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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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September 2007 Volume 20 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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September 2007 Volume 20 Issue 3

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Article

Polymorphisms in genes coding for mediators in the interleukin cascade and their effect on susceptibility to sarcoidosis in the Slovenian population

  • Authors:
    • Ales Maver
    • Igor Medica
    • Barbara Salobir
    • Miso Sabovic
    • Marjeta Tercelj
    • Borut Peterlin

  • View Affiliations / Copyright

    Affiliations: Division of Medical Genetics, Department of Gynecology and Obstetrics, University Clinical Centre, Ljubljana 1000, Slovenia
  • Pages: 385-390
    |
    Published online on: September 1, 2007
       https://doi.org/10.3892/ijmm.20.3.385
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Abstract

Sarcoidosis is a chronic inflammatory disease characterised by granulomatous inflammation in various organs. As genetic factors have been implicated in its aetiology, in our study we investigated whether the promotor polymorphisms in three genes coding for inflammatory mediators interleukin-6 (IL-6), interleukin-12 (IL-12), and interleukin-18 (IL-18) could be associated with susceptibility to sarcoidosis. The study sample consisted of 104 patients with sarcoidosis and 100 healthy control subjects. Following DNA isolation from peripheral blood the IL-6/-174G>C single nucleotide polymorphism (SNP), the IL-12B/4 bp insertion polymorphism, and the IL-18/-137G>C SNP were characterised by polymerase chain reaction. Our results showed an increased frequency of IL-6/-174C allele (p<0.01, OR=2.05, 95% CI=1.32-3.16), and also an increased genotype frequency of IL-6/-174 CC and CG carriers (p<0.01, OR=2.78, 95% CI=1.49-5.19) among sarcoidosis patients in comparison with healthy controls. Allele and genotype frequencies did not differ significantly between cases and controls for either the IL-12B/4 bp insertion polymorphism or for the IL-18/-137G>C polymorphism. In conclusion, we demonstrated that the -174G>C promotor polymorphism in the IL-6 gene may be a risk factor for sarcoidosis.

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Copy and paste a formatted citation
Spandidos Publications style
Maver A, Medica I, Salobir B, Sabovic M, Tercelj M and Peterlin B: Polymorphisms in genes coding for mediators in the interleukin cascade and their effect on susceptibility to sarcoidosis in the Slovenian population. Int J Mol Med 20: 385-390, 2007.
APA
Maver, A., Medica, I., Salobir, B., Sabovic, M., Tercelj, M., & Peterlin, B. (2007). Polymorphisms in genes coding for mediators in the interleukin cascade and their effect on susceptibility to sarcoidosis in the Slovenian population. International Journal of Molecular Medicine, 20, 385-390. https://doi.org/10.3892/ijmm.20.3.385
MLA
Maver, A., Medica, I., Salobir, B., Sabovic, M., Tercelj, M., Peterlin, B."Polymorphisms in genes coding for mediators in the interleukin cascade and their effect on susceptibility to sarcoidosis in the Slovenian population". International Journal of Molecular Medicine 20.3 (2007): 385-390.
Chicago
Maver, A., Medica, I., Salobir, B., Sabovic, M., Tercelj, M., Peterlin, B."Polymorphisms in genes coding for mediators in the interleukin cascade and their effect on susceptibility to sarcoidosis in the Slovenian population". International Journal of Molecular Medicine 20, no. 3 (2007): 385-390. https://doi.org/10.3892/ijmm.20.3.385
Copy and paste a formatted citation
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Spandidos Publications style
Maver A, Medica I, Salobir B, Sabovic M, Tercelj M and Peterlin B: Polymorphisms in genes coding for mediators in the interleukin cascade and their effect on susceptibility to sarcoidosis in the Slovenian population. Int J Mol Med 20: 385-390, 2007.
APA
Maver, A., Medica, I., Salobir, B., Sabovic, M., Tercelj, M., & Peterlin, B. (2007). Polymorphisms in genes coding for mediators in the interleukin cascade and their effect on susceptibility to sarcoidosis in the Slovenian population. International Journal of Molecular Medicine, 20, 385-390. https://doi.org/10.3892/ijmm.20.3.385
MLA
Maver, A., Medica, I., Salobir, B., Sabovic, M., Tercelj, M., Peterlin, B."Polymorphisms in genes coding for mediators in the interleukin cascade and their effect on susceptibility to sarcoidosis in the Slovenian population". International Journal of Molecular Medicine 20.3 (2007): 385-390.
Chicago
Maver, A., Medica, I., Salobir, B., Sabovic, M., Tercelj, M., Peterlin, B."Polymorphisms in genes coding for mediators in the interleukin cascade and their effect on susceptibility to sarcoidosis in the Slovenian population". International Journal of Molecular Medicine 20, no. 3 (2007): 385-390. https://doi.org/10.3892/ijmm.20.3.385
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