The non-env tropism of HIV/SIV (Review).

  • Authors:
    • R Shimano
    • R Inubushi
    • M Tamaki
    • H Akari
    • A H Koyama
    • A Adachi
  • View Affiliations

  • Published online on: November 1, 1998     https://doi.org/10.3892/ijmm.2.5.541
  • Pages: 541-545
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The tropism of human and simian immunodeficiency viruses (HIV and SIV) determined by sequences other than env has been studied. The restriction of HIV-1 replication in monkey cells was demonstrated to be regulated by viral non-env sequence. Likewise, the gag-pol region of SIVagm (virus of the African green monkey) genome was found to be responsible for growth restriction in human cells of the virus. No viral DNA synthesis was detected in cells nonpermissive for the viruses. In addition, a number of HIV-1 gag gene mutants, which have an early defect in viral replication cycle and direct no viral DNA synthesis in some cells, exhibited a phenotype of host range mutant. Taken together, it can be concluded that the viral tropism associated with the uncoating/ reverse transcription process does exist in HIV/SIV replication. Furthermore, many of the accessory gene mutants of HIV/SIV exhibit host cell-dependent replication property. In this review, we summarize these examples of non-env tropism of HIV/SIV.

Related Articles

Journal Cover

Nov 1998
Volume 2 Issue 5

Print ISSN: 1107-3756
Online ISSN:1791-244X

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Shimano R, Inubushi R, Tamaki M, Akari H, Koyama A and Adachi A: The non-env tropism of HIV/SIV (Review).. Int J Mol Med 2: 541-545, 1998.
APA
Shimano, R., Inubushi, R., Tamaki, M., Akari, H., Koyama, A., & Adachi, A. (1998). The non-env tropism of HIV/SIV (Review).. International Journal of Molecular Medicine, 2, 541-545. https://doi.org/10.3892/ijmm.2.5.541
MLA
Shimano, R., Inubushi, R., Tamaki, M., Akari, H., Koyama, A., Adachi, A."The non-env tropism of HIV/SIV (Review).". International Journal of Molecular Medicine 2.5 (1998): 541-545.
Chicago
Shimano, R., Inubushi, R., Tamaki, M., Akari, H., Koyama, A., Adachi, A."The non-env tropism of HIV/SIV (Review).". International Journal of Molecular Medicine 2, no. 5 (1998): 541-545. https://doi.org/10.3892/ijmm.2.5.541