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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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July 2007 Volume 20 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July 2007 Volume 20 Issue 1

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Article

Heat shock proteins play a crucial role in tumor-specific apoptosis by REIC/Dkk-3

  • Authors:
    • Fernando Abarzua
    • Masakiyo Sakaguchi
    • Ryuta Tanimoto
    • Hiroyuki Sonegawa
    • Dai-Wei Li
    • Kohei Edamura
    • Tomoko Kobayashi
    • Masami Watanabe
    • Yuji Kashiwakura
    • Haruki Kaku
    • Takashi Saika
    • Keiichiro Nakamura
    • Yasutomo Nasu
    • Hiromi Kumon
    • Nam-Ho Huh

  • View Affiliations / Copyright

    Affiliations: Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan
  • Pages: 37-43
    |
    Published online on: July 1, 2007
       https://doi.org/10.3892/ijmm.20.1.37
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Abstract

We recently showed that overexpression of REIC/Dickkopf-3 (Dkk-3), a tumor suppressor gene, induced apoptosis in a tumor cell-specific manner. The aim of the present study was to determine the mechanisms underlying the selective induction of apoptosis. At first, we found a mouse renal carcinoma cell line, RENCA, to be extremely sensitive to an adenovirus carrying REIC/Dkk-3 (Ad-REIC), and we showed that activation of c-Jun N-terminal kinase (JNK) was a critical step in cell death, i.e. a process similar to that in human prostate and testicular cancer observed in our previous studies. Among the proteins interfering with the activation of JNK, heat shock protein (Hsp)70/72 was reduced in expression in RENCA cells compared with that in NIH3T3 cells. An Hsp70/72 inducer protected RENCA cells from Ad-REIC-induced apoptosis, while an Hsp70/72 inhibitor sensitized NIH3T3 cells for apoptosis induction. These results indicate that functionally active Hsp70/72 is a key factor in tumor cell-specific induction of apoptotic cell death and that analyses of the expression levels of Hsp70/72 may be essential in determining the significance of Ad-REIC-based gene therapy against human cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Abarzua F, Sakaguchi M, Tanimoto R, Sonegawa H, Li D, Edamura K, Kobayashi T, Watanabe M, Kashiwakura Y, Kaku H, Kaku H, et al: Heat shock proteins play a crucial role in tumor-specific apoptosis by REIC/Dkk-3. Int J Mol Med 20: 37-43, 2007.
APA
Abarzua, F., Sakaguchi, M., Tanimoto, R., Sonegawa, H., Li, D., Edamura, K. ... Huh, N. (2007). Heat shock proteins play a crucial role in tumor-specific apoptosis by REIC/Dkk-3. International Journal of Molecular Medicine, 20, 37-43. https://doi.org/10.3892/ijmm.20.1.37
MLA
Abarzua, F., Sakaguchi, M., Tanimoto, R., Sonegawa, H., Li, D., Edamura, K., Kobayashi, T., Watanabe, M., Kashiwakura, Y., Kaku, H., Saika, T., Nakamura, K., Nasu, Y., Kumon, H., Huh, N."Heat shock proteins play a crucial role in tumor-specific apoptosis by REIC/Dkk-3". International Journal of Molecular Medicine 20.1 (2007): 37-43.
Chicago
Abarzua, F., Sakaguchi, M., Tanimoto, R., Sonegawa, H., Li, D., Edamura, K., Kobayashi, T., Watanabe, M., Kashiwakura, Y., Kaku, H., Saika, T., Nakamura, K., Nasu, Y., Kumon, H., Huh, N."Heat shock proteins play a crucial role in tumor-specific apoptosis by REIC/Dkk-3". International Journal of Molecular Medicine 20, no. 1 (2007): 37-43. https://doi.org/10.3892/ijmm.20.1.37
Copy and paste a formatted citation
x
Spandidos Publications style
Abarzua F, Sakaguchi M, Tanimoto R, Sonegawa H, Li D, Edamura K, Kobayashi T, Watanabe M, Kashiwakura Y, Kaku H, Kaku H, et al: Heat shock proteins play a crucial role in tumor-specific apoptosis by REIC/Dkk-3. Int J Mol Med 20: 37-43, 2007.
APA
Abarzua, F., Sakaguchi, M., Tanimoto, R., Sonegawa, H., Li, D., Edamura, K. ... Huh, N. (2007). Heat shock proteins play a crucial role in tumor-specific apoptosis by REIC/Dkk-3. International Journal of Molecular Medicine, 20, 37-43. https://doi.org/10.3892/ijmm.20.1.37
MLA
Abarzua, F., Sakaguchi, M., Tanimoto, R., Sonegawa, H., Li, D., Edamura, K., Kobayashi, T., Watanabe, M., Kashiwakura, Y., Kaku, H., Saika, T., Nakamura, K., Nasu, Y., Kumon, H., Huh, N."Heat shock proteins play a crucial role in tumor-specific apoptosis by REIC/Dkk-3". International Journal of Molecular Medicine 20.1 (2007): 37-43.
Chicago
Abarzua, F., Sakaguchi, M., Tanimoto, R., Sonegawa, H., Li, D., Edamura, K., Kobayashi, T., Watanabe, M., Kashiwakura, Y., Kaku, H., Saika, T., Nakamura, K., Nasu, Y., Kumon, H., Huh, N."Heat shock proteins play a crucial role in tumor-specific apoptosis by REIC/Dkk-3". International Journal of Molecular Medicine 20, no. 1 (2007): 37-43. https://doi.org/10.3892/ijmm.20.1.37
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