Kinesin gene variability may affect tau phosphorylation in early Alzheimer's disease

  • Authors:
    • Malin E. Andersson
    • Annica Sjölander
    • Niels Andreasen
    • Lennart Minthon
    • Oskar Hansson
    • Nenad Bogdanovic
    • Christina Jern
    • Katarina Jood
    • Anders Wallin
    • Kaj Blennow
    • Henrik Zetterberg
  • View Affiliations

  • Published online on: August 1, 2007     https://doi.org/10.3892/ijmm.20.2.233
  • Pages: 233-239
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Abstract

Kinesin is a microtubule-associated motor protein that transports Alzheimer-associated amyloid precursor protein (APP) in neurons. In animal models, impaired kinesin-mediated APP transport seems to enhance formation of the neurotoxic 42 amino acid fragment of β-amyloid (Aβ42). In man, one study suggests that a polymorphism (rs8702, 56,836G>C) in the kinesin light chain 1 gene (KNS2) may affect the risk of Alzheimer's disease (AD). To further assess KNS2 as a susceptibility gene for AD we analyzed 802 patients with sporadic AD and 286 controls, 134 longitudinally followed patients with mild cognitive impairment (MCI) and 39 cognitively stable controls for the rs8702 polymorphism. The rs8702 polymorphism did not influence risk of AD (p=0.46). However, rs8702 interacted with APOE ε4 carrier status in AD (p=0.006) and influenced cerebrospinal fluid levels of hyperphosphorylated tau in MCI patients who converted to AD during follow-up (p=0.018). These findings support earlier indications that genetic variability in the KNS2 gene may play a role during early stages of AD pathogenesis.

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August 2007
Volume 20 Issue 2

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Andersson ME, Sjölander A, Andreasen N, Minthon L, Hansson O, Bogdanovic N, Jern C, Jood K, Wallin A, Blennow K, Blennow K, et al: Kinesin gene variability may affect tau phosphorylation in early Alzheimer's disease. Int J Mol Med 20: 233-239, 2007
APA
Andersson, M.E., Sjölander, A., Andreasen, N., Minthon, L., Hansson, O., Bogdanovic, N. ... Zetterberg, H. (2007). Kinesin gene variability may affect tau phosphorylation in early Alzheimer's disease. International Journal of Molecular Medicine, 20, 233-239. https://doi.org/10.3892/ijmm.20.2.233
MLA
Andersson, M. E., Sjölander, A., Andreasen, N., Minthon, L., Hansson, O., Bogdanovic, N., Jern, C., Jood, K., Wallin, A., Blennow, K., Zetterberg, H."Kinesin gene variability may affect tau phosphorylation in early Alzheimer's disease". International Journal of Molecular Medicine 20.2 (2007): 233-239.
Chicago
Andersson, M. E., Sjölander, A., Andreasen, N., Minthon, L., Hansson, O., Bogdanovic, N., Jern, C., Jood, K., Wallin, A., Blennow, K., Zetterberg, H."Kinesin gene variability may affect tau phosphorylation in early Alzheimer's disease". International Journal of Molecular Medicine 20, no. 2 (2007): 233-239. https://doi.org/10.3892/ijmm.20.2.233