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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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October 2007 Volume 20 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

In vitro evidence of the role of hemoglobin during vasospasm on the modifications of the expression of PKCα and ζ

  • Authors:
    • Florence Lefranc
    • Boris Lubicz
    • Olivier Dewitte

  • View Affiliations / Copyright

    Affiliations: Laboratory of Toxicology, Institute of Pharmacology, Université Libre de Bruxelles, 1050 Brussels, Belgium. fllefran@ulb.ac.be
  • Pages: 415-419
    |
    Published online on: October 1, 2007
       https://doi.org/10.3892/ijmm.20.4.415
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Abstract

The cellular events leading to cerebral vasospasm after subarachnoid hemorrhage (SAH) are poorly understood, although the family of protein kinase C (PKC) is already known to play crucial roles in this pathology. Hemoglobin (Hb) is one of the major causes of the cerebral vasospasm that follows SAH. In the present study we investigated whether Hb can in vitro regulate PKC expression in endothelial as opposed to smooth-muscle cells. The levels of expression of PKCα and PKCζ were quantitatively determined by means of computer-assisted fluorescence microscopy in the A7r5 smooth-muscle rat cells and human umbilical endothelial cells (HUVECs). Hb significantly modified both calcium-dependent PKCα and calcium-independent PKCζ expression in HUVECs and A7r5 smooth-muscle rat cells. Our data showed that, in vitro, Hb promptly and markedly modified the levels of expression of both calcium-dependent PKCα and calcium-independent PKCζ. We are currently investigating the effects of specific PKC antagonists associated or not with calcium channel blockers on the expression of PKC and the in vivo severity of SAH-induced vasospasm. Our results encourage the prophylactic use of specific PKC isoform antagonists associated with calcium channel blockers early after SAH to prevent cerebral vasospasm.

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Copy and paste a formatted citation
Spandidos Publications style
Lefranc F, Lubicz B and Dewitte O: In vitro evidence of the role of hemoglobin during vasospasm on the modifications of the expression of PKCα and ζ. Int J Mol Med 20: 415-419, 2007.
APA
Lefranc, F., Lubicz, B., & Dewitte, O. (2007). In vitro evidence of the role of hemoglobin during vasospasm on the modifications of the expression of PKCα and ζ. International Journal of Molecular Medicine, 20, 415-419. https://doi.org/10.3892/ijmm.20.4.415
MLA
Lefranc, F., Lubicz, B., Dewitte, O."In vitro evidence of the role of hemoglobin during vasospasm on the modifications of the expression of PKCα and ζ". International Journal of Molecular Medicine 20.4 (2007): 415-419.
Chicago
Lefranc, F., Lubicz, B., Dewitte, O."In vitro evidence of the role of hemoglobin during vasospasm on the modifications of the expression of PKCα and ζ". International Journal of Molecular Medicine 20, no. 4 (2007): 415-419. https://doi.org/10.3892/ijmm.20.4.415
Copy and paste a formatted citation
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Spandidos Publications style
Lefranc F, Lubicz B and Dewitte O: In vitro evidence of the role of hemoglobin during vasospasm on the modifications of the expression of PKCα and ζ. Int J Mol Med 20: 415-419, 2007.
APA
Lefranc, F., Lubicz, B., & Dewitte, O. (2007). In vitro evidence of the role of hemoglobin during vasospasm on the modifications of the expression of PKCα and ζ. International Journal of Molecular Medicine, 20, 415-419. https://doi.org/10.3892/ijmm.20.4.415
MLA
Lefranc, F., Lubicz, B., Dewitte, O."In vitro evidence of the role of hemoglobin during vasospasm on the modifications of the expression of PKCα and ζ". International Journal of Molecular Medicine 20.4 (2007): 415-419.
Chicago
Lefranc, F., Lubicz, B., Dewitte, O."In vitro evidence of the role of hemoglobin during vasospasm on the modifications of the expression of PKCα and ζ". International Journal of Molecular Medicine 20, no. 4 (2007): 415-419. https://doi.org/10.3892/ijmm.20.4.415
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