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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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October 2007 Volume 20 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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October 2007 Volume 20 Issue 4

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Article

Procaspase-3 activation by a metalloprotease secreted from Vibrio vulnificus

  • Authors:
    • Hyo Young Kim
    • Alan K. Chang
    • Jung Eun Park
    • Il-Seon Park
    • Seong Myeong Yoon
    • Jung Sup Lee

  • View Affiliations / Copyright

    Affiliations: Research Center for Proteineous Materials, Chosun University, Gwangju 501-759, Korea
  • Pages: 591-595
    |
    Published online on: October 1, 2007
       https://doi.org/10.3892/ijmm.20.4.591
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Abstract

Vibrio vulnificus is a marine bacterium and a human pathogen capable of causing wound infection and septicemia. We previously showed that the metalloprotease vEP secreted by V. vulnificus activates prothrombin in vitro. To further investigate the ability of vEP to activate other zymogens, we used a mutant form of procaspase-3 which lacks the native cleavage sites as a zymogen. The mutant zymogen was activated by vEP to yield a mature enzyme with a maximum increase in caspase-3 activity of approximately 14-fold in a time-dependent manner. However, the increase started to decline with prolonged incubation and with higher protease concentration as a result of further cleavage of the mature enzyme. Western blot analysis revealed a band of ≈17 kDa for the cleavage product, which corresponded with the change in caspase-3 activity. The activated procaspase-3 by vEP was also able to cleave poly(ADP-ribose) polymerase in a cell-free system, and was inhibited by Ac-DEVD-CHO, a potent caspase-3 inhibitor. The results presented are the first to demonstrate the in vitro activation of one of the crucial enzymes involved in cell death by a bacterial extracellular metalloprotease.

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Copy and paste a formatted citation
Spandidos Publications style
Kim HY, Chang AK, Park JE, Park I, Yoon SM and Lee JS: Procaspase-3 activation by a metalloprotease secreted from Vibrio vulnificus. Int J Mol Med 20: 591-595, 2007.
APA
Kim, H.Y., Chang, A.K., Park, J.E., Park, I., Yoon, S.M., & Lee, J.S. (2007). Procaspase-3 activation by a metalloprotease secreted from Vibrio vulnificus. International Journal of Molecular Medicine, 20, 591-595. https://doi.org/10.3892/ijmm.20.4.591
MLA
Kim, H. Y., Chang, A. K., Park, J. E., Park, I., Yoon, S. M., Lee, J. S."Procaspase-3 activation by a metalloprotease secreted from Vibrio vulnificus". International Journal of Molecular Medicine 20.4 (2007): 591-595.
Chicago
Kim, H. Y., Chang, A. K., Park, J. E., Park, I., Yoon, S. M., Lee, J. S."Procaspase-3 activation by a metalloprotease secreted from Vibrio vulnificus". International Journal of Molecular Medicine 20, no. 4 (2007): 591-595. https://doi.org/10.3892/ijmm.20.4.591
Copy and paste a formatted citation
x
Spandidos Publications style
Kim HY, Chang AK, Park JE, Park I, Yoon SM and Lee JS: Procaspase-3 activation by a metalloprotease secreted from Vibrio vulnificus. Int J Mol Med 20: 591-595, 2007.
APA
Kim, H.Y., Chang, A.K., Park, J.E., Park, I., Yoon, S.M., & Lee, J.S. (2007). Procaspase-3 activation by a metalloprotease secreted from Vibrio vulnificus. International Journal of Molecular Medicine, 20, 591-595. https://doi.org/10.3892/ijmm.20.4.591
MLA
Kim, H. Y., Chang, A. K., Park, J. E., Park, I., Yoon, S. M., Lee, J. S."Procaspase-3 activation by a metalloprotease secreted from Vibrio vulnificus". International Journal of Molecular Medicine 20.4 (2007): 591-595.
Chicago
Kim, H. Y., Chang, A. K., Park, J. E., Park, I., Yoon, S. M., Lee, J. S."Procaspase-3 activation by a metalloprotease secreted from Vibrio vulnificus". International Journal of Molecular Medicine 20, no. 4 (2007): 591-595. https://doi.org/10.3892/ijmm.20.4.591
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