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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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August 2007 Volume 20 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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August 2007 Volume 20 Issue 2

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Article

Decreased expression of claudin-1 correlates with recurrence status in breast cancer

  • Authors:
    • Satoko Morohashi
    • Tomomi Kusumi
    • Fuyuki Sato
    • Hiroki Odagiri
    • Hiroki Chiba
    • Shuichi Yoshihara
    • Kenichi Hakamada
    • Mutsuo Sasaki
    • Hiroshi Kijima

  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Hirosaki University School of Medicine, Aomori 036-8562, Japan
  • Pages: 139-143
    |
    Published online on: August 1, 2007
       https://doi.org/10.3892/ijmm.20.2.139
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Abstract

Claudins (CLDNs) constitute the major transmembrane proteins of tight junctions. It may be hypothesized that changes in or loss of expression of tight junctional proteins such as CLDNs can lead to cellular disorientation and detachment, which is commonly seen in neoplasia. Recent studies have suggested that claudin-1 (CLDN1) plays an important role in invasion and metastasis and claudin-4 (CLDN4) has a particular role in mammary glandular cell differentiation and carcinogenesis. In this study, we examined 83 breast cancer cases and demonstrated immunohistochemical expression patterns of CLDN1/CLDN4 in recurrent and non-recurrent groups. We found significant results between the recurrent and non-recurrent group for expression of CLDN1/CLDN4. The recurrent group (26 cases) showed decreased expression patterns of CLDN1 (p<0.001), compared to the non-recurrent group (57 cases). Decreased expression of CLDN1 (p<0.0001) correlated with short disease-free interval. The lymph node metastasis-positive group showed decreased expression patterns of CLDN1 (p=0.001). However, there was no significance between the recurrent group and non-recurrent group in CLDN4 expression. There was no significance between histological factors and CLDN4 expression. The results indicated that CLDN1 expression correlated with the recurrence status and malignant potential of breast cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Morohashi S, Kusumi T, Sato F, Odagiri H, Chiba H, Yoshihara S, Hakamada K, Sasaki M and Kijima H: Decreased expression of claudin-1 correlates with recurrence status in breast cancer. Int J Mol Med 20: 139-143, 2007.
APA
Morohashi, S., Kusumi, T., Sato, F., Odagiri, H., Chiba, H., Yoshihara, S. ... Kijima, H. (2007). Decreased expression of claudin-1 correlates with recurrence status in breast cancer. International Journal of Molecular Medicine, 20, 139-143. https://doi.org/10.3892/ijmm.20.2.139
MLA
Morohashi, S., Kusumi, T., Sato, F., Odagiri, H., Chiba, H., Yoshihara, S., Hakamada, K., Sasaki, M., Kijima, H."Decreased expression of claudin-1 correlates with recurrence status in breast cancer". International Journal of Molecular Medicine 20.2 (2007): 139-143.
Chicago
Morohashi, S., Kusumi, T., Sato, F., Odagiri, H., Chiba, H., Yoshihara, S., Hakamada, K., Sasaki, M., Kijima, H."Decreased expression of claudin-1 correlates with recurrence status in breast cancer". International Journal of Molecular Medicine 20, no. 2 (2007): 139-143. https://doi.org/10.3892/ijmm.20.2.139
Copy and paste a formatted citation
x
Spandidos Publications style
Morohashi S, Kusumi T, Sato F, Odagiri H, Chiba H, Yoshihara S, Hakamada K, Sasaki M and Kijima H: Decreased expression of claudin-1 correlates with recurrence status in breast cancer. Int J Mol Med 20: 139-143, 2007.
APA
Morohashi, S., Kusumi, T., Sato, F., Odagiri, H., Chiba, H., Yoshihara, S. ... Kijima, H. (2007). Decreased expression of claudin-1 correlates with recurrence status in breast cancer. International Journal of Molecular Medicine, 20, 139-143. https://doi.org/10.3892/ijmm.20.2.139
MLA
Morohashi, S., Kusumi, T., Sato, F., Odagiri, H., Chiba, H., Yoshihara, S., Hakamada, K., Sasaki, M., Kijima, H."Decreased expression of claudin-1 correlates with recurrence status in breast cancer". International Journal of Molecular Medicine 20.2 (2007): 139-143.
Chicago
Morohashi, S., Kusumi, T., Sato, F., Odagiri, H., Chiba, H., Yoshihara, S., Hakamada, K., Sasaki, M., Kijima, H."Decreased expression of claudin-1 correlates with recurrence status in breast cancer". International Journal of Molecular Medicine 20, no. 2 (2007): 139-143. https://doi.org/10.3892/ijmm.20.2.139
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