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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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August 2007 Volume 20 Issue 2

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Late-onset olfactory deficits and mitral cell loss in mice lacking prion protein with ectopic expression of Doppel

  • Authors:
    • Chi-Kyeong Kim
    • Akikazu Sakudo
    • Yojiro Taniuchi
    • Kazuto Shigematsu
    • Chung-Boo Kang
    • Keiichi Saeki
    • Yoshitsugu Matsumoto
    • Suehiro Sakaguchi
    • Shigeyoshi Itohara
    • Takashi Onodera

  • View Affiliations / Copyright

    Affiliations: Department of Molecular Immunology, School of Agricultural and Life Sciences, University of Tokyo, Tokyo 113-8657, Japan
  • Pages: 169-176
    |
    Published online on: August 1, 2007
       https://doi.org/10.3892/ijmm.20.2.169
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Abstract

Several lines of prion protein gene (Prnp)-knockout mice such as ZrchI, ZrchII, Npu, Ngsk and Rcm0 have been generated. Of these, ZrchII, Ngsk and Rcm0 exhibit late-onset ataxia due to ectopic expression of Doppel (Dpl); a result of damage to the splicing acceptor of Prnp exon 3. Recently, we developed another line of Prnp−/− mice (Rikn), which was generated by gene targeting with more nucleotides by replacing intron 2 with the pgk-neo gene (cf. Ngsk Prnp−/− mice) and showed not only ataxia but also a lower olfactory sensitivity than the other Prnp−/− mouse line ZrchI at over 60 weeks of age. The histopathology of the elderly Rikn Prnp−/− mice showed mitral cell loss concomitantly observed with gliosis of astrocytes. Western blot analysis showed that Dpl was detected in the cerebrum, cerebellum and olfactory bulb of Rikn Prnp−/− mice, where aberrant histopathology was observed. Thus, mitral cell loss and gliosis induced by ectopic Dpl expression were probably associated with the late-onset olfactory deficits in Rikn Prnp−/− mice.

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Copy and paste a formatted citation
Spandidos Publications style
Kim C, Sakudo A, Taniuchi Y, Shigematsu K, Kang C, Saeki K, Matsumoto Y, Sakaguchi S, Itohara S, Onodera T, Onodera T, et al: Late-onset olfactory deficits and mitral cell loss in mice lacking prion protein with ectopic expression of Doppel. Int J Mol Med 20: 169-176, 2007.
APA
Kim, C., Sakudo, A., Taniuchi, Y., Shigematsu, K., Kang, C., Saeki, K. ... Onodera, T. (2007). Late-onset olfactory deficits and mitral cell loss in mice lacking prion protein with ectopic expression of Doppel. International Journal of Molecular Medicine, 20, 169-176. https://doi.org/10.3892/ijmm.20.2.169
MLA
Kim, C., Sakudo, A., Taniuchi, Y., Shigematsu, K., Kang, C., Saeki, K., Matsumoto, Y., Sakaguchi, S., Itohara, S., Onodera, T."Late-onset olfactory deficits and mitral cell loss in mice lacking prion protein with ectopic expression of Doppel". International Journal of Molecular Medicine 20.2 (2007): 169-176.
Chicago
Kim, C., Sakudo, A., Taniuchi, Y., Shigematsu, K., Kang, C., Saeki, K., Matsumoto, Y., Sakaguchi, S., Itohara, S., Onodera, T."Late-onset olfactory deficits and mitral cell loss in mice lacking prion protein with ectopic expression of Doppel". International Journal of Molecular Medicine 20, no. 2 (2007): 169-176. https://doi.org/10.3892/ijmm.20.2.169
Copy and paste a formatted citation
x
Spandidos Publications style
Kim C, Sakudo A, Taniuchi Y, Shigematsu K, Kang C, Saeki K, Matsumoto Y, Sakaguchi S, Itohara S, Onodera T, Onodera T, et al: Late-onset olfactory deficits and mitral cell loss in mice lacking prion protein with ectopic expression of Doppel. Int J Mol Med 20: 169-176, 2007.
APA
Kim, C., Sakudo, A., Taniuchi, Y., Shigematsu, K., Kang, C., Saeki, K. ... Onodera, T. (2007). Late-onset olfactory deficits and mitral cell loss in mice lacking prion protein with ectopic expression of Doppel. International Journal of Molecular Medicine, 20, 169-176. https://doi.org/10.3892/ijmm.20.2.169
MLA
Kim, C., Sakudo, A., Taniuchi, Y., Shigematsu, K., Kang, C., Saeki, K., Matsumoto, Y., Sakaguchi, S., Itohara, S., Onodera, T."Late-onset olfactory deficits and mitral cell loss in mice lacking prion protein with ectopic expression of Doppel". International Journal of Molecular Medicine 20.2 (2007): 169-176.
Chicago
Kim, C., Sakudo, A., Taniuchi, Y., Shigematsu, K., Kang, C., Saeki, K., Matsumoto, Y., Sakaguchi, S., Itohara, S., Onodera, T."Late-onset olfactory deficits and mitral cell loss in mice lacking prion protein with ectopic expression of Doppel". International Journal of Molecular Medicine 20, no. 2 (2007): 169-176. https://doi.org/10.3892/ijmm.20.2.169
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