thymidine phosphorylase activity in tumor correlates with venous invasion.". International Journal of Molecular Medicine 2.4 (1998): 461-465.
Chicago
Nakata, B., Chung, K., Kato, Y., Yamashita, Y., Onoda, N., Maeda, K., Sowa, M."Thymidine phosphorylase activity in tumor correlates with venous invasion.". International Journal of Molecular Medicine 2, no. 4 (1998): 461-465. https://doi.org/10.3892/ijmm.2.4.461
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