Systemic and local levels of fetuin-A in calcific aortic valve stenosis

  • Authors:
    • Jens J. Kaden
    • Jochen O. Reinöhl
    • Birgit Blesch
    • Martina Brueckmann
    • Dariusch Haghi
    • Martin Borggrefe
    • Fabian Schmitz
    • Sebastian Klomfass
    • Manuela Pillich
    • Jan R. Ortlepp
  • View Affiliations

  • Published online on: August 1, 2007     https://doi.org/10.3892/ijmm.20.2.193
  • Pages: 193-197
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Abstract

Calcific aortic valve stenosis, the most frequent heart valve disorder in developed countries, is an actively regulated process with similarities to bone formation. Fetuin-A has recently been identified as a potent circulating inhibitor of calcification. While several studies involving patients with end-stage renal disease have shown an association between low serum fetuin-A and cardiovascular calcification, nothing is known about fetuin-A serum levels in non-renal patients with calcific aortic valve stenosis. Furthermore, while fetuin-A has been localized in calcified areas of atherosclerotic arteries, data about fetuin-A deposition in stenotic aortic valves are unavailable at present. Serum fetuin-A levels were determined in patients with (n=31) and without (n=28) calcified aortic valve stenosis by ELISA. Creatinine and CRP levels were determined and glomerular filtration rate (GFR) was calculated by the MDRD formula. Immunohistochemistry for fetuin-A was performed on human calcified stenotic (n=14) and control (n=8) aortic valves using a monoclonal antibody. Serum fetuin-A levels were lower in patients with calcific aortic stenosis as compared to the control group (1.41±0.33 versus 1.57±0,27 mg/dl; p=0.046). This difference was particularly evident in individuals with a normal GFR ≥60 ml/min (1.36±0.24 versus 1.63±0.27 mg/dl; p=0.007). Furthermore, specific staining of fetuin-A was found in stenotic valves but not in healthy control valves. The data suggest a role of fetuin-A in the pathogenesis calcific aortic valve stenosis independently of the renal function and support the concept that mechanisms of calcium homeostasis are involved in the development of calcific aortic stenosis.

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August 2007
Volume 20 Issue 2

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Kaden JJ, Reinöhl JO, Blesch B, Brueckmann M, Haghi D, Borggrefe M, Schmitz F, Klomfass S, Pillich M, Ortlepp JR, Ortlepp JR, et al: Systemic and local levels of fetuin-A in calcific aortic valve stenosis. Int J Mol Med 20: 193-197, 2007
APA
Kaden, J.J., Reinöhl, J.O., Blesch, B., Brueckmann, M., Haghi, D., Borggrefe, M. ... Ortlepp, J.R. (2007). Systemic and local levels of fetuin-A in calcific aortic valve stenosis. International Journal of Molecular Medicine, 20, 193-197. https://doi.org/10.3892/ijmm.20.2.193
MLA
Kaden, J. J., Reinöhl, J. O., Blesch, B., Brueckmann, M., Haghi, D., Borggrefe, M., Schmitz, F., Klomfass, S., Pillich, M., Ortlepp, J. R."Systemic and local levels of fetuin-A in calcific aortic valve stenosis". International Journal of Molecular Medicine 20.2 (2007): 193-197.
Chicago
Kaden, J. J., Reinöhl, J. O., Blesch, B., Brueckmann, M., Haghi, D., Borggrefe, M., Schmitz, F., Klomfass, S., Pillich, M., Ortlepp, J. R."Systemic and local levels of fetuin-A in calcific aortic valve stenosis". International Journal of Molecular Medicine 20, no. 2 (2007): 193-197. https://doi.org/10.3892/ijmm.20.2.193