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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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August 2007 Volume 20 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

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August 2007 Volume 20 Issue 2

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Article

Ethyl pyruvate induces necrosis-to-apoptosis switch and inhibits high mobility group box protein 1 release in A549 lung adenocarcinoma cells

  • Authors:
    • Sung-Chul Lim
    • Jeong Eun Choi
    • Cho Hee Kim
    • Hong-Quan Duong
    • Gui-Ae Jeong
    • Ho Sung Kang
    • Song Iy Han

  • View Affiliations / Copyright

    Affiliations: Research Center for Resistant Cells, College of Medicine, Chosun University, Gwangju 501-759, Korea
  • Pages: 187-192
    |
    Published online on: August 1, 2007
       https://doi.org/10.3892/ijmm.20.2.187
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Abstract

Ethyl pyruvate (EP), a stable lipophilic pyruvate derivative, has been shown to exert anti-inflammatory activities through inhibiting the expression of various pro-inflammatory mediators as well as circulating levels of high mobility group box protein 1 (HMGB1) in a variety of in vitro and in vivo model systems. Necrotic cell death triggers an inflammatory response through release of HMGB1 in the extracellular space due to the membrane rupture. In an effort to better understand the pharmacological action mechanism that could explain the anti-inflammatory properties of EP, we examined the effects of EP on necrotic cell death in A549 lung adenocarcinoma cells in response to glucose deprivation (GD), a common characteristic of the tumor microenvironment. Here we show that EP prevented GD-induced necrosis and HMGB1 release and switched the cell death mode to apoptosis through inhibiting GD-induced CuZn superoxide dismutase release and ROS production. These results suggest that the necrosis-to-apoptosis switch activity of EP may contribute to its anti-inflammatory action and that EP may suppress tumor development possibly through its activity to induce the cell death mode switch from tumor promoting necrotic cell death to tumor suppressive apoptotic cell death.

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Copy and paste a formatted citation
Spandidos Publications style
Lim S, Choi JE, Kim CH, Duong H, Jeong G, Kang HS and Han SI: Ethyl pyruvate induces necrosis-to-apoptosis switch and inhibits high mobility group box protein 1 release in A549 lung adenocarcinoma cells. Int J Mol Med 20: 187-192, 2007.
APA
Lim, S., Choi, J.E., Kim, C.H., Duong, H., Jeong, G., Kang, H.S., & Han, S.I. (2007). Ethyl pyruvate induces necrosis-to-apoptosis switch and inhibits high mobility group box protein 1 release in A549 lung adenocarcinoma cells. International Journal of Molecular Medicine, 20, 187-192. https://doi.org/10.3892/ijmm.20.2.187
MLA
Lim, S., Choi, J. E., Kim, C. H., Duong, H., Jeong, G., Kang, H. S., Han, S. I."Ethyl pyruvate induces necrosis-to-apoptosis switch and inhibits high mobility group box protein 1 release in A549 lung adenocarcinoma cells". International Journal of Molecular Medicine 20.2 (2007): 187-192.
Chicago
Lim, S., Choi, J. E., Kim, C. H., Duong, H., Jeong, G., Kang, H. S., Han, S. I."Ethyl pyruvate induces necrosis-to-apoptosis switch and inhibits high mobility group box protein 1 release in A549 lung adenocarcinoma cells". International Journal of Molecular Medicine 20, no. 2 (2007): 187-192. https://doi.org/10.3892/ijmm.20.2.187
Copy and paste a formatted citation
x
Spandidos Publications style
Lim S, Choi JE, Kim CH, Duong H, Jeong G, Kang HS and Han SI: Ethyl pyruvate induces necrosis-to-apoptosis switch and inhibits high mobility group box protein 1 release in A549 lung adenocarcinoma cells. Int J Mol Med 20: 187-192, 2007.
APA
Lim, S., Choi, J.E., Kim, C.H., Duong, H., Jeong, G., Kang, H.S., & Han, S.I. (2007). Ethyl pyruvate induces necrosis-to-apoptosis switch and inhibits high mobility group box protein 1 release in A549 lung adenocarcinoma cells. International Journal of Molecular Medicine, 20, 187-192. https://doi.org/10.3892/ijmm.20.2.187
MLA
Lim, S., Choi, J. E., Kim, C. H., Duong, H., Jeong, G., Kang, H. S., Han, S. I."Ethyl pyruvate induces necrosis-to-apoptosis switch and inhibits high mobility group box protein 1 release in A549 lung adenocarcinoma cells". International Journal of Molecular Medicine 20.2 (2007): 187-192.
Chicago
Lim, S., Choi, J. E., Kim, C. H., Duong, H., Jeong, G., Kang, H. S., Han, S. I."Ethyl pyruvate induces necrosis-to-apoptosis switch and inhibits high mobility group box protein 1 release in A549 lung adenocarcinoma cells". International Journal of Molecular Medicine 20, no. 2 (2007): 187-192. https://doi.org/10.3892/ijmm.20.2.187
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