Abnormal stress response and increased fighting behavior in mice lacking the bcr gene product.

  • Authors:
    • J W Voncken
    • T Z Baram
    • I Gonzales-Gomez
    • H Van Schaick
    • J C Shih
    • K Chen
    • J Groffen
    • N Heisterkamp
  • View Affiliations

  • Published online on: November 1, 1998     https://doi.org/10.3892/ijmm.2.5.577
  • Pages: 577-660
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The in vivo function of proteins which regulate activity of the GTPase Rac is largely unknown. Here we establish that mice lacking bcr, a known GTPase activating protein for Rac, exhibit a defect in the regulation of both hormonal and behavioral stress responses. Bcr null mutants demonstrate prolonged elevation of plasma glucocorticoids and increased fighting in males in response to physiological and social stress, respectively. Combined biochemical and behavioral data indicate that bcr is involved in mediating the cellular effects of glucocorticoids, specifically down-regulation of the stress-activated hippocampal hypothalamic-pituitary-adrenal axis.

Related Articles

Journal Cover

Nov 1998
Volume 2 Issue 5

Print ISSN: 1107-3756
Online ISSN:1791-244X

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Voncken J, Baram T, Gonzales-Gomez I, Van Schaick H, Shih J, Chen K, Groffen J and Heisterkamp N: Abnormal stress response and increased fighting behavior in mice lacking the bcr gene product.. Int J Mol Med 2: 577-660, 1998
APA
Voncken, J., Baram, T., Gonzales-Gomez, I., Van Schaick, H., Shih, J., Chen, K. ... Heisterkamp, N. (1998). Abnormal stress response and increased fighting behavior in mice lacking the bcr gene product.. International Journal of Molecular Medicine, 2, 577-660. https://doi.org/10.3892/ijmm.2.5.577
MLA
Voncken, J., Baram, T., Gonzales-Gomez, I., Van Schaick, H., Shih, J., Chen, K., Groffen, J., Heisterkamp, N."Abnormal stress response and increased fighting behavior in mice lacking the bcr gene product.". International Journal of Molecular Medicine 2.5 (1998): 577-660.
Chicago
Voncken, J., Baram, T., Gonzales-Gomez, I., Van Schaick, H., Shih, J., Chen, K., Groffen, J., Heisterkamp, N."Abnormal stress response and increased fighting behavior in mice lacking the bcr gene product.". International Journal of Molecular Medicine 2, no. 5 (1998): 577-660. https://doi.org/10.3892/ijmm.2.5.577